DET1_YEAST - dbPTM
DET1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DET1_YEAST
UniProt AC Q99288
Protein Name Broad-range acid phosphatase DET1
Gene Name DET1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 334
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Metal-independent, broad-range acid phosphatase. Involved, either directly or indirectly, in the bidirectional transport of sterols between the endoplasmic reticulum and the plasma membrane..
Protein Sequence MCEENVHVSEDVAGSHGSFTNARPRLIVLIRHGESESNKNKEVNGYIPNHLISLTKTGQIQARQAGIDLLRVLNVDDHNLVEDLAKKYIKDESSRRTLPLKDYTRLSREKDTNIVFYTSPYRRARETLKGILDVIDEYNELNSGVRICEDMRYDPHGKQKHAFWPRGLNNTGGVYENNEDNICEGKPGKCYLQYRVKDEPRIREQDFGNFQKINSMQDVMKKRSTYGHFFFRFPHGESAADVYDRVASFQETLFRHFHDRQERRPRDVVVLVTHGIYSRVFLMKWFRWTYEEFESFTNVPNGSVMVMELDESINRYVLRTVLPKWTDCEGDLTT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
110AcetylationYTRLSREKDTNIVFY
HHHHCCCCCCCEEEE		69.6024489116
186UbiquitinationEDNICEGKPGKCYLQ
CCCCCCCCCCCEEEE		28.4423749301
212AcetylationQDFGNFQKINSMQDV
HHCCCHHHCCCHHHH		39.4524489116
215PhosphorylationGNFQKINSMQDVMKK
CCHHHCCCHHHHHHH		22.6927017623
221AcetylationNSMQDVMKKRSTYGH
CCHHHHHHHHCCCCE		44.9025381059
248PhosphorylationDVYDRVASFQETLFR
HHHHHHHHHHHHHHH		25.3028889911
284AcetylationYSRVFLMKWFRWTYE
HHHHHHHHHHHHCHH		45.3824489116
324UbiquitinationVLRTVLPKWTDCEGD
HHHHHCCCCCCCCCC		59.5723749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DET1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DET1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DET1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DET1_YEASTDET1physical
10688190
UBR2_YEASTUBR2physical
16554755
DET1_YEASTDET1physical
18719252
ERP1_YEASTERP1physical
22940862
ERP2_YEASTERP2physical
22940862
MRM2_YEASTMRM2genetic
27708008
ENV10_YEASTENV10genetic
27708008
SIW14_YEASTSIW14genetic
27708008
AIM4_YEASTAIM4genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
SGF29_YEASTSGF29genetic
27708008
MGR1_YEASTMGR1genetic
27708008
RL35A_YEASTRPL35Agenetic
27708008
RL35B_YEASTRPL35Agenetic
27708008
BRE4_YEASTBRE4genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
CDC73_YEASTCDC73genetic
27708008
PALI_YEASTRIM9genetic
27708008
GLRX3_HUMANGLRX3physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DET1_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory