GUAA_YEAST - dbPTM
GUAA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GUAA_YEAST
UniProt AC P38625
Protein Name GMP synthase [glutamine-hydrolyzing]
Gene Name GUA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 525
Subcellular Localization Cytoplasm.
Protein Description
Protein Sequence MAAGEQVSNMFDTILVLDFGSQYSHLITRRLREFNIYAEMLPCTQKISELGWTPKGVILSGGPYSVYAEDAPHVDHAIFDLNVPILGICYGMQELAWINGKQVGRGDKREYGPATLKVIDDSNSLFKGMNDSTVWMSHGDKLHGLPTGYKTIATSDNSPYCGIVHETKPIYGIQFHPEVTHSTQGKTLLKNFAVDLCHAKQNWTMENFIDTEINRIRKLVGPTAEVIGAVSGGVDSTVASKLMTEAIGDRFHAILVDNGVLRLNEAANVKKTLVEGLGINLMVVDASEEFLSKLKGVTDPEKKRKIIGNTFIHVFEREAEKIKPKDGKEIQFLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLENMKLKLIEPLRELFKDEVRHLGELLGIPHDLVWRHPFPGPGIAIRVLGEVTKEQVEIARKADNIYIEEIKKAGLYNQISQAFACLLPVKSVGVMGDQRTYDQVIALRAIETTDFMTADWFPFEHSFLKKVASRIVNEVDGVARVTYDITSKPPATVEWE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
117AcetylationEYGPATLKVIDDSNS
CCCCCEEEEEECCCC		32.5624489116
122PhosphorylationTLKVIDDSNSLFKGM
EEEEEECCCCCCCCC		25.2728152593
124PhosphorylationKVIDDSNSLFKGMND
EEEECCCCCCCCCCC		38.8522369663
132PhosphorylationLFKGMNDSTVWMSHG
CCCCCCCCEEEECCC		21.6125521595
133PhosphorylationFKGMNDSTVWMSHGD
CCCCCCCEEEECCCC		22.5025521595
141AcetylationVWMSHGDKLHGLPTG
EEECCCCEECCCCCC		47.1524489116
147PhosphorylationDKLHGLPTGYKTIAT
CEECCCCCCCCEEEC		59.1821440633
155PhosphorylationGYKTIATSDNSPYCG
CCCEEECCCCCCCCC		26.2721440633
160PhosphorylationATSDNSPYCGIVHET
ECCCCCCCCCEEECC		11.7921440633
168AcetylationCGIVHETKPIYGIQF
CCEEECCCCEEEEEC		26.8324489116
190AcetylationTQGKTLLKNFAVDLC
CCCCHHHHHHHHHHH		53.8024489116
200AcetylationAVDLCHAKQNWTMEN
HHHHHCCCCCCCHHH		22.0925381059
223PhosphorylationIRKLVGPTAEVIGAV
HHHHHCCHHHHHHHH		29.5322369663
231PhosphorylationAEVIGAVSGGVDSTV
HHHHHHHCCCCCHHH		29.3322369663
236PhosphorylationAVSGGVDSTVASKLM
HHCCCCCHHHHHHHH		23.5222369663
237PhosphorylationVSGGVDSTVASKLMT
HCCCCCHHHHHHHHH		18.6722369663
240PhosphorylationGVDSTVASKLMTEAI
CCCHHHHHHHHHHHH		23.2222369663
241UbiquitinationVDSTVASKLMTEAIG
CCHHHHHHHHHHHHH		32.3224961812
270SuccinylationLNEAANVKKTLVEGL
HHHHHCHHHHHHHCC		39.5923954790
272PhosphorylationEAANVKKTLVEGLGI
HHHCHHHHHHHCCCC		30.2527017623
292PhosphorylationDASEEFLSKLKGVTD
CCCHHHHHHCCCCCC		41.0627017623
302AcetylationKGVTDPEKKRKIIGN
CCCCCHHHHHHEECC		64.3724489116
352PhosphorylationSISFKGPSQTIKTHH
HCEEECCCCCCCCCC		48.9330377154
371AcetylationLLENMKLKLIEPLRE
HHHHHHHHHHHHHHH		41.7324489116
381AcetylationEPLRELFKDEVRHLG
HHHHHHHHHHHHHHH		66.6524489116
418AcetylationRVLGEVTKEQVEIAR
EEEEECCHHHHHHHH		51.8524489116
426UbiquitinationEQVEIARKADNIYIE
HHHHHHHHCCCEEHH		51.5822106047
436AcetylationNIYIEEIKKAGLYNQ
CEEHHHHHHCCCHHH		39.5924489116
436SuccinylationNIYIEEIKKAGLYNQ
CEEHHHHHHCCCHHH		39.5923954790
441PhosphorylationEIKKAGLYNQISQAF
HHHHCCCHHHHHHHH		12.2422369663
445PhosphorylationAGLYNQISQAFACLL
CCCHHHHHHHHHHHC		12.9922369663
456PhosphorylationACLLPVKSVGVMGDQ
HHHCCCCEEEEECCC		25.0822369663
498PhosphorylationSFLKKVASRIVNEVD
HHHHHHHHHHHHHCC		26.0621440633
517UbiquitinationVTYDITSKPPATVEW
EEEECCCCCCCEEEC		46.5023749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GUAA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GUAA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GUAA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GUAA_YEAST !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GUAA_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124, AND MASSSPECTROMETRY.

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