dbPTM

IRC3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IRC3_YEAST
UniProt AC	Q06683
Protein Name	Putative ATP-dependent helicase IRC3
Gene Name	IRC3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	689
Subcellular Localization	Mitochondrion .
Protein Description
Protein Sequence	MTSTLATRLSTYSISLILQRIKIIKRCYSAPVLRDYQQDAIDACVNSIRQGTKRIGVSLATGGGKTVIFSNLINQLRQNYFKERQGNFKSLILVHRRELALQATATLKKIFPDLKVHIEMGKYDCDIEDSDVIVASVQTLIRRLHKYDTNSVNLIIIDEAHHSVANSYRSILDHFKASTAETKIPVIGFSATFERADKRALSMVMDKIVYHRGILEMIDDKWLCEAKFTSVKIEADLSDVKSTADDFQLAPLSSLMNTKEINEVILKTYLHKKQEKSLKSTLLFGVDKAHVQSLHKLFKDNGINTDYVTSDTKQIERDNIIQKFKNGETEVLMNCGIFTEGTDMPNIDCILLCRPTKSRSLLIQMIGRGLRLHHSKDHCHIIDFIGASSVGVVSAPTLLGIRSDDIEFDDATVEDLKAIQGEIIAKQQKIDERLRALFQTDEAAMENVTERNSVADWIHSANSVDLTLCSFDSFRNFTQSNNSYPSGKEFDEASEAVKEMELLMNSQYPWVKFASNAWGLPLKGKNHLRIYKEKSEDKLSMVYHLKMYRQLPCFITNKYADYVPKSIIKDANLWNVMSKVEKIINTLNSDLEGQTMQYQAISSKYSKWRQTVPTSKQRDFVFRKLKKVYGESSKDFIRLSLDDVTTYVNTKMTKGDASNLIFASSLAPVYPLKSLLRILEYQKRRSFIK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
358	Phosphorylation	LLCRPTKSRSLLIQM EEECCCCCHHHHHHH	29.58	29734811
535	Phosphorylation	LRIYKEKSEDKLSMV EEEEECCCCCHHHHH	52.71	28889911
543	Phosphorylation	EDKLSMVYHLKMYRQ CCHHHHHHHHHHHHH	7.87	28889911
633	Phosphorylation	KKVYGESSKDFIRLS HHHHCCCCCCEEEEE	31.76	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IRC3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IRC3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IRC3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H4_YEAST	HHF1	genetic	14764870
RAD61_YEAST	RAD61	genetic	14764870
H2A1_YEAST	HTA1	genetic	14764870
BIM1_YEAST	BIM1	genetic	14764870
MAD1_YEAST	MAD1	genetic	14764870
BUB1_YEAST	BUB1	genetic	14764870
CTF8_YEAST	CTF8	genetic	14764870
MAD3_YEAST	MAD3	genetic	14764870
MAD2_YEAST	MAD2	genetic	14764870
PFD5_YEAST	GIM5	genetic	14764870
CIK1_YEAST	CIK1	genetic	14764870
PFD4_YEAST	GIM3	genetic	14764870
CHL1_YEAST	CHL1	genetic	14764870
CTF4_YEAST	CTF4	genetic	14764870
KAR3_YEAST	KAR3	genetic	14764870
GLRX7_YEAST	GRX7	genetic	20093466
MFG1_YEAST	MFG1	genetic	20093466
PEX19_YEAST	PEX19	genetic	20093466
MKC7_YEAST	MKC7	genetic	20093466
MSH4_YEAST	MSH4	genetic	20093466
MAL12_YEAST	MAL12	genetic	20093466
YJS1_YEAST	YJL181W	genetic	20093466
PIR5_YEAST	YJL160C	genetic	20093466
YJ24_YEAST	KCH1	genetic	20093466
SAC1_YEAST	SAC1	genetic	20093466
SRL3_YEAST	SRL3	genetic	20093466
ERG3_YEAST	ERG3	genetic	20093466
MDL1_YEAST	MDL1	genetic	20093466
PEX12_YEAST	PEX12	genetic	20093466
UBX1_YEAST	SHP1	genetic	14764870
PEX5_YEAST	PEX5	genetic	14764870
PEX10_YEAST	PEX10	genetic	14764870
HOP2_YEAST	HOP2	genetic	14764870
UBR1_YEAST	UBR1	genetic	14764870
INP52_YEAST	INP52	genetic	14764870
H2AZ_YEAST	HTZ1	genetic	14764870
BUB3_YEAST	BUB3	genetic	14764870
SPC25_YEAST	SPC25	physical	22875988
MED3_YEAST	PGD1	physical	22875988
HSK3_YEAST	HSK3	physical	22875988
DYHC_YEAST	DYN1	physical	22875988
MMR1_YEAST	MMR1	physical	22875988
NKP2_YEAST	NKP2	physical	22875988
VPS20_YEAST	VPS20	physical	22875988
RPOM_YEAST	RPO41	genetic	25389272
IMG2_YEAST	IMG2	genetic	27708008
YBB0_YEAST	YBL010C	genetic	27708008
GLRX7_YEAST	GRX7	genetic	27708008
RS6A_YEAST	RPS6B	genetic	27708008
RS6B_YEAST	RPS6B	genetic	27708008
AGP1_YEAST	AGP1	genetic	27708008
MSH4_YEAST	MSH4	genetic	27708008
THIK_YEAST	POT1	genetic	27708008
PIR5_YEAST	YJL160C	genetic	27708008
YJ24_YEAST	KCH1	genetic	27708008
SAC1_YEAST	SAC1	genetic	27708008
SRL3_YEAST	SRL3	genetic	27708008
ERG3_YEAST	ERG3	genetic	27708008
INO4_YEAST	INO4	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IRC3_YEAST

Related Literatures of Post-Translational Modification