| UniProt ID | PCC1_YEAST | |
|---|---|---|
| UniProt AC | Q3E833 | |
| Protein Name | EKC/KEOPS complex subunit PCC1 | |
| Gene Name | PCC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 88 | |
| Subcellular Localization | Nucleus . Chromosome, telomere . | |
| Protein Description | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. PCC1 functions as a dimerization module for the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.. | |
| Protein Sequence | MTSKREKSLDHTLELKIPFETERQATIATKVLSPDPILKPQDFQVDYSSEKNVMLVQFRSIDDRVLRVGVSSIIDSIKTIVEAMDVLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Acetylation | -MTSKREKSLDHTLE -CCCHHHHCCCCEEE | 61.42 | 24489116 | |
| 16 | Acetylation | LDHTLELKIPFETER CCCEEEEECCCCCHH | 38.67 | 24489116 | |
| 30 | Ubiquitination | RQATIATKVLSPDPI HHHEEEEEECCCCCC | 31.96 | 24961812 | |
| 33 | Phosphorylation | TIATKVLSPDPILKP EEEEEECCCCCCCCC | 30.19 | 27017623 | |
| 39 | Ubiquitination | LSPDPILKPQDFQVD CCCCCCCCCCCEECC | 41.16 | 23749301 | |
| 39 | Acetylation | LSPDPILKPQDFQVD CCCCCCCCCCCEECC | 41.16 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCC1_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PCC1_YEAST | PCC1 | physical | 18951093 | |
| KAE1_YEAST | KAE1 | physical | 18951093 | |
| IF5_YEAST | TIF5 | genetic | 21459853 | |
| KAE1_YEAST | KAE1 | genetic | 21459853 | |
| GON7_YEAST | GON7 | genetic | 21459853 | |
| KHSE_YEAST | THR1 | genetic | 21459853 | |
| THRC_YEAST | THR4 | genetic | 21459853 | |
| PUS1_YEAST | PUS1 | genetic | 21459853 | |
| DHAS_YEAST | HOM2 | genetic | 21459853 | |
| TRM1_YEAST | TRM1 | genetic | 21459853 | |
| GON7_YEAST | GON7 | physical | 25735745 | |
| PCC1_YEAST | PCC1 | physical | 25735745 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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