YDR09_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YDR09_YEAST
• UniProt AC: Q04585
• Protein Name: Uncharacterized sugar kinase YDR109C
• Gene Name: YDR109C
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 715
• Protein Sequence: MKSRKRQNNMQNETREPAVLSSQETSISRISPQDPEAKFYVGVDVGTGSARACVIDQSGNMLSLAEKPIKREQLISNFITQSSREIWNAVCYCVRTVVEESGVDPERVRGIGFDATCSLVVVSATNFEEIAVGPDFTNNDQNIILWMDHRAMKETEEINSSGDKCLKYVGGQMSVEMEIPKIKWLKNNLEAGIFQDCKFFDLPDYLTFKATGKENRSFCSAVCKQGFLPVGVEGSDIGWSKEFLNSIGLSELTKNDFERLGGSLREKKNFLTAGECISPLDKKAACQLGLTEHCVVSSGIIDAYAGWVGTVAAKPESAVKGLAETENYKKDFNGAIGRLAAVAGTSTCHILLSKNPIFVHGVWGPYRDVLARGFWAAEGGQSCTGVLLDHLITTHPAFTELSHMANLAGVSKFEYLNKILETLVEKRKVRSVISLAKHLFFYGDYHGNRSPIADPNMRACIIGQSMDNSIEDLAVMYLSACEFISQQTRQIIEVMLKSGHEINAIFMSGGQCRNSLLMRLLADCTGLPIVIPRYVDAAVVFGSALLGAAASEDFDYTREKRTLKGQKSSQTKTERFNDSYSSIQKLSMEDRNSTNGFVSPHNLQLSTPSAPAKINNYSLPICTQQPLDKTSEESSKDASLTVGQESLGEGRYNGTSFLWKVMQELTGNARIVNPNEKTHPDRILLDTKYQIFLDMIETQRKYRRMVDKVEGSFSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	REPAVLSSQETSISR CCCHHHCCCCCCCCC	28.07	28889911
31	Phosphorylation	ETSISRISPQDPEAK CCCCCCCCCCCCCCC	18.52	28889911
450	Phosphorylation	GDYHGNRSPIADPNM CCCCCCCCCCCCCCC	25.34	28889911
465	Phosphorylation	RACIIGQSMDNSIED CEEEECCCCCCCHHH	23.92	28889911
469	Phosphorylation	IGQSMDNSIEDLAVM ECCCCCCCHHHHHHH	24.08	28889911
525	Phosphorylation	MRLLADCTGLPIVIP HHHHHHHHCCCEEEC	42.15	17563356
573	Phosphorylation	QKSSQTKTERFNDSY CCCCCCCHHHCCCCH	35.46	22369663
579	Phosphorylation	KTERFNDSYSSIQKL CHHHCCCCHHHHHHH	28.19	22369663
580	Phosphorylation	TERFNDSYSSIQKLS HHHCCCCHHHHHHHC	14.86	22369663
581	Phosphorylation	ERFNDSYSSIQKLSM HHCCCCHHHHHHHCC	25.56	22369663
582	Phosphorylation	RFNDSYSSIQKLSME HCCCCHHHHHHHCCC	22.32	22369663
656	Phosphorylation	EGRYNGTSFLWKVMQ CCCCCHHHHHHHHHH	21.53	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YDR09_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YDR09_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YDR09_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SED5_YEAST	SED5	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
MCM1_YEAST	MCM1	genetic	27708008
CDC24_YEAST	CDC24	genetic	27708008
STU1_YEAST	STU1	genetic	27708008
PRP9_YEAST	PRP9	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
SMD1_YEAST	SMD1	genetic	27708008
MPPA_YEAST	MAS2	genetic	27708008
RPC6_YEAST	RPC34	genetic	27708008
ASA1_YEAST	ASA1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-579, AND MASSSPECTROMETRY.
PubMed: 18407956

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-525, AND MASSSPECTROMETRY.
PubMed: 17563356