ZF64A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZF64A_HUMAN
• UniProt AC: Q9NPA5
• Protein Name: Zinc finger protein 64 homolog, isoforms 1 and 2
• Gene Name: ZFP64
• Organism: Homo sapiens (Human).
• Sequence Length: 681
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MNASSEGESFAGSVQIPGGTTVLVELTPDIHICGICKQQFNNLDAFVAHKQSGCQLTGTSAAAPSTVQFVSEETVPATQTQTTTRTITSETQTITVSAPEFVFEHGYQTYLPTESNENQTATVISLPAKSRTKKPTTPPAQKRLNCCYPGCQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERPFKCQICPYASRNSSQLTVHLRSHTGDAPFQCWLCSAKFKISSDLKRHMRVHSGEKPFKCEFCNVRCTMKGNLKSHIRIKHSGNNFKCPHCDFLGDSKATLRKHSRVHQSEHPEKCSECSYSCSSKAALRIHERIHCTDRPFKCNYCSFDTKQPSNLSKHMKKFHGDMVKTEALERKDTGRQSSRQVAKLDAKKSFHCDICDASFMREDSLRSHKRQHSEYSESKNSDVTVLQFQIDPSKQPATPLTVGHLQVPLQPSQVPQFSEGRVKIIVGHQVPQANTIVQAAAAAVNIVPPALVAQNPEELPGNSRLQILRQVSLIAPPQSSRCPSEAGAMTQPAVLLTTHEQTDGATLHQTLIPTASGGPQEGSGNQTFITSSGITCTDFEGLNALIQEGTAEVTVVSDGGQNIAVATTAPPVFSSSSQQELPKQTYSIIQGAAHPALLCPADSIPD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
142	Acetylation	PTTPPAQKRLNCCYP CCCCHHHHHCCCCCC	62.04	24431651
232	Methylation	HSDERPFKCQICPYA CCCCCCEEEEECCCC	28.10	115978315
288	Sumoylation	HSGEKPFKCEFCNVR CCCCCCEECEECCCE	41.19	28112733
399	Sumoylation	KFHGDMVKTEALERK HHCCHHHHHHHHHCC	33.73	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZF64A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZF64A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZF64A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BEGIN_HUMAN	BEGAIN	physical	16189514
ERG28_HUMAN	C14orf1	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
TLE1_HUMAN	TLE1	physical	16169070
ZN513_HUMAN	ZNF513	physical	20211142
PRGC2_HUMAN	PPARGC1B	physical	20211142
ZBTB9_HUMAN	ZBTB9	physical	20211142
TOPK_HUMAN	PBK	physical	25416956
AEN_HUMAN	AEN	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
TRI41_HUMAN	TRIM41	physical	25416956
F124A_HUMAN	FAM124A	physical	25416956
AEN_HUMAN	AEN	physical	21516116
TRI41_HUMAN	TRIM41	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-473 AND SER-487, ANDMASS SPECTROMETRY.
PubMed: 17525332