ZN513_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN513_HUMAN
• UniProt AC: Q8N8E2
• Protein Name: Zinc finger protein 513
• Gene Name: ZNF513
• Organism: Homo sapiens (Human).
• Sequence Length: 541
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional regulator that plays a role in retinal development and maintenance..
• Protein Sequence: MPRRKQSHPQPVKCEGVKVDTEDSLDEGPGALVLESDLLLGQDLEFEEEEEEEEGDGNSDQLMGFERDSEGDSLGARPGLPYGLSDDESGGGRALSAESEVEEPARGPGEARGERPGPACQLCGGPTGEGPCCGAGGPGGGPLLPPRLLYSCRLCTFVSHYSSHLKRHMQTHSGEKPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHAGPPTPPCPTCGFRCCTPRPARPPSPTEQEGAVPRRPEDALLLPDLSLHVPPGGASFLPDCGQLRGEGEGLCGTGSEPLPELLFPWTCRGCGQELEEGEGSRLGAAMCGRCMRGEAGGGASGGPQGPSDKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAHLDNLKRHQRVHTGEKPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATCAYTTGHWDNYKRHQKVHGHGGAGGPGLSASEGWAPPHSPPSVLSSRGPPALGTAGSRAVHTDSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	QSHPQPVKCEGVKVD CCCCCCCCCCCEECC	33.00	-
18	Ubiquitination	PVKCEGVKVDTEDSL CCCCCCEECCCCCCC	45.29	-
37	Phosphorylation	GALVLESDLLLGQDL CEEEEEECEECCCCC	31.77	33259812
69	Phosphorylation	LMGFERDSEGDSLGA HCCEEECCCCCCCCC	50.10	29255136
73	Phosphorylation	ERDSEGDSLGARPGL EECCCCCCCCCCCCC	39.29	23927012
82	Phosphorylation	GARPGLPYGLSDDES CCCCCCCCCCCCCCC	35.42	29255136
85	Phosphorylation	PGLPYGLSDDESGGG CCCCCCCCCCCCCCC	38.36	23401153
89	Phosphorylation	YGLSDDESGGGRALS CCCCCCCCCCCCCCC	50.13	29255136
96	Phosphorylation	SGGGRALSAESEVEE CCCCCCCCCCCCCCC	29.07	23401153
99	Phosphorylation	GRALSAESEVEEPAR CCCCCCCCCCCCCCC	46.81	21815630
127	Phosphorylation	CQLCGGPTGEGPCCG CCCCCCCCCCCCCCC	51.65	-
199	Phosphorylation	NLTRHTRTHTGEKPY CCCCCCCCCCCCCCC	25.58	-
201	Phosphorylation	TRHTRTHTGEKPYRC CCCCCCCCCCCCCCC	46.56	24719451
204	Acetylation	TRTHTGEKPYRCPHC CCCCCCCCCCCCCCC	49.01	30593767
233	Phosphorylation	RTHAGPPTPPCPTCG CCCCCCCCCCCCCCC	42.89	28985074
245	Phosphorylation	TCGFRCCTPRPARPP CCCCEECCCCCCCCC	26.42	-
253	Phosphorylation	PRPARPPSPTEQEGA CCCCCCCCCCCCCCC	47.32	29255136
255	Phosphorylation	PARPPSPTEQEGAVP CCCCCCCCCCCCCCC	55.42	29255136
349	Phosphorylation	GEAGGGASGGPQGPS CCCCCCCCCCCCCCC	47.78	-
356	Phosphorylation	SGGPQGPSDKGFACS CCCCCCCCCCCCCCC	59.80	-
363	Phosphorylation	SDKGFACSLCPFATH CCCCCCCCCCCCHHC	29.58	28442448
369	Phosphorylation	CSLCPFATHYPNHLA CCCCCCHHCCHHHHH	23.48	28442448
371	Phosphorylation	LCPFATHYPNHLARH CCCCHHCCHHHHHHH	11.02	28442448
404	Methylation	SAHLDNLKRHQRVHT HHHHHHHHHHCCCCC	54.83	115978167
411	Phosphorylation	KRHQRVHTGEKPYKC HHHCCCCCCCCCCCC	44.15	29496963
414	Sumoylation	QRVHTGEKPYKCPLC CCCCCCCCCCCCCCC	55.80	-
414	Sumoylation	QRVHTGEKPYKCPLC CCCCCCCCCCCCCCC	55.80	-
414	Ubiquitination	QRVHTGEKPYKCPLC CCCCCCCCCCCCCCC	55.80	-
439	Phosphorylation	KRHGRIHSGDKPFRC HHHCCCCCCCCCEEC	46.44	28674419
456	Phosphorylation	CNYSCNQSMNLKRHM CCCCCCCCHHHHHHH	8.81	30576142
460	Phosphorylation	CNQSMNLKRHMLRHT CCCCHHHHHHHHHHC	34.94	32142685
467	Phosphorylation	KRHMLRHTGEKPFRC HHHHHHHCCCCCEEE	40.37	23532336
476	Phosphorylation	EKPFRCATCAYTTGH CCCEEEECCCEECCC	10.99	25907765
479	Phosphorylation	FRCATCAYTTGHWDN EEEECCCEECCCHHH	13.64	25907765
480	Phosphorylation	RCATCAYTTGHWDNY EEECCCEECCCHHHH	14.05	25907765
481	Phosphorylation	CATCAYTTGHWDNYK EECCCEECCCHHHHH	17.86	25907765
487	Phosphorylation	TTGHWDNYKRHQKVH ECCCHHHHHHHCCCC	13.61	25907765
505	Phosphorylation	GAGGPGLSASEGWAP CCCCCCCCHHCCCCC	35.35	28111955
507	Phosphorylation	GGPGLSASEGWAPPH CCCCCCHHCCCCCCC	33.01	28111955
515	Phosphorylation	EGWAPPHSPPSVLSS CCCCCCCCCCHHHHC	44.26	30108239
518	Phosphorylation	APPHSPPSVLSSRGP CCCCCCCHHHHCCCC	38.79	28111955
521	Phosphorylation	HSPPSVLSSRGPPAL CCCCHHHHCCCCCCC	18.81	30108239
522	Phosphorylation	SPPSVLSSRGPPALG CCCHHHHCCCCCCCC	36.78	30108239
530	Phosphorylation	RGPPALGTAGSRAVH CCCCCCCCCCCCCCC	28.79	28111955
533	Phosphorylation	PALGTAGSRAVHTDS CCCCCCCCCCCCCCC	18.01	28111955
538	Phosphorylation	AGSRAVHTDSS---- CCCCCCCCCCC----	30.86	28122231
540	Phosphorylation	SRAVHTDSS------ CCCCCCCCC------	38.82	28122231
541	Phosphorylation	RAVHTDSS------- CCCCCCCC-------	47.23	28122231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN513_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN513_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN513_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN513_HUMAN	ZNF513	physical	20211142
PRGC2_HUMAN	PPARGC1B	physical	20211142

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613617: Retinitis pigmentosa 58 (RP58)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.