CC106_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC106_HUMAN
• UniProt AC: Q9BWC9
• Protein Name: Coiled-coil domain-containing protein 106
• Gene Name: CCDC106
• Organism: Homo sapiens (Human).
• Sequence Length: 280
• Subcellular Localization: Nucleus . Colocalizes with p53/TP53.
• Protein Description: Promotes the degradation of p53/TP53 protein and inhibits its transactivity..
• Protein Sequence: MNDRSSRRRTMKDDETFEISIPFDEAPHLDPQIFYSLSPSRRNFEEPPEAASSALALMNSVKTQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISSARMEAEDHCRMKPGPRRMEGDSRGGAGGEASDPESAASSLSGASEEGSASERRRQKQKGGASRRRFGKPKARERQRVKDADGVLCRYKKILGTFQKLKSMSRAFEHHRVDRNTVALTTPIAELLIVAPEKLAEVGEFDPSKERLLEYSRRCFLALDDETLKKVQALKKSKLLLPITYRFKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MNDRSSRRRTMK ---CCCHHHCCCCCC	30.93	24260401
20	Phosphorylation	DDETFEISIPFDEAP CCCCEEEEEECCCCC	19.60	27732954
35	Phosphorylation	HLDPQIFYSLSPSRR CCCHHHHHHCCCCCC	15.44	26074081
36	Phosphorylation	LDPQIFYSLSPSRRN CCHHHHHHCCCCCCC	16.18	26074081
38	Phosphorylation	PQIFYSLSPSRRNFE HHHHHHCCCCCCCCC	18.19	25849741
40	Phosphorylation	IFYSLSPSRRNFEEP HHHHCCCCCCCCCCC	40.26	26074081
121	Phosphorylation	PRRMEGDSRGGAGGE CCCCCCCCCCCCCCC	43.62	22210691
130	Phosphorylation	GGAGGEASDPESAAS CCCCCCCCCHHHHHH	49.77	28348404
134	Phosphorylation	GEASDPESAASSLSG CCCCCHHHHHHHHCC	34.23	30108239
137	Phosphorylation	SDPESAASSLSGASE CCHHHHHHHHCCCCC	31.37	30108239
138	Phosphorylation	DPESAASSLSGASEE CHHHHHHHHCCCCCC	23.10	30108239
140	Phosphorylation	ESAASSLSGASEEGS HHHHHHHCCCCCCCC	33.97	30108239
147	Phosphorylation	SGASEEGSASERRRQ CCCCCCCCHHHHHHH	31.72	-
149	Phosphorylation	ASEEGSASERRRQKQ CCCCCCHHHHHHHHH	33.08	22210691
161	Phosphorylation	QKQKGGASRRRFGKP HHHHCCHHHHHCCCC	29.60	-
163	Methylation	QKGGASRRRFGKPKA HHCCHHHHHCCCCCH	35.47	-
192	Phosphorylation	RYKKILGTFQKLKSM HHHHHHHHHHHHHHH	21.32	24719451
195	Ubiquitination	KILGTFQKLKSMSRA HHHHHHHHHHHHHHH	54.41	-
198	Phosphorylation	GTFQKLKSMSRAFEH HHHHHHHHHHHHHHH	32.21	-
200	Phosphorylation	FQKLKSMSRAFEHHR HHHHHHHHHHHHHCC	27.78	24719451
212	Phosphorylation	HHRVDRNTVALTTPI HCCCCCCCCEECCCH	14.19	-
216	Phosphorylation	DRNTVALTTPIAELL CCCCCEECCCHHHHH	22.31	-
217	Phosphorylation	RNTVALTTPIAELLI CCCCEECCCHHHHHH	17.34	-
240	Ubiquitination	VGEFDPSKERLLEYS HCCCCCCHHHHHHHH	52.84	29967540
269	Ubiquitination	VQALKKSKLLLPITY HHHHHHHCCCCEEEE	52.62	-
269	Sumoylation	VQALKKSKLLLPITY HHHHHHHCCCCEEEE	52.62	-
269	Sumoylation	VQALKKSKLLLPITY HHHHHHHCCCCEEEE	52.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
130	S	Phosphorylation	Kinase	CK2B	P67870	PSP
147	S	Phosphorylation	Kinase	CK2B	P67870	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC106_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC106_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATF4_HUMAN	ATF4	physical	16169070
CSN6_HUMAN	COPS6	physical	16169070
KAT5_HUMAN	KAT5	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
UT14A_HUMAN	UTP14A	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
P53_HUMAN	TP53	physical	16169070
ERG28_HUMAN	C14orf1	physical	16169070
RBM48_HUMAN	RBM48	physical	16169070
DPYL1_HUMAN	CRMP1	physical	16169070
EF1G_HUMAN	EEF1G	physical	16169070
A4_HUMAN	APP	physical	21832049
FAM9B_HUMAN	FAM9B	physical	25416956
TE2IP_HUMAN	TERF2IP	physical	26186194
NFM_HUMAN	NEFM	physical	26186194
TERF2_HUMAN	TERF2	physical	26186194
KCC1A_HUMAN	CAMK1	physical	26186194
TERF2_HUMAN	TERF2	physical	28514442
TE2IP_HUMAN	TERF2IP	physical	28514442
KCC1A_HUMAN	CAMK1	physical	28514442
NFM_HUMAN	NEFM	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.