dbPTM

GKAP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GKAP1_HUMAN
UniProt AC	Q5VSY0
Protein Name	G kinase-anchoring protein 1
Gene Name	GKAP1
Organism	Homo sapiens (Human).
Sequence Length	366
Subcellular Localization	Golgi apparatus.
Protein Description
Protein Sequence	MASAVLSSVPTTASRFALLQVDSGSGSDSEPGKGKGRNTGKSQTLGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPVQKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKVMNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEELSSSQTLSHDGGFFNRLEDDVHKILIREKRREQLTEYNGTDNCTAHEHNQEVVLKDGRIERLKLELERKDAEIQKLKNVITQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALEQERSKVKVLQAELAKYQGGRKGKRNSESDQCR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASAVLSSVP -----CCCHHHHCCC	20.01	28674151
7	Phosphorylation	-MASAVLSSVPTTAS -CCCHHHHCCCCCHH	23.77	28674151
8	Phosphorylation	MASAVLSSVPTTASR CCCHHHHCCCCCHHH	28.14	28634298
11	Phosphorylation	AVLSSVPTTASRFAL HHHHCCCCCHHHEEE	32.60	28634298
12	Phosphorylation	VLSSVPTTASRFALL HHHCCCCCHHHEEEE	19.30	28634298
14	Phosphorylation	SSVPTTASRFALLQV HCCCCCHHHEEEEEE	26.32	28634298
23	Phosphorylation	FALLQVDSGSGSDSE EEEEEEECCCCCCCC	35.68	26503892
25	Phosphorylation	LLQVDSGSGSDSEPG EEEEECCCCCCCCCC	38.79	26503892
27	Phosphorylation	QVDSGSGSDSEPGKG EEECCCCCCCCCCCC	39.39	26503892
29	Phosphorylation	DSGSGSDSEPGKGKG ECCCCCCCCCCCCCC	47.60	30266825
39	Phosphorylation	GKGKGRNTGKSQTLG CCCCCCCCCCCCCCC	44.63	18077418
42	Phosphorylation	KGRNTGKSQTLGSKS CCCCCCCCCCCCCCC	29.73	18077418
44	Phosphorylation	RNTGKSQTLGSKSTT CCCCCCCCCCCCCCC	39.93	18077418
50	Phosphorylation	QTLGSKSTTNEKKRE CCCCCCCCCHHHHHH	37.06	18077418
58	Acetylation	TNEKKREKRRKKKEQ CHHHHHHHHHHHHHH	62.63	71227
62	Ubiquitination	KREKRRKKKEQQQSE HHHHHHHHHHHHHHH	60.78	24816145
79	Ubiquitination	ELRNLAFKKIPQKSS HHHHHHHHCCCCCCC	44.16	29967540
80	Ubiquitination	LRNLAFKKIPQKSSH HHHHHHHCCCCCCCC	53.84	-
104	Ubiquitination	PLSNPVQKDSREENW CCCCCCCCCCHHHHH	58.88	32015554
106	Phosphorylation	SNPVQKDSREENWQE CCCCCCCCHHHHHHH	48.94	10671526
141	Phosphorylation	LLLSKLEYEEHKKEY HHHHHHCHHHHHHHH	36.73	28796482
148	Phosphorylation	YEEHKKEYEDAENTS HHHHHHHHHHHCCCH	28.17	28796482
156	Phosphorylation	EDAENTSTQSKVMNK HHHCCCHHHHHHCCH	34.52	-
158	Phosphorylation	AENTSTQSKVMNKKD HCCCHHHHHHCCHHH	27.57	-
219	Ubiquitination	RLEDDVHKILIREKR HHHHHHHHHHHHHHH	38.77	29967540
220	Ubiquitination	LEDDVHKILIREKRR HHHHHHHHHHHHHHH	2.03	32015554
231	Ubiquitination	EKRREQLTEYNGTDN HHHHHHHHHCCCCCC	35.80	29967540
259	Ubiquitination	DGRIERLKLELERKD CCCCHHHHHHHHHCH	46.25	-
271	Ubiquitination	RKDAEIQKLKNVITQ HCHHHHHHHHHHHHH	68.07	32015554
282	Ubiquitination	VITQWEAKYKEVKAR HHHHHHHHHHHHHHH	45.39	29967540
295	Acetylation	ARNAQLLKMLQEGEM HHHHHHHHHHHCCCC	46.27	19814989
298	Ubiquitination	AQLLKMLQEGEMKDK HHHHHHHHCCCCCCH	53.82	33845483
303	Acetylation	MLQEGEMKDKAEILL HHHCCCCCCHHEEEE	52.34	8259533
309	Phosphorylation	MKDKAEILLQVDESQ CCCHHEEEEECCHHH	1.74	33259812
323	Phosphorylation	QSIKNELTIQVTSLH HHHCCCCHHHHHHHH	11.81	-
327	Phosphorylation	NELTIQVTSLHAALE CCCHHHHHHHHHHHH	14.81	-
328	Phosphorylation	ELTIQVTSLHAALEQ CCHHHHHHHHHHHHH	21.21	-
349	Ubiquitination	VLQAELAKYQGGRKG HHHHHHHHHCCCCCC	51.21	33845483
360	Phosphorylation	GRKGKRNSESDQCR- CCCCCCCCCCCCCC-	42.37	25849741

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
106	S	Phosphorylation	Kinase	PKG	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM3	O75382	PMID:20352094

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GKAP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GKAP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHI1_HUMAN	HSD11B1	physical	21988832
SOX18_HUMAN	SOX18	physical	21988832
GKAP1_HUMAN	GKAP1	physical	25416956
MESH1_HUMAN	HDDC3	physical	25416956
FTM_HUMAN	RPGRIP1L	physical	27173435
RP25L_HUMAN	RPP25L	physical	27173435
TEFM_HUMAN	TEFM	physical	27173435
ECT2_HUMAN	ECT2	physical	27173435
CLU_HUMAN	CLUH	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GKAP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-25 AND SER-27,AND MASS SPECTROMETRY.	18669648 [Abstract]