| UniProt ID | SOX18_HUMAN | |
|---|---|---|
| UniProt AC | P35713 | |
| Protein Name | Transcription factor SOX-18 | |
| Gene Name | SOX18 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 384 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site.. | |
| Protein Sequence | MQRSPPGYGAQDDPPARRDCAWAPGHGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPRSPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPPQPPPEPFPAASGSARAFRELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAPEDCALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPYPGPLSPPPEAPPLESAEPLGPAADLWADVDLTEFDQYLNCSRTRPDAPGLPYHVALAKLGPRAMSCPEESSLISALSDASSAVYYSACISG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MQRSPPGYGAQ ----CCCCCCCCCCC | 20.68 | 24501219 | |
| 8 | Phosphorylation | MQRSPPGYGAQDDPP CCCCCCCCCCCCCCC | 18.30 | 22817900 | |
| 50 | Phosphorylation | AAPAAPASPPSPQRS CCCCCCCCCCCCCCC | 35.96 | 29449344 | |
| 53 | Phosphorylation | AAPASPPSPQRSPPR CCCCCCCCCCCCCCC | 36.73 | 29449344 | |
| 57 | Phosphorylation | SPPSPQRSPPRSPEP CCCCCCCCCCCCCCC | 33.73 | 27251275 | |
| 61 | Phosphorylation | PQRSPPRSPEPGRYG CCCCCCCCCCCCCCC | 39.11 | 29449344 | |
| 67 | Phosphorylation | RSPEPGRYGLSPAGR CCCCCCCCCCCCCCC | 28.47 | 23186163 | |
| 70 | Phosphorylation | EPGRYGLSPAGRGER CCCCCCCCCCCCCCC | 14.35 | 23403867 | |
| 214 | Phosphorylation | FDGLGLPTPERSPLD CCCCCCCCCCCCCCC | 42.71 | 27251275 | |
| 218 | Phosphorylation | GLPTPERSPLDGLEP CCCCCCCCCCCCCCC | 28.31 | 27251275 | |
| 289 | Phosphorylation | LYYGTLGTPGPYPGP CCCCCCCCCCCCCCC | 28.34 | 26853621 | |
| 363 | Phosphorylation | AMSCPEESSLISALS HHCCCCHHHHHHHHH | 28.87 | 30576142 | |
| 373 | Phosphorylation | ISALSDASSAVYYSA HHHHHHHCHHHHHHH | 24.66 | 30576142 | |
| 374 | Phosphorylation | SALSDASSAVYYSAC HHHHHHCHHHHHHHH | 24.39 | 30576142 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SOX18_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SOX18_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SOX18_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MEF2C_HUMAN | MEF2C | physical | 11554755 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 607823 | Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS) | |||||
| 137940 | Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome (HLTRS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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