TEFM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEFM_HUMAN
• UniProt AC: Q96QE5
• Protein Name: Transcription elongation factor, mitochondrial
• Gene Name: TEFM
• Organism: Homo sapiens (Human).
• Sequence Length: 360
• Subcellular Localization: Mitochondrion matrix . Mitochondrion matrix, mitochondrion nucleoid .
• Protein Description: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery..
• Protein Sequence: MSGSVLFTAGERWRCFLTPSRSSLYWALHNFCCRKKSTTPKKITPNVTFCDENAKEPENALDKLFSSEQQASILHVLNTASTKELEAFRLLRGRRSINIVEHRENFGPFQNLESLMNVPLFKYKSTVQVCNSILCPKTGREKRKSPENRFLRKLLKPDIERERLKAVNSIISIVFGTRRIAWAHLDRKLTVLDWQQSDRWSLMRGIYSSSVYLEEISSIISKMPKADFYVLEKTGLSIQNSSLFPILLHFHIMEAMLYALLNKTFAQDGQHQVLSMNRNAVGKHFELMIGDSRTSGKELVKQFLFDSILKADPRVFFPSDKIVHYRQMFLSTELQRVEELYDSLLQAIAFYELAVFDSQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGSVLFTA ------CCCCEEEEC	39.51	24505115
7	Ubiquitination	-MSGSVLFTAGERWR -CCCCEEEECCCCEE	4.05	22817900
8	Phosphorylation	MSGSVLFTAGERWRC CCCCEEEECCCCEEE	29.59	24505115
9	Ubiquitination	SGSVLFTAGERWRCF CCCEEEECCCCEEEE	15.54	21890473
22	Ubiquitination	CFLTPSRSSLYWALH EEECCCHHHHHHHHH	29.09	21890473
27	Ubiquitination	SRSSLYWALHNFCCR CHHHHHHHHHHHHCC	5.84	22817900
122	Ubiquitination	LMNVPLFKYKSTVQV HHCCCCCCCCHHHHH	60.49	22817900
122	Methylation	LMNVPLFKYKSTVQV HHCCCCCCCCHHHHH	60.49	115980043
124 (in isoform 1)	Ubiquitination	-	40.00	21890473
124	Methylation	NVPLFKYKSTVQVCN CCCCCCCCHHHHHHH	40.00	44482985
124	Ubiquitination	NVPLFKYKSTVQVCN CCCCCCCCHHHHHHH	40.00	22817900
125	O-linked_Glycosylation	VPLFKYKSTVQVCNS CCCCCCCHHHHHHHH	30.62	30379171
137 (in isoform 1)	Ubiquitination	-	63.72	21890473
137	Ubiquitination	CNSILCPKTGREKRK HHHCCCCCCCCCCCC	63.72	22817900
142	Ubiquitination	CPKTGREKRKSPENR CCCCCCCCCCCHHHH	64.86	22817900
156	Malonylation	RFLRKLLKPDIERER HHHHHHHCCHHHHHH	51.59	26320211
156	Ubiquitination	RFLRKLLKPDIERER HHHHHHHCCHHHHHH	51.59	29967540
168	Ubiquitination	RERLKAVNSIISIVF HHHHHHHHHHHHHHH	32.14	21890473
195	Ubiquitination	KLTVLDWQQSDRWSL CEEEEEHHHHHHHHH	32.35	21890473
218	Phosphorylation	VYLEEISSIISKMPK HHHHHHHHHHHHCCC	29.60	24719451
233	Ubiquitination	ADFYVLEKTGLSIQN CCEEEEEHHCCCCCC	43.67	-
283 (in isoform 1)	Ubiquitination	-	38.22	21890473
283	Ubiquitination	MNRNAVGKHFELMIG ECCCCCCCCEEEEEC	38.22	21890473
292	Phosphorylation	FELMIGDSRTSGKEL EEEEECCCCCCCHHH	32.04	22210691
297	Ubiquitination	GDSRTSGKELVKQFL CCCCCCCHHHHHHHH	47.87	29967540
307	Phosphorylation	VKQFLFDSILKADPR HHHHHHHHHHCCCCC	23.61	22673903
310	Ubiquitination	FLFDSILKADPRVFF HHHHHHHCCCCCEEC	49.42	22817900
310 (in isoform 1)	Ubiquitination	-	49.42	21890473
321	Ubiquitination	RVFFPSDKIVHYRQM CEECCCHHHHHHHHH	51.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEFM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEFM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEFM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RP25L_HUMAN	RPP25L	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.