DHI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHI1_HUMAN
• UniProt AC: P28845
• Protein Name: Corticosteroid 11-beta-dehydrogenase isozyme 1
• Gene Name: HSD11B1
• Organism: Homo sapiens (Human).
• Sequence Length: 292
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
• Protein Description: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity)..
• Protein Sequence: MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	FMAYYYYSANEEFRP HHHHHHHCCCHHHCH	14.43	24719451
56	Methylation	EMAYHLAKMGAHVVV HHHHHHHHCCCEEEE	44.20	23644510
67	Phosphorylation	HVVVTARSKETLQKV EEEEEECCHHHHHHH	32.17	30576142
123	N-linked_Glycosylation	LILNHITNTSLNLFH HHHHCCCCCCCCCCC	27.37	19159218
162	N-linked_Glycosylation	LPMLKQSNGSIVVVS HHHHHHCCCCEEEEE	45.82	19159218
195	Phosphorylation	FALDGFFSSIRKEYS HHHHHHHHHHHHHHC	23.69	29978859
196	Phosphorylation	ALDGFFSSIRKEYSV HHHHHHHHHHHHHCC	22.66	29978859
207	N-linked_Glycosylation	EYSVSRVNVSITLCV HHCCCCCCEEEEEEH	22.25	UniProtKB CARBOHYD
280	Phosphorylation	RKILEFLYSTSYNMD HHHHHHHHHHCCCHH	18.41	23663014
281	Phosphorylation	KILEFLYSTSYNMDR HHHHHHHHHCCCHHH	17.02	23663014
282	Phosphorylation	ILEFLYSTSYNMDRF HHHHHHHHCCCHHHH	22.98	23663014
283	Phosphorylation	LEFLYSTSYNMDRFI HHHHHHHCCCHHHHC	14.47	23663014
284	Phosphorylation	EFLYSTSYNMDRFIN HHHHHHCCCHHHHCC	18.00	23663014

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHI1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAD1_HUMAN	DAD1	physical	26186194
TMX2_HUMAN	TMX2	physical	26186194
CGT_HUMAN	UGT8	physical	26186194
BI1_HUMAN	TMBIM6	physical	26186194
GLBL2_HUMAN	GLB1L2	physical	26186194
C42S2_HUMAN	CDC42SE2	physical	26186194
RAB18_HUMAN	RAB18	physical	26186194
NHLC3_HUMAN	NHLRC3	physical	26186194
TOR1A_HUMAN	TOR1A	physical	26186194
FA69A_HUMAN	FAM69A	physical	26186194
TMX4_HUMAN	TMX4	physical	26186194
MANEA_HUMAN	MANEA	physical	26186194
CGT_HUMAN	UGT8	physical	28514442
NPTX1_HUMAN	NPTX1	physical	28514442
TMX4_HUMAN	TMX4	physical	28514442
BI1_HUMAN	TMBIM6	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H01111: Cortisone reductase deficiency (CRD)
• OMIM Disease
• 604931: Cortisone reductase deficiency (CRD)
• Kegg Drug
• D00156: Glycyrrhetinic acid (JAN); Enoxolone (INN); Hidermart (TN)
• D01899: Carbenoxolone sodium (JAN/USAN)
• D07615: Carbenoxolone (INN)
• DrugBank
• DB00635: Prednisone

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-123 AND ASN-162, AND MASSSPECTROMETRY.
PubMed: 19159218