MANEA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MANEA_HUMAN
• UniProt AC: Q5SRI9
• Protein Name: Glycoprotein endo-alpha-1,2-mannosidase
• Gene Name: MANEA
• Organism: Homo sapiens (Human).
• Sequence Length: 462
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein .
• Protein Sequence: MAKFRRRTCIILALFILFIFSLMMGLKMLRPNTATFGAPFGLDLLPELHQRTIHLGKNFDFQKSDRINSETNTKNLKSVEITMKPSKASELNLDELPPLNNYLHVFYYSWYGNPQFDGKYIHWNHPVLEHWDPRIAKNYPQGRHNPPDDIGSSFYPELGSYSSRDPSVIETHMRQMRSASIGVLALSWYPPDVNDENGEPTDNLVPTILDKAHKYNLKVTFHIEPYSNRDDQNMYKNVKYIIDKYGNHPAFYRYKTKTGNALPMFYVYDSYITKPEKWANLLTTSGSRSIRNSPYDGLFIALLVEEKHKYDILQSGFDGIYTYFATNGFTYGSSHQNWASLKLFCDKYNLIFIPSVGPGYIDTSIRPWNTQNTRNRINGKYYEIGLSAALQTRPSLISITSFNEWHEGTQIEKAVPKRTSNTVYLDYRPHKPGLYLELTRKWSEKYSKERATYALDRQLPVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAKFRRRTCIILALF CHHHHHHHHHHHHHH	13.27	22210691
21	Phosphorylation	LFILFIFSLMMGLKM HHHHHHHHHHHCHHH	15.56	-
35	O-linked_Glycosylation	MLRPNTATFGAPFGL HHCCCCCCCCCCCCH	22.14	OGP
63	Ubiquitination	GKNFDFQKSDRINSE CCCCCCCHHHCCCCC	55.08	29967540
64	O-linked_Glycosylation	KNFDFQKSDRINSET CCCCCCHHHCCCCCC	22.72	OGP
73	O-linked_Glycosylation	RINSETNTKNLKSVE CCCCCCCCCCCEEEE	28.82	55834617
78	O-linked_Glycosylation	TNTKNLKSVEITMKP CCCCCCEEEEEEECC	28.31	55834165
82	O-linked_Glycosylation	NLKSVEITMKPSKAS CCEEEEEEECCCCCC	12.97	55834169
86	O-linked_Glycosylation	VEITMKPSKASELNL EEEEECCCCCCCCCH	35.02	55834175
163	O-linked_Glycosylation	PELGSYSSRDPSVIE HHHCCCCCCCHHHHH	32.25	OGP
321	Phosphorylation	QSGFDGIYTYFATNG HCCCCCEEEEEECCC	10.83	-
323	Phosphorylation	GFDGIYTYFATNGFT CCCCEEEEEECCCCC	3.69	-
331	Phosphorylation	FATNGFTYGSSHQNW EECCCCCCCCCCCCH	16.85	-
400	O-linked_Glycosylation	RPSLISITSFNEWHE CCCEEEEEECCCCCC	22.07	OGP
424	Phosphorylation	KRTSNTVYLDYRPHK CCCCCEEEEECCCCC	7.57	-
427	Phosphorylation	SNTVYLDYRPHKPGL CCEEEEECCCCCCCE	24.37	-
431	Ubiquitination	YLDYRPHKPGLYLEL EEECCCCCCCEEEEE	43.39	-
435	Phosphorylation	RPHKPGLYLELTRKW CCCCCCEEEEEEHHH	12.21	25690035
439	Phosphorylation	PGLYLELTRKWSEKY CCEEEEEEHHHHHHH	22.34	25690035
443	Phosphorylation	LELTRKWSEKYSKER EEEEHHHHHHHCHHH	27.52	28555341
445	Ubiquitination	LTRKWSEKYSKERAT EEHHHHHHHCHHHHH	49.67	24816145
446	Phosphorylation	TRKWSEKYSKERATY EHHHHHHHCHHHHHH	22.41	-
447	Phosphorylation	RKWSEKYSKERATYA HHHHHHHCHHHHHHH	38.82	-
452	Phosphorylation	KYSKERATYALDRQL HHCHHHHHHHHHCCC	18.62	-
453	Phosphorylation	YSKERATYALDRQLP HCHHHHHHHHHCCCC	12.27	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MANEA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MANEA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MANEA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AMPH_HUMAN	AMPH	physical	16733250

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.