TMX4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMX4_HUMAN
• UniProt AC: Q9H1E5
• Protein Name: Thioredoxin-related transmembrane protein 4
• Gene Name: TMX4
• Organism: Homo sapiens (Human).
• Sequence Length: 349
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Sequence: MAGGRCGPQLTALLAAWIAAVAATAGPEEAALPPEQSRVQPMTASNWTLVMEGEWMLKFYAPWCPSCQQTDSEWEAFAKNGEILQISVGKVDVIQEPGLSGRFFVTTLPAFFHAKDGIFRRYRGPGIFEDLQNYILEKKWQSVEPLTGWKSPASLTMSGMAGLFSISGKIWHLHNYFTVTLGIPAWCSYVFFVIATLVFGLFMGLVLVVISECFYVPLPRHLSERSEQNRRSEEAHRAEQLQDAEEEKDDSNEEENKDSLVDDEEEKEDLGDEDEAEEEEEEDNLAAGVDEERSEANDQGPPGEDGVTREEVEPEEAEEGISEQPCPADTEVVEDSLRQRKSQHADKGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Ubiquitination	ILQISVGKVDVIQEP EEEEEEEEEEEEECC	32.86	-
115	Ubiquitination	LPAFFHAKDGIFRRY CCCHHCCCCCCCHHH	48.17	21963094
138	Ubiquitination	LQNYILEKKWQSVEP HHHHHHHHCCCCCCC	56.73	-
139	Ubiquitination	QNYILEKKWQSVEPL HHHHHHHCCCCCCCC	40.88	29967540
158	Phosphorylation	SPASLTMSGMAGLFS CCCEEECCHHCCCEE	21.85	28985074
251	Phosphorylation	AEEEKDDSNEEENKD HHHHCCCCCCCCCHH	57.16	29255136
259	Phosphorylation	NEEENKDSLVDDEEE CCCCCHHHCCCCHHH	31.72	28355574
294	Phosphorylation	AGVDEERSEANDQGP HCCCHHHHHHHCCCC	44.32	29255136
308	Phosphorylation	PPGEDGVTREEVEPE CCCCCCCCHHHCCHH	37.58	20639409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMX4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMX4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMX4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMX4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251 AND SER-259, ANDMASS SPECTROMETRY.
PubMed: 17081983