| UniProt ID | RMI1_MOUSE | |
|---|---|---|
| UniProt AC | Q9D4G9 | |
| Protein Name | RecQ-mediated genome instability protein 1 | |
| Gene Name | Rmi1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 616 | |
| Subcellular Localization | Nucleus. Forms foci in response to DNA damage.. | |
| Protein Description | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity).. | |
| Protein Sequence | MSVASAVLRVETWLLATWHVKVPPMWLEACVNWIQEENNNATLSQAQINKQVLEQWLLTDLRDLEHPLLPDDILELPKGELNGFYALQINSLVDVSQPAYSQIQKLRGKNTTNDLVSAETQSTPKPWEVRPSRMLMLQLTDGVTHIQGMEYQSIPALHSGLPPGTKILVRGCILFRLGVLLLKPENVKVLGGEVDGLSEENAQEKVLARLIGELDPTVPVIPNNSIHNVPKVSGGLDAVLGPSDEELLASLDESEESAANNDVAMERSCFSTGTSSNTTPTNPSGFEPGCNISSRPKEKPPNQPTHFTDGEFDDFSLEEALLLEETVQKEQMETKASQPLTLKENTGKCMEIFSHKPSSLNHTALIHKQGNSNFDEKTSEQMIHEDKFFDCASTRNHHKRFSAHDFTNDSKISEVDDAAQQTLSSSNVHCLRNKILNRKLDLSEKSSQISKENGHPFQACSSRSFENNTYLSIGMDLHSPPFIYLSVLMARKPKEVTTVTVKAFIVTLTGNLSSSGGFWGVTAKVSDGTAYLDVDFIDEILTSMIGYSVPEMKQLRKDPLKYKTFLEGLQKCQRDLIDLCCLMTISYDPSSCKGVVLELQDVGMEHVENLKKRLNK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MSVASAVL -------CCHHHHHH | 7.02 | - | |
| 111 | Phosphorylation | QKLRGKNTTNDLVSA HHHCCCCCCCCCCCC | 30.38 | 25293948 | |
| 112 | Phosphorylation | KLRGKNTTNDLVSAE HHCCCCCCCCCCCCC | 35.81 | 25293948 | |
| 117 | Phosphorylation | NTTNDLVSAETQSTP CCCCCCCCCCCCCCC | 27.90 | 25293948 | |
| 120 | Phosphorylation | NDLVSAETQSTPKPW CCCCCCCCCCCCCCC | 27.77 | 25293948 | |
| 122 | Phosphorylation | LVSAETQSTPKPWEV CCCCCCCCCCCCCCC | 54.84 | 25293948 | |
| 123 | Phosphorylation | VSAETQSTPKPWEVR CCCCCCCCCCCCCCC | 26.05 | 25293948 | |
| 225 | Phosphorylation | VPVIPNNSIHNVPKV CCCCCCCCCCCCCCC | 31.68 | 26745281 | |
| 293 | Phosphorylation | FEPGCNISSRPKEKP CCCCCCCCCCCCCCC | 13.30 | - | |
| 308 | Phosphorylation | PNQPTHFTDGEFDDF CCCCCCCCCCCCCCC | 35.17 | 23608596 | |
| 334 | Phosphorylation | VQKEQMETKASQPLT HHHHHHHHHCCCCEE | 26.94 | 24719451 | |
| 337 | Phosphorylation | EQMETKASQPLTLKE HHHHHHCCCCEEECC | 33.61 | 24719451 | |
| 341 | Phosphorylation | TKASQPLTLKENTGK HHCCCCEEECCCCCC | 42.33 | 24719451 | |
| 402 | Phosphorylation | RNHHKRFSAHDFTND CCCCCCCCHHHCCCC | 28.82 | 27600695 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RMI1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RMI1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RMI1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| IMB1_HUMAN | KPNB1 | physical | 20360068 | |
| RMI2_HUMAN | RMI2 | physical | 20360068 | |
| SSBP_HUMAN | SSBP1 | physical | 20360068 | |
| TOP3A_HUMAN | TOP3A | physical | 20360068 | |
| BLM_HUMAN | BLM | physical | 20360068 | |
| RFA2_HUMAN | RPA2 | physical | 20360068 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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