DDAH2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDAH2_HUMAN
• UniProt AC: O95865
• Protein Name: N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
• Gene Name: DDAH2
• Organism: Homo sapiens (Human).
• Sequence Length: 285
• Subcellular Localization: Cytoplasm . Mitochondrion . Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes.
• Protein Description: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation..
• Protein Sequence: MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGPSHLRGLCGMGGPRTVVAGSSDAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGLPGVPPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGTPGEGLGR -----CCCCCCCCCH	27.16	28857561
22	Phosphorylation	LIRGVPESLASGEGA HHHCCCHHHHCCCCC	24.14	19413330
51	Acetylation	EHGVLGGKLRQRLGL HHCCCCHHHHHHHCC	38.40	23749302
51	Ubiquitination	EHGVLGGKLRQRLGL HHCCCCHHHHHHHCC	38.40	-
105	Ubiquitination	PEVDGVRKALQDLGL CCCHHHHHHHHHHCC	51.55	-
127	Phosphorylation	ENATLDGTDVLFTGR CCCEECCEEEEEECC	23.70	-
132	Phosphorylation	DGTDVLFTGREFFVG CCEEEEEECCEEEEE	31.04	-
141	Phosphorylation	REFFVGLSKWTNHRG CEEEEEHHHHCCCCC	21.88	-
167	Phosphorylation	AVSTVPVSGPSHLRG EEEECCCCCCHHHHH	38.63	30177828
167	O-linked_Glycosylation	AVSTVPVSGPSHLRG EEEECCCCCCHHHHH	38.63	30379171
170	Phosphorylation	TVPVSGPSHLRGLCG ECCCCCCHHHHHCCC	38.38	30177828
178	Sulfoxidation	HLRGLCGMGGPRTVV HHHHCCCCCCCCEEE	5.68	30846556
183	Phosphorylation	CGMGGPRTVVAGSSD CCCCCCCEEEECCHH	23.59	20068231
188	Phosphorylation	PRTVVAGSSDAAQKA CCEEEECCHHHHHHH	18.46	21712546
194	Ubiquitination	GSSDAAQKAVRAMAV CCHHHHHHHHHHHHH	44.09	-
194	Acetylation	GSSDAAQKAVRAMAV CCHHHHHHHHHHHHH	44.09	25953088
207	Phosphorylation	AVLTDHPYASLTLPD HHHCCCCCCCCCCCC	12.85	-
245	Phosphorylation	GGGDLPNSQEALQKL CCCCCCCHHHHHHHH	27.71	30622161
253	Phosphorylation	QEALQKLSDVTLVPV HHHHHHHCCCEEEEC	36.75	29759185
256	Phosphorylation	LQKLSDVTLVPVSCS HHHHCCCEEEECCHH	27.33	27251275
261	O-linked_Glycosylation	DVTLVPVSCSELEKA CCEEEECCHHHHHHC	13.07	30379171
261	Phosphorylation	DVTLVPVSCSELEKA CCEEEECCHHHHHHC	13.07	25278378
263	Phosphorylation	TLVPVSCSELEKAGA EEEECCHHHHHHCCC	37.40	29759185
273	Phosphorylation	EKAGAGLSSLCLVLS HHCCCCHHHHHHHHC	21.98	24117733
274	Phosphorylation	KAGAGLSSLCLVLST HCCCCHHHHHHHHCC	28.30	24117733
280	Phosphorylation	SSLCLVLSTRPHS-- HHHHHHHCCCCCC--	18.19	24117733
281	Phosphorylation	SLCLVLSTRPHS--- HHHHHHCCCCCC---	44.02	24117733
285	Phosphorylation	VLSTRPHS------- HHCCCCCC-------	44.60	27966365

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDAH2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDAH2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDAH2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCH2_HUMAN	TRIP13	physical	19060904
VAC14_HUMAN	VAC14	physical	25416956
E41L2_HUMAN	EPB41L2	physical	26186194
E41L1_HUMAN	EPB41L1	physical	26186194
E41L3_HUMAN	EPB41L3	physical	26186194
DDAH1_HUMAN	DDAH1	physical	26186194
OGT1_HUMAN	OGT	physical	26186194
HCFC1_HUMAN	HCFC1	physical	26186194
ICLN_HUMAN	CLNS1A	physical	26186194
DDAH1_HUMAN	DDAH1	physical	28514442
E41L1_HUMAN	EPB41L1	physical	28514442
E41L2_HUMAN	EPB41L2	physical	28514442
ICLN_HUMAN	CLNS1A	physical	28514442
HCFC1_HUMAN	HCFC1	physical	28514442
OGT1_HUMAN	OGT	physical	28514442
E41L3_HUMAN	EPB41L3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00155: L-Citrulline