HMGX4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMGX4_HUMAN
• UniProt AC: Q9UGU5
• Protein Name: HMG domain-containing protein 4
• Gene Name: HMGXB4
• Organism: Homo sapiens (Human).
• Sequence Length: 601
• Subcellular Localization: Nucleus .
• Protein Description: Negatively regulates Wnt/beta-catenin signaling during development..
• Protein Sequence: MAYDDSVKKEDCFDGDHTFEDIGLAAGRSQREKKRSYKDFLREEEEIAAQVRNSSKKKLKDSELYFLGTDTHKKKRKHSSDDYYYGDISSLESSQKKKKKSSPQSTDTAMDLLKAITSPLAAGSKPSKKTGEKSSGSSSHSESKKEHHRKKVSGSSGELPLEDGGSHKSKKMKPLYVNTETLTLREPDGLKMKLILSPKEKGSSSVDEESFQYPSQQATVKKSSKKSARDEQGALLLGHELQSFLKTARKKHKSSSDAHSSPGPEGCGSDASQFAESHSANLDLSGLEPILVESDSSSGGELEAGELVIDDSYREIKKKKKSKKSKKKKDKEKHKEKRHSKSKRSLGLSAVPVGEVTVTSGPPPSIPYAGAAAPPLPLPGLHTDGHSEKKKKKEEKDKERERGEKPKKKNMSAYQVFCKEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKDKLIWKQKAQYLQHKQNKAEATTVKRKASSSEGSMKVKASSVGVLSPQKKSPPTTMLLPASPAKAPETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSIICALGPLACLTTQLPELNGCPKQVLSNTLDNIAYIMPGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Sumoylation	MAYDDSVKKEDCFDG CCCCCCCCHHHCCCC	55.16	28112733
54	Phosphorylation	IAAQVRNSSKKKLKD HHHHHHCCCCCCCCC	32.73	28555341
62	Phosphorylation	SKKKLKDSELYFLGT CCCCCCCCEEEEEEC	28.10	29449344
65	Phosphorylation	KLKDSELYFLGTDTH CCCCCEEEEEECCCC	7.84	29449344
69	Phosphorylation	SELYFLGTDTHKKKR CEEEEEECCCCCCCC	39.61	28555341
71	Phosphorylation	LYFLGTDTHKKKRKH EEEEECCCCCCCCCC	35.12	28555341
79	Phosphorylation	HKKKRKHSSDDYYYG CCCCCCCCCCCCCCC	38.20	23401153
80	Phosphorylation	KKKRKHSSDDYYYGD CCCCCCCCCCCCCCC	33.93	23927012
83	Phosphorylation	RKHSSDDYYYGDISS CCCCCCCCCCCCHHH	11.99	23927012
84	Phosphorylation	KHSSDDYYYGDISSL CCCCCCCCCCCHHHH	14.15	23927012
85	Phosphorylation	HSSDDYYYGDISSLE CCCCCCCCCCHHHHH	11.33	23927012
89	Phosphorylation	DYYYGDISSLESSQK CCCCCCHHHHHHHHH	33.34	20873877
90	Phosphorylation	YYYGDISSLESSQKK CCCCCHHHHHHHHHH	36.17	23312004
93	Phosphorylation	GDISSLESSQKKKKK CCHHHHHHHHHHHCC	43.28	26074081
94	Phosphorylation	DISSLESSQKKKKKS CHHHHHHHHHHHCCC	36.32	25159151
101	Phosphorylation	SQKKKKKSSPQSTDT HHHHHCCCCCCCHHH	57.01	23401153
102	Phosphorylation	QKKKKKSSPQSTDTA HHHHCCCCCCCHHHH	35.52	29255136
105	Phosphorylation	KKKSSPQSTDTAMDL HCCCCCCCHHHHHHH	31.47	29255136
106	Phosphorylation	KKSSPQSTDTAMDLL CCCCCCCHHHHHHHH	31.93	29255136
108	Phosphorylation	SSPQSTDTAMDLLKA CCCCCHHHHHHHHHH	24.78	23927012
117	Phosphorylation	MDLLKAITSPLAAGS HHHHHHHHCHHHCCC	29.20	22199227
118	Phosphorylation	DLLKAITSPLAAGSK HHHHHHHCHHHCCCC	16.29	23927012
124	Phosphorylation	TSPLAAGSKPSKKTG HCHHHCCCCCCCCCC	36.34	23927012
127	Phosphorylation	LAAGSKPSKKTGEKS HHCCCCCCCCCCCCC	50.99	25002506
135	Phosphorylation	KKTGEKSSGSSSHSE CCCCCCCCCCCCCCH	54.48	30206219
137	Phosphorylation	TGEKSSGSSSHSESK CCCCCCCCCCCCHHH	30.52	30206219
138	Phosphorylation	GEKSSGSSSHSESKK CCCCCCCCCCCHHHH	35.28	30206219
139	Phosphorylation	EKSSGSSSHSESKKE CCCCCCCCCCHHHHH	32.50	30206219
141	Phosphorylation	SSGSSSHSESKKEHH CCCCCCCCHHHHHHC	45.58	30206219
143	Phosphorylation	GSSSHSESKKEHHRK CCCCCCHHHHHHCCC	52.63	30206219
153	Phosphorylation	EHHRKKVSGSSGELP HHCCCCCCCCCCCCC	41.66	21815630
155	Phosphorylation	HRKKVSGSSGELPLE CCCCCCCCCCCCCCC	27.88	21815630
156	Phosphorylation	RKKVSGSSGELPLED CCCCCCCCCCCCCCC	39.55	21815630
166	Phosphorylation	LPLEDGGSHKSKKMK CCCCCCCCCCCCCCC	33.02	21815630
176	Phosphorylation	SKKMKPLYVNTETLT CCCCCCEEEECCEEE	10.53	22817900
181	Phosphorylation	PLYVNTETLTLREPD CEEEECCEEEEECCC	24.01	27135362
183	Phosphorylation	YVNTETLTLREPDGL EEECCEEEEECCCCC	31.05	27135362
191	Sumoylation	LREPDGLKMKLILSP EECCCCCEEEEEECC	39.25	28112733
197	Phosphorylation	LKMKLILSPKEKGSS CEEEEEECCCCCCCC	27.25	23401153
203	Phosphorylation	LSPKEKGSSSVDEES ECCCCCCCCCCCHHH	30.43	26657352
204	Phosphorylation	SPKEKGSSSVDEESF CCCCCCCCCCCHHHH	42.95	21815630
205	Phosphorylation	PKEKGSSSVDEESFQ CCCCCCCCCCHHHHC	34.97	28464451
210	Phosphorylation	SSSVDEESFQYPSQQ CCCCCHHHHCCCCHH	18.66	21815630
213	Phosphorylation	VDEESFQYPSQQATV CCHHHHCCCCHHHCC	11.66	23312004
215	Phosphorylation	EESFQYPSQQATVKK HHHHCCCCHHHCCCC	29.95	23312004
219	Phosphorylation	QYPSQQATVKKSSKK CCCCHHHCCCCCCCC	28.64	23312004
223	Phosphorylation	QQATVKKSSKKSARD HHHCCCCCCCCCCCH	41.49	-
243	Phosphorylation	LLGHELQSFLKTARK HHHHHHHHHHHHHHH	45.21	24719451
247	Phosphorylation	ELQSFLKTARKKHKS HHHHHHHHHHHHHCC	33.57	-
261	Phosphorylation	SSSDAHSSPGPEGCG CCCCCCCCCCCCCCC	24.82	24275569
322	Phosphorylation	EIKKKKKSKKSKKKK HHHHHHHCCCCHHHH	54.95	26657352
325	Phosphorylation	KKKKSKKSKKKKDKE HHHHCCCCHHHHHHH	54.14	26657352
345	Phosphorylation	RHSKSKRSLGLSAVP HHHHHHHHHCCCCEE	30.44	20068231
349	Phosphorylation	SKRSLGLSAVPVGEV HHHHHCCCCEEECEE	25.97	20068231
357	Phosphorylation	AVPVGEVTVTSGPPP CEEECEEEEECCCCC	17.48	20068231
359	Phosphorylation	PVGEVTVTSGPPPSI EECEEEEECCCCCCC	20.71	20068231
360	Phosphorylation	VGEVTVTSGPPPSIP ECEEEEECCCCCCCC	44.99	20068231
365	Phosphorylation	VTSGPPPSIPYAGAA EECCCCCCCCCCCCC	41.80	20068231
368	Phosphorylation	GPPPSIPYAGAAAPP CCCCCCCCCCCCCCC	18.92	20068231
383	Phosphorylation	LPLPGLHTDGHSEKK CCCCCCCCCCCCHHH	49.03	25627689
387	Phosphorylation	GLHTDGHSEKKKKKE CCCCCCCCHHHHHHH	57.55	20068231
459	Ubiquitination	DKLIWKQKAQYLQHK HHHHHHHHHHHHHHH	33.46	-
480	Phosphorylation	TTVKRKASSSEGSMK HCHHHHHCCCCCCCE	37.12	24719451
481	Phosphorylation	TVKRKASSSEGSMKV CHHHHHCCCCCCCEE	36.95	-
482	Phosphorylation	VKRKASSSEGSMKVK HHHHHCCCCCCCEEE	43.40	22210691
485	Phosphorylation	KASSSEGSMKVKASS HHCCCCCCCEEEEEE	16.04	-
491	Phosphorylation	GSMKVKASSVGVLSP CCCEEEEEEEEEECC	21.60	22167270
492	Phosphorylation	SMKVKASSVGVLSPQ CCEEEEEEEEEECCC	27.96	22167270
497	Phosphorylation	ASSVGVLSPQKKSPP EEEEEEECCCCCCCC	23.91	22167270
502	Phosphorylation	VLSPQKKSPPTTMLL EECCCCCCCCCEEEE	43.05	23927012
505	Phosphorylation	PQKKSPPTTMLLPAS CCCCCCCCEEEEECC	28.37	25159151
506	Phosphorylation	QKKSPPTTMLLPASP CCCCCCCEEEEECCC	16.17	23927012
512	Phosphorylation	TTMLLPASPAKAPET CEEEEECCCCCCCCC	24.37	23927012
519	Phosphorylation	SPAKAPETEPIDVAA CCCCCCCCCCCCHHH	46.10	28450419
534	Phosphorylation	HLQLLGESLSLIGHR HHHHHHHHHHHHHHH	22.81	24144214
536	Phosphorylation	QLLGESLSLIGHRLQ HHHHHHHHHHHHHHH	27.50	24144214

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMGX4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMGX4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
155	Phosphorylation	165 (10)	G ⇒ A;V	rs1053593	Waist-to-hip ratio adjusted for body mass index	25673412
156	Phosphorylation	165 (9)	G ⇒ A;V	rs1053593	Waist-to-hip ratio adjusted for body mass index	25673412
166	Phosphorylation	165 (1)	G ⇒ A;V	rs1053593	Waist-to-hip ratio adjusted for body mass index	25673412

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBBP4_HUMAN	RBBP4	physical	22939629
NCOR1_HUMAN	NCOR1	physical	22939629
SMCE1_HUMAN	SMARCE1	physical	22939629
JMJD6_HUMAN	JMJD6	physical	23455924
RAD51_HUMAN	RAD51	physical	26496610
RRAS_HUMAN	RRAS	physical	26496610
TBCA_HUMAN	TBCA	physical	26496610
RBG10_HUMAN	RABGAP1L	physical	26496610
RBG1L_HUMAN	RABGAP1L	physical	26496610
ARAP1_HUMAN	ARAP1	physical	26496610
DJC24_HUMAN	DNAJC24	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.