TBCA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBCA_HUMAN
• UniProt AC: O75347
• Protein Name: Tubulin-specific chaperone A
• Gene Name: TBCA
• Organism: Homo sapiens (Human).
• Sequence Length: 108
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Tubulin-folding protein; involved in the early step of the tubulin folding pathway..
• Protein Sequence: MADPRVRQIKIKTGVVKRLVKEKVMYEKEAKQQEEKIEKMRAEDGENYDIKKQAEILQESRMMIPDCQRRLEAAYLDLQRILENEKDLEEAEEYKEARLVLDSVKLEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Ubiquitination	DPRVRQIKIKTGVVK CCCHHHHHHCHHHHH	29.79	-
10	Ubiquitination	DPRVRQIKIKTGVVK CCCHHHHHHCHHHHH	29.79	-
12	Ubiquitination	RVRQIKIKTGVVKRL CHHHHHHCHHHHHHH	33.94	-
17	Ubiquitination	KIKTGVVKRLVKEKV HHCHHHHHHHHHHHH	37.29	-
23	2-Hydroxyisobutyrylation	VKRLVKEKVMYEKEA HHHHHHHHHHHHHHH	26.95	-
23	Acetylation	VKRLVKEKVMYEKEA HHHHHHHHHHHHHHH	26.95	23749302
23	Acetylation	VKRLVKEKVMYEKEA HHHHHHHHHHHHHHH	26.95	-
28	2-Hydroxyisobutyrylation	KEKVMYEKEAKQQEE HHHHHHHHHHHHHHH	45.55	-
28	Ubiquitination	KEKVMYEKEAKQQEE HHHHHHHHHHHHHHH	45.55	19608861
28	Ubiquitination	KEKVMYEKEAKQQEE HHHHHHHHHHHHHHH	45.55	-
28	Acetylation	KEKVMYEKEAKQQEE HHHHHHHHHHHHHHH	45.55	23749302
28	Acetylation	KEKVMYEKEAKQQEE HHHHHHHHHHHHHHH	45.55	-
31	Ubiquitination	VMYEKEAKQQEEKIE HHHHHHHHHHHHHHH	54.31	-
31	Ubiquitination	VMYEKEAKQQEEKIE HHHHHHHHHHHHHHH	54.31	-
36	Acetylation	EAKQQEEKIEKMRAE HHHHHHHHHHHHHHH	56.25	23749302
36	Acetylation	EAKQQEEKIEKMRAE HHHHHHHHHHHHHHH	56.25	-
39	Ubiquitination	QQEEKIEKMRAEDGE HHHHHHHHHHHHCCC	36.84	-
40	Sulfoxidation	QEEKIEKMRAEDGEN HHHHHHHHHHHCCCC	2.97	30846556
48	Phosphorylation	RAEDGENYDIKKQAE HHHCCCCCCHHHHHH	18.10	21945579
51	Ubiquitination	DGENYDIKKQAEILQ CCCCCCHHHHHHHHH	35.62	21890473
51	Acetylation	DGENYDIKKQAEILQ CCCCCCHHHHHHHHH	35.62	-
51	Acetylation	DGENYDIKKQAEILQ CCCCCCHHHHHHHHH	35.62	26822725
52	Ubiquitination	GENYDIKKQAEILQE CCCCCHHHHHHHHHH	55.89	21890473
52	2-Hydroxyisobutyrylation	GENYDIKKQAEILQE CCCCCHHHHHHHHHH	55.89	-
60	Phosphorylation	QAEILQESRMMIPDC HHHHHHHHHCCCHHH	16.71	20068231
61	Methylation	AEILQESRMMIPDCQ HHHHHHHHCCCHHHH	20.24	115918277
75	Phosphorylation	QRRLEAAYLDLQRIL HHHHHHHHHHHHHHH	14.06	28152594
86	Ubiquitination	QRILENEKDLEEAEE HHHHHCCCCHHHHHH	78.26	21906983
86	Acetylation	QRILENEKDLEEAEE HHHHHCCCCHHHHHH	78.26	23749302
94	Phosphorylation	DLEEAEEYKEARLVL CHHHHHHHHHHHHHH	12.97	28796482
94	Nitration	DLEEAEEYKEARLVL CHHHHHHHHHHHHHH	12.97	-
95	Ubiquitination	LEEAEEYKEARLVLD HHHHHHHHHHHHHHH	48.45	2190698
95	Acetylation	LEEAEEYKEARLVLD HHHHHHHHHHHHHHH	48.45	25953088
103	Phosphorylation	EARLVLDSVKLEA-- HHHHHHHHHHCCC--	19.59	21712546
105	Acetylation	RLVLDSVKLEA---- HHHHHHHHCCC----	44.56	25953088
105	Ubiquitination	RLVLDSVKLEA---- HHHHHHHHCCC----	44.56	21906983
105	2-Hydroxyisobutyrylation	RLVLDSVKLEA---- HHHHHHHHCCC----	44.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBCA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBCA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBCA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UPAR_HUMAN	PLAUR	physical	22939629
GDPP1_HUMAN	GDPGP1	physical	26344197
SC31A_HUMAN	SEC31A	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-28, AND MASS SPECTROMETRY.
PubMed: 19608861