dbPTM

UPAR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UPAR_HUMAN
UniProt AC	Q03405
Protein Name	Urokinase plasminogen activator surface receptor
Gene Name	PLAUR
Organism	Homo sapiens (Human).
Sequence Length	335
Subcellular Localization	Cell membrane . Cell projection, invadopodium membrane . Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. Isoform 1: Cell membrane Lipid-ancho
Protein Description	Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form..
Protein Sequence	MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	LRCMQCKTNGDCRVE CCCCCCCCCCCCCEE	52.65	-
74	N-linked_Glycosylation	CTHSEKTNRTLSYRT CCCCHHHCCEEEEHH	46.11	15861141
79	Nitration	KTNRTLSYRTGLKIT HHCCEEEEHHCCCCC	18.46	-
109	Nitration	NSGRAVTYSRSRYLE CCCCCEEEECCCEEE	8.76	-
114	Nitration	VTYSRSRYLECISCG EEEECCCEEEEEECC	14.22	-
171	Nitration	RHLRGCGYLPGCPGS CCCCCCCCCCCCCCC	17.50	-
184	N-linked_Glycosylation	GSNGFHNNDTFHFLK CCCCCCCCCCEEEEE	40.92	15861141
194	N-linked_Glycosylation	FHFLKCCNTTKCNEG EEEEEECCCCCCCCC	61.32	15861141
217	Phosphorylation	PQNGRQCYSCKGNST CCCCCCCEECCCCCC	14.57	-
217	Nitration	PQNGRQCYSCKGNST CCCCCCCEECCCCCC	14.57	-
222	N-linked_Glycosylation	QCYSCKGNSTHGCSS CCEECCCCCCCCCCC	29.27	22285761
254	Ubiquitination	ATGTHEPKNQSYMVR EECCCCCCCCCEEEE	65.71	-
255	N-linked_Glycosylation	TGTHEPKNQSYMVRG ECCCCCCCCCEEEEC	46.90	15861141
258	Nitration	HEPKNQSYMVRGCAT CCCCCCCEEEECCCC	7.00	-
305	GPI-anchor	LDVQYRSGAAPQPGP CCHHEECCCCCCCCC	19.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UPAR_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UPAR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UPAR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KNG1_HUMAN	KNG1	physical	14764580
EF1A1_HUMAN	EEF1A1	physical	16169070
PROF2_HUMAN	PFN2	physical	16169070
SEPR_HUMAN	FAP	physical	12376466
ITAM_HUMAN	ITGAM	physical	10744708
UROK_HUMAN	PLAU	physical	11501527
MPRI_HUMAN	IGF2R	physical	9566979
JAK1_HUMAN	JAK1	physical	9417082
TYK2_HUMAN	TYK2	physical	9417082
VMA21_HUMAN	VMA21	physical	22939629
VIGLN_HUMAN	HDLBP	physical	22939629
WDHD1_HUMAN	WDHD1	physical	22939629
ELAV1_HUMAN	ELAVL1	physical	14517288
UROK_HUMAN	PLAU	physical	19017363
TX101_HUMAN	TEX101	physical	19017363
TBB3_HUMAN	TUBB3	physical	26186194
LARG2_HUMAN	GYLTL1B	physical	26186194
LARG1_HUMAN	LARGE	physical	26186194
PKN1_HUMAN	PKN1	physical	26186194
PXDN_HUMAN	PXDN	physical	26186194
OZF_HUMAN	ZNF146	physical	26186194
MBTP1_HUMAN	MBTPS1	physical	26186194
DNA2_HUMAN	DNA2	physical	26186194
TAZ_HUMAN	TAZ	physical	26186194
LAMB2_HUMAN	LAMB2	physical	26186194
PGLT1_HUMAN	POGLUT1	physical	26186194
PMGT2_HUMAN	POMGNT2	physical	26186194
ARSA_HUMAN	ARSA	physical	26186194
GALNS_HUMAN	GALNS	physical	26186194
EXT1_HUMAN	EXT1	physical	26186194
CHSS1_HUMAN	CHSY1	physical	26186194
CHSS3_HUMAN	CHSY3	physical	26186194
DDX11_HUMAN	DDX11	physical	26186194
TBA1A_HUMAN	TUBA1A	physical	26186194
LOXL2_HUMAN	LOXL2	physical	26186194
ADCK1_HUMAN	ADCK1	physical	26186194
MA2A1_HUMAN	MAN2A1	physical	26186194
SPCS2_HUMAN	SPCS2	physical	26186194
EOGT_HUMAN	EOGT	physical	26186194
ANAG_HUMAN	NAGLU	physical	26186194
DNJB9_HUMAN	DNAJB9	physical	26186194
NDST2_HUMAN	NDST2	physical	26186194
NDST1_HUMAN	NDST1	physical	26186194
SPHM_HUMAN	SGSH	physical	26186194
ARSK_HUMAN	ARSK	physical	26186194
FUT11_HUMAN	FUT11	physical	26186194
SYDM_HUMAN	DARS2	physical	26186194
MA1A1_HUMAN	MAN1A1	physical	26186194
MGT4B_HUMAN	MGAT4B	physical	26186194
P4K2B_HUMAN	PI4K2B	physical	26186194
PCYOX_HUMAN	PCYOX1	physical	26186194
FAKD3_HUMAN	FASTKD3	physical	26186194
PCSK5_HUMAN	PCSK5	physical	26186194
CDYL_HUMAN	CDYL	physical	26186194
MGT5A_HUMAN	MGAT5	physical	26186194
P3H3_HUMAN	LEPREL2	physical	26186194
RUSD3_HUMAN	RPUSD3	physical	26186194
GSH0_HUMAN	GCLM	physical	26186194
GLT18_HUMAN	GALNT18	physical	26186194
ARSB_HUMAN	ARSB	physical	26186194
HUS1_HUMAN	HUS1	physical	26186194
MELK_HUMAN	MELK	physical	26186194
EMIL3_HUMAN	EMILIN3	physical	26186194
TATD2_HUMAN	TATDN2	physical	26186194
GT253_HUMAN	CERCAM	physical	26186194
DYR2_HUMAN	DHFRL1	physical	26186194
TRM11_HUMAN	TRMT11	physical	26186194
MRRP3_HUMAN	KIAA0391	physical	26186194
HXD13_HUMAN	HOXD13	physical	26186194
DHRS4_HUMAN	DHRS4	physical	26186194
MANEA_HUMAN	MANEA	physical	26186194
NOCT_HUMAN	CCRN4L	physical	26186194
PLTP_HUMAN	PLTP	physical	26186194
COT2_HUMAN	NR2F2	physical	26186194
SIA4C_HUMAN	ST3GAL4	physical	26186194
UBE3A_HUMAN	UBE3A	physical	26186194
PPOX_HUMAN	PPOX	physical	26186194
MA2A2_HUMAN	MAN2A2	physical	26186194
NEK4_HUMAN	NEK4	physical	26186194
EGFL7_HUMAN	EGFL7	physical	26186194
PCYXL_HUMAN	PCYOX1L	physical	26186194
XRCC3_HUMAN	XRCC3	physical	26186194
MCM9_HUMAN	MCM9	physical	26186194
LARG1_HUMAN	LARGE	physical	28514442
DDX11_HUMAN	DDX11	physical	28514442
PKN1_HUMAN	PKN1	physical	28514442
NDST1_HUMAN	NDST1	physical	28514442
MA2A2_HUMAN	MAN2A2	physical	28514442
FUT11_HUMAN	FUT11	physical	28514442
TATD2_HUMAN	TATDN2	physical	28514442
MA2A1_HUMAN	MAN2A1	physical	28514442
LARG2_HUMAN	GYLTL1B	physical	28514442
CHSS3_HUMAN	CHSY3	physical	28514442
TOP2B_HUMAN	TOP2B	physical	28514442
ARSB_HUMAN	ARSB	physical	28514442
EOGT_HUMAN	EOGT	physical	28514442
PXDN_HUMAN	PXDN	physical	28514442
NDST2_HUMAN	NDST2	physical	28514442
GALNS_HUMAN	GALNS	physical	28514442
ARSK_HUMAN	ARSK	physical	28514442
MA1A1_HUMAN	MAN1A1	physical	28514442
MCM9_HUMAN	MCM9	physical	28514442
TAZ_HUMAN	TAZ	physical	28514442
LOXL2_HUMAN	LOXL2	physical	28514442
PGLT1_HUMAN	POGLUT1	physical	28514442
MGT5A_HUMAN	MGAT5	physical	28514442
MGT4B_HUMAN	MGAT4B	physical	28514442
GSH0_HUMAN	GCLM	physical	28514442
XRCC3_HUMAN	XRCC3	physical	28514442
HUS1_HUMAN	HUS1	physical	28514442
PLTP_HUMAN	PLTP	physical	28514442
LAMB2_HUMAN	LAMB2	physical	28514442
PCSK5_HUMAN	PCSK5	physical	28514442
EXT1_HUMAN	EXT1	physical	28514442
DYR2_HUMAN	DHFRL1	physical	28514442
ANAG_HUMAN	NAGLU	physical	28514442
DHRS4_HUMAN	DHRS4	physical	28514442
SPHM_HUMAN	SGSH	physical	28514442
UBE3A_HUMAN	UBE3A	physical	28514442
NEK4_HUMAN	NEK4	physical	28514442
PCYOX_HUMAN	PCYOX1	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
DNJB9_HUMAN	DNAJB9	physical	28514442
ARSA_HUMAN	ARSA	physical	28514442
ADCK1_HUMAN	ADCK1	physical	28514442
RUSD3_HUMAN	RPUSD3	physical	28514442
P4K2B_HUMAN	PI4K2B	physical	28514442
P3H3_HUMAN	LEPREL2	physical	28514442
MELK_HUMAN	MELK	physical	28514442
SIA4C_HUMAN	ST3GAL4	physical	28514442
BGAL_HUMAN	GLB1	physical	28514442
PMGT2_HUMAN	POMGNT2	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
BMP8B_HUMAN	BMP8B	physical	28514442
MBTP1_HUMAN	MBTPS1	physical	28514442
TXD16_HUMAN	TXNDC16	physical	28514442
CHSS1_HUMAN	CHSY1	physical	28514442
EMIL3_HUMAN	EMILIN3	physical	28514442
NOCT_HUMAN	CCRN4L	physical	28514442
MANEA_HUMAN	MANEA	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UPAR_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Structure of human urokinase plasminogen activator in complex withits receptor."; Huai Q., Mazar A.P., Kuo A., Parry G.C., Shaw D.E., Callahan J.,Li Y., Yuan C., Bian C., Chen L., Furie B., Furie B.C., Cines D.B.,Huang M.; Science 311:656-659(2006). Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 23-297 IN COMPLEX WITH PLAU,GLYCOSYLATION AT ASN-74 AND ASN-194, AND DISULFIDE BONDS.	16456079 [Abstract]
"Crystal structure of the human urokinase plasminogen activatorreceptor bound to an antagonist peptide."; Llinas P., Le Du M.H., Gaardsvoll H., Danoe K., Ploug M., Gilquin B.,Stura E.A., Menez A.; EMBO J. 24:1655-1663(2005). Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 23-335 OF MUTANT GLN-222 INCOMPLEX WITH PEPTIDE ANTAGONIST, GLYCOSYLATION AT ASN-74; ASN-184;ASN-194 AND ASN-255, AND DISULFIDE BONDS.	15861141 [Abstract]