EGFL7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EGFL7_HUMAN
• UniProt AC: Q9UHF1
• Protein Name: Epidermal growth factor-like protein 7
• Gene Name: EGFL7
• Organism: Homo sapiens (Human).
• Sequence Length: 273
• Subcellular Localization: Secreted, extracellular space .
• Protein Description: Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis..
• Protein Sequence: MRGSQEVLLMWLLVLAVGGTEHAYRPGRRVCAVRAHGDPVSESFVQRVYQPFLTTCDGHRACSTYRTIYRTAYRRSPGLAPARPRYACCPGWKRTSGLPGACGAAICQPPCRNGGSCVQPGRCRCPAGWRGDTCQSDVDECSARRGGCPQRCVNTAGSYWCQCWEGHSLSADGTLCVPKGGPPRVAPNPTGVDSAMKEEVQRLQSRVDLLEEKLQLVLAPLHSLASQALEHGLPDPGSLLVHSFQQLGRIDSLSEQISFLEEQLGSCSCKKDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MRGSQEVLLMW ----CCCHHHHHHHH	16.89	24043423
20	Phosphorylation	LVLAVGGTEHAYRPG HHHHHCCCHHHCCCC	20.76	24043423
24	Phosphorylation	VGGTEHAYRPGRRVC HCCCHHHCCCCCCEE	21.17	24043423
49	Phosphorylation	ESFVQRVYQPFLTTC HHHHHHHHHCHHCCC	16.80	-
54	Phosphorylation	RVYQPFLTTCDGHRA HHHHCHHCCCCCCHH	26.25	-
54	O-linked_Glycosylation	RVYQPFLTTCDGHRA HHHHCHHCCCCCCHH	26.25	46203823
55	Phosphorylation	VYQPFLTTCDGHRAC HHHCHHCCCCCCHHH	15.67	-
55	O-linked_Glycosylation	VYQPFLTTCDGHRAC HHHCHHCCCCCCHHH	15.67	55831561
65	Phosphorylation	GHRACSTYRTIYRTA CCHHHHHHHHHHHHH	6.89	-
67	Phosphorylation	RACSTYRTIYRTAYR HHHHHHHHHHHHHHH	16.37	30576142
69	Phosphorylation	CSTYRTIYRTAYRRS HHHHHHHHHHHHHHC	10.99	30576142
71	Phosphorylation	TYRTIYRTAYRRSPG HHHHHHHHHHHHCCC	15.86	30576142
93	Ubiquitination	YACCPGWKRTSGLPG EEECCCCCCCCCCCC	52.27	21890473
190	O-linked_Glycosylation	PRVAPNPTGVDSAMK CCCCCCCCCHHHHHH	57.38	55834273
197	Ubiquitination	TGVDSAMKEEVQRLQ CCHHHHHHHHHHHHH	50.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EGFL7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EGFL7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EGFL7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMRD1_HUMAN	SMARCD1	physical	21988832
NOTC1_HUMAN	NOTCH1	physical	19503073
NOTC2_HUMAN	NOTCH2	physical	19503073
NOTC3_HUMAN	NOTCH3	physical	19503073
NOTC4_HUMAN	NOTCH4	physical	19503073

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.