NOTC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOTC4_HUMAN
• UniProt AC: Q99466
• Protein Name: Neurogenic locus notch homolog protein 4
• Gene Name: NOTCH4
• Organism: Homo sapiens (Human).
• Sequence Length: 2003
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.; Notch 4 intracellular domain: Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
• Protein Description: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity)..
• Protein Sequence: MQPPSLLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGPSLALLVVLSPPALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDPTYQERAAPQTQPLGKETDSLSAGFVVVMGVDLSRCGPDHPASRCPWDPGLLLRFLAAMAAVGALEPLLPGPLLAVHPHAGTAPPANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQSAPHRRRPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEGEEVGQAEETGPPSTCQLWSLSGGCGALPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSAVCCGEVQSGTFQGAWLGCPEPWEPLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGREAGPFPRARTVSVSVPPHGGGALPRCRTLSAGAGPRGGGACLQARTWSVDLAARGGGAYSHCRSLSGVGAGGGPTPRGRRFSAGMRGPRPNPAIMRGRYGVAAGRGGRVSTDDWPCDWVALGACGSASNIPIPPPCLTPSPERGSPQLDCGPPALQEMPINQGGEGKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	LLLLLCVSVVRPRGL HHHHHHHHHHCCCCC	17.56	24719451
93	O-linked_Glycosylation	APLGLPSSPSPLTPS CCCCCCCCCCCCCHH	27.70	OGP
95	O-linked_Glycosylation	LGLPSSPSPLTPSFL CCCCCCCCCCCHHHH	34.19	OGP
125	Phosphorylation	LEDPCPPSFCSKRGR CCCCCCHHHHCCCCC	24.83	23401153
128	Phosphorylation	PCPPSFCSKRGRCHI CCCHHHHCCCCCEEE	24.31	23401153
378	Phosphorylation	IDRVGSFSCLCPPGR CCCCCCEEEECCCCC	14.10	-
664	N-linked_Glycosylation	GCAPPEDNCTCHHGH CCCCCCCCCEECCCC	22.72	UniProtKB CARBOHYD
714	N-linked_Glycosylation	YPQPSGYNCTCPTGY CCCCCCCCCCCCCCC	20.39	UniProtKB CARBOHYD
964	N-linked_Glycosylation	APGYDGQNCSKELDA CCCCCCCCCCCCCHH	37.24	UniProtKB CARBOHYD
1105	Phosphorylation	HGGLCLPSPKPGFPP CCCEECCCCCCCCCC	32.38	24719451
1118	Phosphorylation	PPRCACLSGYGGPDC CCCCEECCCCCCCCC	29.83	-
1143	N-linked_Glycosylation	PPSPCLYNGSCSETT CCCCCCCCCCCCCCC	23.97	UniProtKB CARBOHYD
1320	Phosphorylation	FALARVLSLTLRVGL HHHHHHHHHHHHEEE	19.22	18691976
1322	Phosphorylation	LARVLSLTLRVGLWV HHHHHHHHHHEEEEE	14.78	23312004
1374	Phosphorylation	TQPLGKETDSLSAGF CCCCCCCCCCCCCCE	34.08	24114839
1376	Phosphorylation	PLGKETDSLSAGFVV CCCCCCCCCCCCEEE	31.48	24114839
1378	Phosphorylation	GKETDSLSAGFVVVM CCCCCCCCCCEEEEE	30.23	24114839
1493	Phosphorylation	GFTRRPRTQSAPHRR CCCCCCCCCCCCCCC	29.56	26074081
1495	Phosphorylation	TRRPRTQSAPHRRRP CCCCCCCCCCCCCCC	43.06	26074081
1508	Phosphorylation	RPPLGEDSIGLKALK CCCCCCCCCCCCCCC	17.79	29083192
1669	Phosphorylation	QPDRAGRTPLHAAVA CCCCCCCCCHHHHHH	29.32	18452278
1702	Phosphorylation	DARTEDGTTPLMLAA HCCCCCCCCHHHHHH	37.25	23879269
1703	Phosphorylation	ARTEDGTTPLMLAAR CCCCCCCCHHHHHHH	21.69	23879269
1899	Phosphorylation	GAYSHCRSLSGVGAG CHHHHCCCCCCCCCC	32.08	22985185
1910	Phosphorylation	VGAGGGPTPRGRRFS CCCCCCCCCCCCCCC	28.97	21130716

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOTC4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOTC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOTC4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELOC_HUMAN	TCEB1	physical	22001063
SMAD3_HUMAN	SMAD3	physical	16007227

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.