ARSB_HUMAN - dbPTM
ARSB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARSB_HUMAN
UniProt AC P15848
Protein Name Arylsulfatase B
Gene Name ARSB
Organism Homo sapiens (Human).
Sequence Length 533
Subcellular Localization Lysosome . Cell surface .
Protein Description Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. [PubMed: 19306108 Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium]
Protein Sequence MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMGPRGAASLPRGPGP
CCCCCCCCCCCCCCC		38.0724719451
87PhosphorylationVLLDNYYTQPLCTPS
EECCCCCCCCCCCCC		17.2226074081
913-oxoalanine (Cys)NYYTQPLCTPSRSQL
CCCCCCCCCCCHHHH		7.18-
91OxidationNYYTQPLCTPSRSQL
CCCCCCCCCCCHHHH		7.187628016
92PhosphorylationYYTQPLCTPSRSQLL
CCCCCCCCCCHHHHH		31.7926074081
94PhosphorylationTQPLCTPSRSQLLTG
CCCCCCCCHHHHHHC		26.8126074081
96PhosphorylationPLCTPSRSQLLTGRY
CCCCCCHHHHHHCCE		29.5326074081
100PhosphorylationPSRSQLLTGRYQIRT
CCHHHHHHCCEEECC		28.3626074081
103PhosphorylationSQLLTGRYQIRTGLQ
HHHHHCCEEECCCCC		15.0526074081
107PhosphorylationTGRYQIRTGLQHQII
HCCEEECCCCCCEEE		43.8226074081
164PhosphorylationPTRRGFDTYFGYLLG
CCCCCCHHHHHHHHC		20.63-
165PhosphorylationTRRGFDTYFGYLLGS
CCCCCHHHHHHHHCC		9.24-
168PhosphorylationGFDTYFGYLLGSEDY
CCHHHHHHHHCCCCC		6.7229759185
177PhosphorylationLGSEDYYSHERCTLI
HCCCCCCCCCHHHHH		16.79-
188N-linked_GlycosylationCTLIDALNVTRCALD
HHHHHHHCCEEEEEC		34.53UniProtKB CARBOHYD
188N-linked_GlycosylationCTLIDALNVTRCALD
HHHHHHHCCEEEEEC		34.5316399764
190PhosphorylationLIDALNVTRCALDFR
HHHHHCCEEEEECCC		20.96-
190O-linked_GlycosylationLIDALNVTRCALDFR
HHHHHCCEEEEECCC		20.9628657654
204PhosphorylationRDGEEVATGYKNMYS
CCCCEEHHCCCCCCC		46.3423401153
216PhosphorylationMYSTNIFTKRAIALI
CCCCCCCCHHHHHHH		18.8023401153
255PhosphorylationPEEYLKPYDFIQDKN
CHHHCCCCCHHCCCC		23.1525690035
279N-linked_GlycosylationLMDEAVGNVTAALKS
HHHHHHCHHHHHHHH		22.74UniProtKB CARBOHYD
291N-linked_GlycosylationLKSSGLWNNTVFIFS
HHHCCCCCCEEEEEE		39.06UniProtKB CARBOHYD
318MalonylationNWPLRGRKWSLWEGG
CCCCCCCCEECCCCC		43.9126320211
334PhosphorylationRGVGFVASPLLKQKG
CCCCHHHCHHHHHCC		15.6924719451
366N-linked_GlycosylationKLARGHTNGTKPLDG
HHHCCCCCCCCCCCC		50.9219159218
386PhosphorylationTISEGSPSPRIELLH
HHCCCCCCCCEEEEC		28.6217081983
417PhosphorylationMAPAKDDSSLPEYSA
CCCCCCCCCCCCHHH		43.86-
426N-linked_GlycosylationLPEYSAFNTSVHAAI
CCCHHHCCHHHHHHH		31.03UniProtKB CARBOHYD
458N-linked_GlycosylationFPPPSQYNVSEIPSS
CCCHHHCCCCCCCCC		24.17UniProtKB CARBOHYD
491PhosphorylationRHDLSREYPHIVTKL
HCCHHHHCHHHHHHH		10.05-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARSB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARSB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARSB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ARSB_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
253200Mucopolysaccharidosis 6 (MPS6)
272200Multiple sulfatase deficiency (MSD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARSB_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-366, AND MASSSPECTROMETRY.

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