ADCK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADCK1_HUMAN
• UniProt AC: Q86TW2
• Protein Name: Uncharacterized aarF domain-containing protein kinase 1
• Gene Name: ADCK1
• Organism: Homo sapiens (Human).
• Sequence Length: 530
• Subcellular Localization: Secreted .
• Protein Description: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr)..
• Protein Sequence: MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSVPYGSEEYLQLRSKSWPVFLQVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHSQAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHLLNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRTQISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	VPYGSEEYLQLRSKS CCCCCHHHHHHHCCC	8.83	110753941
72 (in isoform 2)	Phosphorylation	-	39.37	-
108	Ubiquitination	IKVGQHLGALDYLLP EEHHCCCCHHHHHCC	23.20	29967540
112	Phosphorylation	QHLGALDYLLPEEYT CCCCHHHHHCCHHHH	15.81	29759185
132	Phosphorylation	LHSQAPQSSMQEIRQ HHCCCCCCHHHHHHH	27.07	24114839
150	Ubiquitination	EDLGKEIHDLFQSFD HHHHHHHHHHHHCCC	27.15	29967540
176	Ubiquitination	VHKAVLHDGRTVAVK HHHHHCCCCCEEEEE	44.07	29967540
218	Ubiquitination	FPEFEFMWLVDEAKK CCCCCCCHHHHHHHH	9.88	29967540
263	Phosphorylation	PRIHWDLSTERVLLM CCEECCCCCCEEEEE	26.25	23532336
329	Phosphorylation	LVRKHPGTGKAEIVL EEEECCCCCCEEEEE	39.70	46159535
441	Phosphorylation	QMLLILKTNDLLRGI HHHHHHHHHHHHHHH	30.44	5053929
454	Phosphorylation	GIEAALGTRASASSF HHHHHHCCCCCHHHH	24.74	25247763
482	Phosphorylation	HKKKNTCSFFRRTQI HHCCCCCHHHHHCCC	25.94	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADCK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADCK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADCK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EXOC5_HUMAN	EXOC5	physical	21988832
ADCK1_HUMAN	ADCK1	physical	27499296
STML2_HUMAN	STOML2	physical	27499296
TOM5_HUMAN	TOMM5	physical	27499296
MIC19_HUMAN	CHCHD3	physical	27499296
MIC60_HUMAN	IMMT	physical	27499296
ATP5H_HUMAN	ATP5H	physical	27499296
DCMC_HUMAN	MLYCD	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
ATPO_HUMAN	ATP5O	physical	27499296
MTX1_HUMAN	MTX1	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
MTCH2_HUMAN	MTCH2	physical	27499296

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-441, AND MASSSPECTROMETRY.
PubMed: 18187866