TOM5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOM5_HUMAN
• UniProt AC: Q8N4H5
• Protein Name: Mitochondrial import receptor subunit TOM5 homolog
• Gene Name: TOMM5
• Organism: Homo sapiens (Human).
• Sequence Length: 51
• Subcellular Localization: Mitochondrion outer membrane ; Single-pass membrane protein .
• Protein Sequence: MFRIEGLAPKLDPEEMKRKMREDVISSIRNFLIYVALLRVTPFILKKLDSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MFRIEGLA -------CCCCCCCC	4.61	25944712
10	Ubiquitination	RIEGLAPKLDPEEMK CCCCCCCCCCHHHHH	60.97	23000965
10	Ubiquitination	RIEGLAPKLDPEEMK CCCCCCCCCCHHHHH	60.97	21890473
10	Acetylation	RIEGLAPKLDPEEMK CCCCCCCCCCHHHHH	60.97	26051181
10	Sumoylation	RIEGLAPKLDPEEMK CCCCCCCCCCHHHHH	60.97	28112733
17	Ubiquitination	KLDPEEMKRKMREDV CCCHHHHHHHHHHHH	52.74	33845483
17	2-Hydroxyisobutyrylation	KLDPEEMKRKMREDV CCCHHHHHHHHHHHH	52.74	-
17	Acetylation	KLDPEEMKRKMREDV CCCHHHHHHHHHHHH	52.74	26051181
26	Phosphorylation	KMREDVISSIRNFLI HHHHHHHHHHHHHHH	21.40	20068231
27	Phosphorylation	MREDVISSIRNFLIY HHHHHHHHHHHHHHH	17.91	20068231
46	Acetylation	RVTPFILKKLDSI-- HHHHHHHHHHHCC--	46.61	19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOM5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOM5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOM5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-46, AND MASS SPECTROMETRY.
PubMed: 19608861