GT253_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GT253_HUMAN
• UniProt AC: Q5T4B2
• Protein Name: Inactive glycosyltransferase 25 family member 3
• Gene Name: CERCAM
• Organism: Homo sapiens (Human).
• Sequence Length: 595
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro..
• Protein Sequence: MRAARAAPLLQLLLLLGPWLEAAGVAESPLPAVVLAILARNAEHSLPHYLGALERLDYPRARMALWCATDHNVDNTTEMLQEWLAAVGDDYAAVVWRPEGEPRFYPDEEGPKHWTKERHQFLMELKQEALTFARNWGADYILFADTDNILTNNQTLRLLMGQGLPVVAPMLDSQTYYSNFWCGITPQGYYRRTAEYFPTKNRQRRGCFRVPMVHSTFLASLRAEGADQLAFYPPHPNYTWPFDDIIVFAYACQAAGVSVHVCNEHRYGYMNVPVKSHQGLEDERVNFIHLILEALVDGPRMQASAHVTRPSKRPSKIGFDEVFVISLARRPDRRERMLASLWEMEISGRVVDAVDGWMLNSSAIRNLGVDLLPGYQDPYSGRTLTKGEVGCFLSHYSIWEEVVARGLARVLVFEDDVRFESNFRGRLERLMEDVEAEKLSWDLIYLGRKQVNPEKETAVEGLPGLVVAGYSYWTLAYALRLAGARKLLASQPLRRMLPVDEFLPIMFDQHPNEQYKAHFWPRDLVAFSAQPLLAAPTHYAGDAEWLSDTETSSPWDDDSGRLISWSGSQKTLRSPRLDLTGSSGHSLQPQPRDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Ubiquitination	ESPLPAVVLAILARN CCCHHHHHHHHHHHC	3.04	29967540
48	Ubiquitination	NAEHSLPHYLGALER CCHHCHHHHHHHHHH	35.42	21963094
49	Phosphorylation	AEHSLPHYLGALERL CHHCHHHHHHHHHHC	12.61	20363803
75	N-linked_Glycosylation	ATDHNVDNTTEMLQE HCCCCCCCHHHHHHH	44.62	UniProtKB CARBOHYD
112	Ubiquitination	YPDEEGPKHWTKERH CCCCCCCCCCCHHHH	63.73	29967540
122	Ubiquitination	TKERHQFLMELKQEA CHHHHHHHHHHHHHH	1.78	21963094
126	Ubiquitination	HQFLMELKQEALTFA HHHHHHHHHHHHHHH	32.55	21963094
153	N-linked_Glycosylation	TDNILTNNQTLRLLM CCCCCCCHHHHHHHH	30.86	UniProtKB CARBOHYD
200	Ubiquitination	TAEYFPTKNRQRRGC CHHHCCCCCCCCCCC	50.82	21963094
215	Phosphorylation	FRVPMVHSTFLASLR EECCCCHHHHHHHHH	14.94	26074081
216	Phosphorylation	RVPMVHSTFLASLRA ECCCCHHHHHHHHHH	14.06	26074081
220	Phosphorylation	VHSTFLASLRAEGAD CHHHHHHHHHHCCCC	22.12	24719451
237	N-linked_Glycosylation	AFYPPHPNYTWPFDD EECCCCCCCCCCHHH	43.78	UniProtKB CARBOHYD
275	Ubiquitination	GYMNVPVKSHQGLED CEECCCCCCCCCCCC	35.83	-
360	N-linked_Glycosylation	AVDGWMLNSSAIRNL CCCCEECCHHHHHHC	20.15	UniProtKB CARBOHYD
438	Ubiquitination	MEDVEAEKLSWDLIY HHHHHHHHHCCHHEE	55.67	-
492	Ubiquitination	RKLLASQPLRRMLPV HHHHHCCCHHHCCCH	25.91	21890473
492 (in isoform 2)	Ubiquitination	-	25.91	21890473
570	Ubiquitination	ISWSGSQKTLRSPRL EEECCCCCCCCCCCE	51.75	22817900
570 (in isoform 1)	Ubiquitination	-	51.75	21890473
574	Phosphorylation	GSQKTLRSPRLDLTG CCCCCCCCCCEECCC	19.93	17081983
582	Phosphorylation	PRLDLTGSSGHSLQP CCEECCCCCCCCCCC	28.10	-
583	Phosphorylation	RLDLTGSSGHSLQPQ CEECCCCCCCCCCCC	41.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GT253_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GT253_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GT253_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GOPC_HUMAN	GOPC	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.