NDST1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDST1_HUMAN
• UniProt AC: P52848
• Protein Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
• Gene Name: NDST1
• Organism: Homo sapiens (Human).
• Sequence Length: 882
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein .
• Protein Description: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. [PubMed: 10758005]
• Protein Sequence: MPALACLRRLCRHVSPQAVLFLLFIFCLFSVFISAYYLYGWKRGLEPSADAPEPDCGDPPPVAPSRLLPLKPVQAATPSRTDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIAPGKGDMPTLTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCVAYGVGIIGFFKANENSLLSAQLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLLAKTRSSESIPHLGADAGLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDIDDIFVGKEGTRMKVEDVKALFDTQNELRAHIPNFTFNLGYSGKFFHTGTNAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFHNQSVLAEQMALNKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWSIRVTSTEEYPHLKPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSSELDKIINGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFKHLVRFLHSWTNLRLQTLPPVQLAQKYFQIFSEEKDPLWQDPCEDKRHKDIWSKEKTCDRFPKLLIIGPQKTGTTALYLFLGMHPDLSSNYPSSETFEEIQFFNGHNYHKGIDWYMEFFPIPSNTTSDFYFEKSANYFDSEVAPRRAAALLPKAKVLTILINPADRAYSWYQHQRAHDDPVALKYTFHEVITAGSDASSKLRALQNRCLVPGWYATHIERWLSAYHANQILVLDGKLLRTEPAKVMDMVQKFLGVTNTIDYHKTLAFDPKKGFWCQLLEGGKTKCLGKSKGRKYPEMDLDSRAFLKDYYRDHNIELSKLLYKMGQTLPTWLREDLQNTR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
199	Phosphorylation	NLGLKDCSINPKSPL CCCCCCCCCCCCCCC	35.22	22798277
204	Phosphorylation	DCSINPKSPLLYVTR CCCCCCCCCCEEEEC	23.26	24719451
208	Phosphorylation	NPKSPLLYVTRPSEV CCCCCCEEEECHHHC	13.88	24719451
231	N-linked_Glycosylation	DWTVFQSNHSTYEPV CCEEEECCCCCCCCE	23.50	UniProtKB CARBOHYD
351	N-linked_Glycosylation	ELRAHIPNFTFNLGY HHHHHCCCEEEEECC	48.24	UniProtKB CARBOHYD
401	N-linked_Glycosylation	MQPHLFHNQSVLAEQ CCHHHHCCHHHHHHH	28.61	UniProtKB CARBOHYD
437	Phosphorylation	APHHSGVYPVHVQLY CCCCCCCCCEEHHHH	11.76	23663014
502	Phosphorylation	YNEYPGGSSELDKII CCCCCCCCCHHHHHH	26.93	-
503	Phosphorylation	NEYPGGSSELDKIIN CCCCCCCCHHHHHHC	45.51	-
552	Phosphorylation	HLVRFLHSWTNLRLQ HHHHHHHHHHCCCCC	37.43	-
658	Phosphorylation	YHKGIDWYMEFFPIP CCCCCCEEEEEECCC	5.30	29978859
666	Phosphorylation	MEFFPIPSNTTSDFY EEEECCCCCCCCCCE	47.75	29978859
667	N-linked_Glycosylation	EFFPIPSNTTSDFYF EEECCCCCCCCCCEE	41.86	UniProtKB CARBOHYD
668	Phosphorylation	FFPIPSNTTSDFYFE EECCCCCCCCCCEEE	31.82	29978859
669	Phosphorylation	FPIPSNTTSDFYFEK ECCCCCCCCCCEEEC	30.46	29978859
670	Phosphorylation	PIPSNTTSDFYFEKS CCCCCCCCCCEEECC	24.55	29978859
673	Phosphorylation	SNTTSDFYFEKSANY CCCCCCCEEECCCCC	18.80	29978859
711	Phosphorylation	INPADRAYSWYQHQR ECHHHHHHHHHHHHC	10.71	-
712	Phosphorylation	NPADRAYSWYQHQRA CHHHHHHHHHHHHCC	20.51	-
714	Phosphorylation	ADRAYSWYQHQRAHD HHHHHHHHHHHCCCC	7.09	-
801	Phosphorylation	KFLGVTNTIDYHKTL HHHCCCCCCCCCCCC	13.08	22210691
804	Phosphorylation	GVTNTIDYHKTLAFD CCCCCCCCCCCCCCC	11.02	22210691
837	Phosphorylation	GKSKGRKYPEMDLDS CCCCCCCCCCCCCCH	11.76	24719451
844	Phosphorylation	YPEMDLDSRAFLKDY CCCCCCCHHHHHHHH	32.57	24719451
851	Phosphorylation	SRAFLKDYYRDHNIE HHHHHHHHHHHCCHH	9.98	22817900
852	Phosphorylation	RAFLKDYYRDHNIEL HHHHHHHHHHCCHHH	21.50	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDST1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDST1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDST1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NDST1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616116: Mental retardation, autosomal recessive 46 (MRT46)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.