| UniProt ID | GALNS_HUMAN | |
|---|---|---|
| UniProt AC | P34059 | |
| Protein Name | N-acetylgalactosamine-6-sulfatase | |
| Gene Name | GALNS | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 522 | |
| Subcellular Localization | Lysosome. | |
| Protein Description | ||
| Protein Sequence | MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 79 | 3-oxoalanine (Cys) | FYSANPLCSPSRAAL CCCCCCCCCHHHHHH | 6.24 | - | |
| 79 | Oxidation | FYSANPLCSPSRAAL CCCCCCCCCHHHHHH | 6.24 | 22940367 | |
| 200 | Phosphorylation | EFPINLKTGEANLTQ CCCCCCCCCCCCHHH | 43.34 | 24043423 | |
| 204 | N-linked_Glycosylation | NLKTGEANLTQIYLQ CCCCCCCCHHHHHHH | 39.04 | 22940367 | |
| 204 | N-linked_Glycosylation | NLKTGEANLTQIYLQ CCCCCCCCHHHHHHH | 39.04 | 16399764 | |
| 206 | Phosphorylation | KTGEANLTQIYLQEA CCCCCCHHHHHHHHH | 16.84 | 24043423 | |
| 209 | Phosphorylation | EANLTQIYLQEALDF CCCHHHHHHHHHHHH | 7.78 | 24043423 | |
| 394 | Phosphorylation | GDTLMAATLGQHKAH CCEEEEEEECCCHHH | 23.14 | - | |
| 423 | N-linked_Glycosylation | IDFCPGQNVSGVTTH CCCCCCCCCCCCEEC | 35.52 | 22940367 | |
| 423 | N-linked_Glycosylation | IDFCPGQNVSGVTTH CCCCCCCCCCCCEEC | 35.52 | 22940367 | |
| 461 | Phosphorylation | LSFASAEYQEALSRI CCHHCHHHHHHHHHH | 16.03 | - | |
| 513 | Phosphorylation | KCLTPPESIPKKCLW CCCCCCHHCCCCCCC | 50.38 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GALNS_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GALNS_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GALNS_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ATX2L_HUMAN | ATXN2L | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 253000 | Mucopolysaccharidosis 4A (MPS4A) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| N-linked Glycosylation | |
| Reference | PubMed |
| "Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-423, AND MASSSPECTROMETRY. | |
