PGLT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGLT1_HUMAN
• UniProt AC: Q8NBL1
• Protein Name: Protein O-glucosyltransferase 1 {ECO:0000305}
• Gene Name: POGLUT1 {ECO:0000312|HGNC:HGNC:22954}
• Organism: Homo sapiens (Human).
• Sequence Length: 392
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. [PubMed: 21081508]
• Protein Sequence: MEWWASSPLRLWLLLFLLPSAQGRQKESGSKWKVFIDQINRSLENYEPCSSQNCSCYHGVIEEDLTPFRGGISRKMMAEVVRRKLGTHYQITKNRLYRENDCMFPSRCSGVEHFILEVIGRLPDMEMVINVRDYPQVPKWMEPAIPVFSFSKTSEYHDIMYPAWTFWEGGPAVWPIYPTGLGRWDLFREDLVRSAAQWPWKKKNSTAYFRGSRTSPERDPLILLSRKNPKLVDAEYTKNQAWKSMKDTLGKPAAKDVHLVDHCKYKYLFNFRGVAASFRFKHLFLCGSLVFHVGDEWLEFFYPQLKPWVHYIPVKTDLSNVQELLQFVKANDDVAQEIAERGSQFIRNHLQMDDITCYWENLLSEYSKFLSYNVTRRKGYDQIIPKMLKTEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEWWASSPLRLWL --CCHHHCCHHHHHH	20.83	20068231
7	Phosphorylation	-MEWWASSPLRLWLL -CCHHHCCHHHHHHH	21.87	20068231
20	Phosphorylation	LLLFLLPSAQGRQKE HHHHHCHHHCCCCCC	32.94	20068231
40	N-linked_Glycosylation	KVFIDQINRSLENYE CHHHHHHHHHHHCCC	23.12	28775322
53	N-linked_Glycosylation	YEPCSSQNCSCYHGV CCCCCCCCCEEECCC	22.93	28775322
84	Ubiquitination	MAEVVRRKLGTHYQI HHHHHHHHCCCCEEE	40.48	-
87	Phosphorylation	VVRRKLGTHYQITKN HHHHHCCCCEEECCC	28.04	21406692
89	Phosphorylation	RRKLGTHYQITKNRL HHHCCCCEEECCCCE	11.05	21406692
92	Phosphorylation	LGTHYQITKNRLYRE CCCCEEECCCCEECC	13.52	21406692
93	Ubiquitination	GTHYQITKNRLYREN CCCEEECCCCEECCC	41.52	-
109	Phosphorylation	CMFPSRCSGVEHFIL CCCCCCCCCHHHHHH	44.77	22210691
149	Phosphorylation	EPAIPVFSFSKTSEY CCCCCEEECCCCCCC	28.92	24719451
151	Phosphorylation	AIPVFSFSKTSEYHD CCCEEECCCCCCCCC	33.55	22210691
194	Phosphorylation	FREDLVRSAAQWPWK HHHHHHHHHHHCCCC	22.07	27251275
204	N-linked_Glycosylation	QWPWKKKNSTAYFRG HCCCCCCCCCCCCCC	54.17	28775322
204	N-linked_Glycosylation	QWPWKKKNSTAYFRG HCCCCCCCCCCCCCC	54.17	28775322
230	Ubiquitination	LLSRKNPKLVDAEYT EEECCCCCCCCCHHH	71.22	-
238	Ubiquitination	LVDAEYTKNQAWKSM CCCCHHHHHHHHHHH	46.27	-
277	Phosphorylation	NFRGVAASFRFKHLF CCCCHHHCCCHHHHH	13.76	23532336
372	Phosphorylation	EYSKFLSYNVTRRKG HHHHHHCCCCCCCCC	18.79	-
373	N-linked_Glycosylation	YSKFLSYNVTRRKGY HHHHHCCCCCCCCCC	25.88	28775322

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PGLT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PGLT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGLT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBR4_HUMAN	UBR4	physical	26186194
CALX_HUMAN	CANX	physical	26186194
ZZEF1_HUMAN	ZZEF1	physical	26186194
HECD3_HUMAN	HECTD3	physical	26186194
CGAT2_HUMAN	CSGALNACT2	physical	26186194
PON2_HUMAN	PON2	physical	26186194
KCMF1_HUMAN	KCMF1	physical	26186194
CGAT2_HUMAN	CSGALNACT2	physical	28514442
CALX_HUMAN	CANX	physical	28514442
LYAG_HUMAN	GAA	physical	28514442
PON2_HUMAN	PON2	physical	28514442
PIGT_HUMAN	PIGT	physical	28514442
HECD3_HUMAN	HECTD3	physical	28514442
ZZEF1_HUMAN	ZZEF1	physical	28514442
UBR5_HUMAN	UBR5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615696: Dowling-Degos disease 4 (DDD4)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.