CGAT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CGAT2_HUMAN
• UniProt AC: Q8N6G5
• Protein Name: Chondroitin sulfate N-acetylgalactosaminyltransferase 2
• Gene Name: CSGALNACT2
• Organism: Homo sapiens (Human).
• Sequence Length: 542
• Subcellular Localization: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein .
• Protein Description: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains..
• Protein Sequence: MPRRGLILHTRTHWLLLGLALLCSLVLFMYLLECAPQTDGNASLPGVVGENYGKEYYQALLQEQEEHYQTRATSLKRQIAQLKQELQEMSEKMRSLQERRNVGANGIGYQSNKEQAPSDLLEFLHSQIDKAEVSIGAKLPSEYGVIPFESFTLMKVFQLEMGLTRHPEEKPVRKDKRDELVEVIEAGLEVINNPDEDDEQEDEEGPLGEKLIFNENDFVEGYYRTERDKGTQYELFFKKADLTEYRHVTLFRPFGPLMKVKSEMIDITRSIINIIVPLAERTEAFVQFMQNFRDVCIHQDKKIHLTVVYFGKEGLSKVKSILESVTSESNFHNYTLVSLNEEFNRGRGLNVGARAWDKGEVLMFFCDVDIYFSAEFLNSCRLNAEPGKKVFYPVVFSLYNPAIVYANQEVPPPVEQQLVHKKDSGFWRDFGFGMTCQYRSDFLTIGGFDMEVKGWGGEDVHLYRKYLHGDLIVIRTPVPGLFHLWHEKRCADELTPEQYRMCIQSKAMNEASHSHLGMLVFREEIETHLHKQAYRTNSEAVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	N-linked_Glycosylation	CAPQTDGNASLPGVV HCCCCCCCCCCCCCC	29.21	UniProtKB CARBOHYD
43	O-linked_Glycosylation	PQTDGNASLPGVVGE CCCCCCCCCCCCCCC	38.81	OGP
68	Phosphorylation	LQEQEEHYQTRATSL HHHHHHHHHHHHHHH	18.17	26074081
70	Phosphorylation	EQEEHYQTRATSLKR HHHHHHHHHHHHHHH	18.33	26074081
90	Phosphorylation	KQELQEMSEKMRSLQ HHHHHHHHHHHHHHH	33.06	29449344
92	Ubiquitination	ELQEMSEKMRSLQER HHHHHHHHHHHHHHH	32.10	-
243	Phosphorylation	FFKKADLTEYRHVTL EEEECCCCCEEEEEE	31.36	29514088
245	Phosphorylation	KKADLTEYRHVTLFR EECCCCCEEEEEEEE	10.77	29514088
249	Phosphorylation	LTEYRHVTLFRPFGP CCCEEEEEEEECCCC	17.66	29514088
262	Phosphorylation	GPLMKVKSEMIDITR CCHHHHHHHHHHHHH	35.07	29759185
268	Phosphorylation	KSEMIDITRSIINII HHHHHHHHHHHHHHH	18.02	29759185
333	N-linked_Glycosylation	TSESNFHNYTLVSLN CCCCCCCCEEEEECC	27.61	UniProtKB CARBOHYD
476	Phosphorylation	GDLIVIRTPVPGLFH CCEEEEECCCCCHHH	19.95	24114839
505	Phosphorylation	QYRMCIQSKAMNEAS HHHHHHHHHHHHHHC	11.50	-
536	Phosphorylation	LHKQAYRTNSEAVG- HHHHHHHCCCCCCC-	30.35	-
538	Phosphorylation	KQAYRTNSEAVG--- HHHHHCCCCCCC---	26.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CGAT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CGAT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CGAT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYNE4_HUMAN	SYNE4	physical	25416956
MCLN1_HUMAN	MCOLN1	physical	28514442
TRI59_HUMAN	TRIM59	physical	28514442
GOSR2_HUMAN	GOSR2	physical	28514442
CHSS1_HUMAN	CHSY1	physical	28514442
ZNT5_HUMAN	SLC30A5	physical	28514442
MANEL_HUMAN	MANEAL	physical	28514442
TPST2_HUMAN	TPST2	physical	28514442
EXTL2_HUMAN	EXTL2	physical	28514442
UTP15_HUMAN	UTP15	physical	28514442
SULF2_HUMAN	SULF2	physical	28514442
ZNT6_HUMAN	SLC30A6	physical	28514442
SUN2_HUMAN	SUN2	physical	28514442
P2RX4_HUMAN	P2RX4	physical	28514442
NADE_HUMAN	NADSYN1	physical	28514442
MANEA_HUMAN	MANEA	physical	28514442
ZNT1_HUMAN	SLC30A1	physical	28514442
TM214_HUMAN	TMEM214	physical	28514442
CLAP2_HUMAN	CLASP2	physical	28514442
LMBD1_HUMAN	LMBRD1	physical	28514442
GOSR1_HUMAN	GOSR1	physical	28514442
STX5_HUMAN	STX5	physical	28514442
LRC57_HUMAN	LRRC57	physical	28514442
F213A_HUMAN	FAM213A	physical	28514442
GOLI4_HUMAN	GOLIM4	physical	28514442
TMTC4_HUMAN	TMTC4	physical	28514442
K2013_HUMAN	KIAA2013	physical	28514442
NDUB9_HUMAN	NDUFB9	physical	28514442
TMX4_HUMAN	TMX4	physical	28514442
CCDC8_HUMAN	CCDC8	physical	28514442
FKRP_HUMAN	FKRP	physical	28514442
PRAF2_HUMAN	PRAF2	physical	28514442
ATF1_HUMAN	ATF1	physical	28514442
SUN1_HUMAN	SUN1	physical	28514442
EMC3_HUMAN	EMC3	physical	28514442
NDUB3_HUMAN	NDUFB3	physical	28514442
B3GA3_HUMAN	B3GAT3	physical	28514442
IQCB1_HUMAN	IQCB1	physical	28514442
ADPGK_HUMAN	ADPGK	physical	28514442
CGT_HUMAN	UGT8	physical	28514442
NDUC2_HUMAN	NDUFC2	physical	28514442
CREB1_HUMAN	CREB1	physical	28514442
EMC4_HUMAN	EMC4	physical	28514442
FUT8_HUMAN	FUT8	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.