NADE_HUMAN - dbPTM
NADE_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NADE_HUMAN
UniProt AC Q6IA69
Protein Name Glutamine-dependent NAD(+) synthetase
Gene Name NADSYN1
Organism Homo sapiens (Human).
Sequence Length 706
Subcellular Localization
Protein Description
Protein Sequence MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWTPHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGVDSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMASKNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLALQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIGGISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSVYGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAENYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4 (in isoform 2)Phosphorylation-36.2129507054
12 (in isoform 2)Phosphorylation-5.4929507054
20 (in isoform 2)Phosphorylation-47.0029507054
21 (in isoform 2)Phosphorylation-39.8929116813
28UbiquitinationGNLQRILKSIEIAKN
CHHHHHHHHHHHHHH		47.1929901268
29PhosphorylationNLQRILKSIEIAKNR
HHHHHHHHHHHHHHC		23.2422496350
34UbiquitinationLKSIEIAKNRGARYR
HHHHHHHHHCCCCCC		53.4927667366
161UbiquitinationETVPFGDAVLVTWDT
CCCCCCCEEEEEECC		9.27-
211PhosphorylationQVLRKANTRVDLVTM
HHHHHCCCCEEEEEE		36.6129978859
217PhosphorylationNTRVDLVTMVTSKNG
CCCEEEEEEEECCCC		17.1429978859
218SulfoxidationTRVDLVTMVTSKNGG
CCEEEEEEEECCCCC		2.1121406390
220PhosphorylationVDLVTMVTSKNGGIY
EEEEEEEECCCCCEE		24.1429978859
221PhosphorylationDLVTMVTSKNGGIYL
EEEEEEECCCCCEEE		16.8329978859
227PhosphorylationTSKNGGIYLLANQKG
ECCCCCEEEEECCCC		10.0329978859
382UbiquitinationQVCEAVRSGNEEVLA
HHHHHHHCCCHHHHH		39.10-
389UbiquitinationSGNEEVLADVRTIVN
CCCHHHHHHHHHHHH		20.59-
421UbiquitinationTTCYMASKNSSQETC
HHHHHHCCCCCHHHH		51.8422505724
423PhosphorylationCYMASKNSSQETCTR
HHHHCCCCCHHHHHH		36.82-
424PhosphorylationYMASKNSSQETCTRA
HHHCCCCCHHHHHHH		41.24-
427PhosphorylationSKNSSQETCTRAREL
CCCCCHHHHHHHHHH		16.13-
429PhosphorylationNSSQETCTRARELAQ
CCCHHHHHHHHHHHH		34.48-
462PhosphorylationMGIFSLVTGKSPLFA
HHHHHHHHCCCCCHH		44.15-
500PhosphorylationAYLFAQLSLWSRGVH
HHHHHHHHHHHCCCC		18.7328122231
503PhosphorylationFAQLSLWSRGVHGGL
HHHHHHHHCCCCCCE		25.1728122231
521PhosphorylationGSANVDESLLGYLTK
CCCCCCHHHHHHHHH		25.1624719451
532PhosphorylationYLTKYDCSSADINPI
HHHHCCCCCCCCCCC		26.1830631047
533PhosphorylationLTKYDCSSADINPIG
HHHCCCCCCCCCCCC		35.9730631047
544UbiquitinationNPIGGISKTDLRAFV
CCCCCCCHHHHHHHH		44.1033845483
637UbiquitinationRQVADKVKRFFSKYS
HHHHHHHHHHHHHHC		49.5923000965
641PhosphorylationDKVKRFFSKYSMNRH
HHHHHHHHHHCCCCC		28.1523532336
642UbiquitinationKVKRFFSKYSMNRHK
HHHHHHHHHCCCCCC		35.8721890473
642UbiquitinationKVKRFFSKYSMNRHK
HHHHHHHHHCCCCCC		35.8723000965
643PhosphorylationVKRFFSKYSMNRHKM
HHHHHHHHCCCCCCC		16.38-
644PhosphorylationKRFFSKYSMNRHKMT
HHHHHHHCCCCCCCC		17.20-
649UbiquitinationKYSMNRHKMTTLTPA
HHCCCCCCCCCCCCC		34.4021963094
649UbiquitinationKYSMNRHKMTTLTPA
HHCCCCCCCCCCCCC		34.4021890473
657PhosphorylationMTTLTPAYHAENYSP
CCCCCCCCCCCCCCC		11.63-
701PhosphorylationLERAEPQSLDGVD--
HHHCCCCCCCCCC--		38.8624719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NADE_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NADE_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NADE_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00130L-Glutamine
Regulatory Network of NADE_HUMAN

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Related Literatures of Post-Translational Modification

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