| UniProt ID | FUT8_HUMAN | |
|---|---|---|
| UniProt AC | Q9BYC5 | |
| Protein Name | Alpha-(1,6)-fucosyltransferase | |
| Gene Name | FUT8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 575 | |
| Subcellular Localization |
Golgi apparatus, Golgi stack membrane Single-pass type II membrane protein. Membrane-bound form in trans cisternae of Golgi.. |
|
| Protein Description | Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.. | |
| Protein Sequence | MRPWTGSWRWIMLILFAWGTLLFYIGGHLVRDNDHPDHSSRELSKILAKLERLKQQNEDLRRMAESLRIPEGPIDQGPAIGRVRVLEEQLVKAKEQIENYKKQTRNGLGKDHEILRRRIENGAKELWFFLQSELKKLKNLEGNELQRHADEFLLDLGHHERSIMTDLYYLSQTDGAGDWREKEAKDLTELVQRRITYLQNPKDCSKAKKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRTLILESQNWRYATGGWETVFRPVSETCTDRSGISTGHWSGEVKDKNVQVVELPIVDSLHPRPPYLPLAVPEDLADRLVRVHGDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKHPVIGVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQVDKKRVYLATDDPSLLKEAKTKYPNYEFISDNSISWSAGLHNRYTENSLRGVILDIHFLSQADFLVCTFSSQVCRVAYEIMQTLHPDASANFHSLDDIYYFGGQNAHNQIAIYAHQPRTADEIPMEPGDIIGVAGNHWDGYSKGVNRKLGRTGLYPSYKVREKIETVKYPTYPEAEK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 49 | Ubiquitination | ELSKILAKLERLKQQ HHHHHHHHHHHHHHH | 47.65 | - | |
| 173 | Phosphorylation | DLYYLSQTDGAGDWR HHHHHHCCCCCCCCC | 32.78 | 27050516 | |
| 252 | Phosphorylation | SQNWRYATGGWETVF ECCEEECCCCCEEEE | 27.56 | 22210691 | |
| 270 | Phosphorylation | SETCTDRSGISTGHW CCCCCCCCCCCCCCC | 43.20 | 27732954 | |
| 273 | Phosphorylation | CTDRSGISTGHWSGE CCCCCCCCCCCCCCC | 31.68 | 27732954 | |
| 274 | Phosphorylation | TDRSGISTGHWSGEV CCCCCCCCCCCCCCC | 31.01 | 27732954 | |
| 278 | Phosphorylation | GISTGHWSGEVKDKN CCCCCCCCCCCCCCC | 21.28 | 25849741 | |
| 329 | Phosphorylation | DPAVWWVSQFVKYLI CHHHHHHHHHHHHHH | 12.27 | - | |
| 412 | Phosphorylation | YLATDDPSLLKEAKT EEECCCHHHHHHHHH | 54.02 | 24719451 | |
| 421 | Phosphorylation | LKEAKTKYPNYEFIS HHHHHHHCCCCEECC | 11.27 | 29083192 | |
| 424 | Phosphorylation | AKTKYPNYEFISDNS HHHHCCCCEECCCCC | 14.01 | 29083192 | |
| 428 | Phosphorylation | YPNYEFISDNSISWS CCCCEECCCCCCCCC | 35.74 | 29083192 | |
| 564 | O-linked_Glycosylation | KVREKIETVKYPTYP HHHHHHEECCCCCCC | 26.27 | 55824409 | |
| 569 | O-linked_Glycosylation | IETVKYPTYPEAEK- HEECCCCCCCCCCC- | 48.93 | OGP |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FUT8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FUT8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FUT8_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PM34_HUMAN | SLC25A17 | physical | 22939629 | |
| RL27_HUMAN | RPL27 | physical | 22939629 | |
| MA2A2_HUMAN | MAN2A2 | physical | 28514442 | |
| STS_HUMAN | STS | physical | 28514442 | |
| MA2A1_HUMAN | MAN2A1 | physical | 28514442 | |
| PLTP_HUMAN | PLTP | physical | 28514442 | |
| MGAT1_HUMAN | MGAT1 | physical | 28514442 | |
| ITAV_HUMAN | ITGAV | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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