PM34_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PM34_HUMAN
• UniProt AC: O43808
• Protein Name: Peroxisomal membrane protein PMP34
• Gene Name: SLC25A17
• Organism: Homo sapiens (Human).
• Sequence Length: 307
• Subcellular Localization: Cytoplasm. Peroxisome membrane; Multi-pass membrane protein.
• Protein Description: Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro..
• Protein Sequence: MASVLSYESLVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEGLLAPYRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMGLKRAHQH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	AVAGAVGSVTAMTVF HHHHHHCCEEEEEEE	15.08	24719451
42	Ubiquitination	LRLQVDEKRKSKTTH HHEEECHHHCCCCCE	61.74	-
95	Ubiquitination	SLKALWVKGQHSTTG CEEEEEECCCCCCCC	41.07	-
99	Phosphorylation	LWVKGQHSTTGKDLV EEECCCCCCCCCHHH	21.56	-
100	Phosphorylation	WVKGQHSTTGKDLVV EECCCCCCCCCHHHH	37.13	-
101	Phosphorylation	VKGQHSTTGKDLVVG ECCCCCCCCCHHHHH	45.29	-
127	Phosphorylation	TPLWVVNTRLKLQGA CCHHHHHHHHHCCCC	26.26	-
130	Acetylation	WVVNTRLKLQGAKFR HHHHHHHHCCCCCCC	35.16	25953088
130	Ubiquitination	WVVNTRLKLQGAKFR HHHHHHHHCCCCCCC	35.16	-
135	Ubiquitination	RLKLQGAKFRNEDIV HHHCCCCCCCCCCCC	52.24	-
147	Ubiquitination	DIVPTNYKGIIDAFH CCCCCCCHHHHHHHH	45.78	-
228	Phosphorylation	YPLQTVQSILRFGRH CCHHHHHHHHHHCCC	21.18	24719451
246	Phosphorylation	PENRTLGSLRNILYL CCCCHHHHHHHHHHH	27.54	24719451
268	Ubiquitination	FGIMGLYKGLEAKLL HCCCHHHHHHHHHHH	63.16	21890473
292	Phosphorylation	FLVYEKLTAATFTVM HHHHHHHHHHHHHHH	25.88	25072903
295	Phosphorylation	YEKLTAATFTVMGLK HHHHHHHHHHHHHHH	19.85	25072903
297	Phosphorylation	KLTAATFTVMGLKRA HHHHHHHHHHHHHHH	12.77	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PM34_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PM34_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PM34_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
QCR7_HUMAN	UQCRB	physical	22939629
SAM50_HUMAN	SAMM50	physical	22939629

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.