STS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STS_HUMAN
• UniProt AC: P08842
• Protein Name: Steryl-sulfatase
• Gene Name: STS
• Organism: Homo sapiens (Human).
• Sequence Length: 583
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Conversion of sulfated steroid precursors to estrogens during pregnancy..
• Protein Sequence: MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	N-linked_Glycosylation	GDPGCYGNKTIRTPN CCCCCCCCCCCCCCC	16.30	12657638
75	3-oxoalanine (Cys)	HLAASPLCTPSRAAF HHHCCCCCCCCHHHH	6.29	-
75	Oxidation	HLAASPLCTPSRAAF HHHCCCCCCCCHHHH	6.29	12657638
123	Ubiquitination	ITFAKLLKDQGYSTA HHHHHHHHHCCCCEE	59.44	-
259	N-linked_Glycosylation	QQPMSYDNLTQRLTV CCCCCCCCHHHHHHH	36.43	12657638
368	Malonylation	NGIYKGGKANNWEGG CCCCCCCCCCCCCCC	57.52	26320211
393	Ubiquitination	RVIQAGQKIDEPTSN HHCCCCCCCCCCCCC	51.73	-
409	Ubiquitination	DIFPTVAKLAGAPLP CCHHHHHHHCCCCCC	34.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RETR2_HUMAN	FAM134A	physical	28514442
SUMF1_HUMAN	SUMF1	physical	28514442
JAG2_HUMAN	JAG2	physical	28514442
ALG9_HUMAN	ALG9	physical	28514442
ZDHC6_HUMAN	ZDHHC6	physical	28514442
ZNT1_HUMAN	SLC30A1	physical	28514442
LRC8A_HUMAN	LRRC8A	physical	28514442
CISD2_HUMAN	CISD2	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
AT11C_HUMAN	ATP11C	physical	28514442
CXA1_HUMAN	GJA1	physical	28514442
TM214_HUMAN	TMEM214	physical	28514442
ABCB8_HUMAN	ABCB8	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
MBOA7_HUMAN	MBOAT7	physical	28514442
GOGA5_HUMAN	GOLGA5	physical	28514442
SIDT2_HUMAN	SIDT2	physical	28514442
GEPH_HUMAN	GPHN	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00134: X-linked ichthyosis (XLI)
• OMIM Disease
• 308100: Ichthyosis, X-linked (IXL)
• Kegg Drug
• D09915: Irosustat (USAN/INN)
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Structure of human estrone sulfatase suggests functional roles ofmembrane association.";
Hernandez-Guzman F.G., Higashiyama T., Pangborn W., Osawa Y.,Ghosh D.;
J. Biol. Chem. 278:22989-22997(2003).
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH CALCIUM IONS,COFACTOR, TRANSMEMBRANE TOPOLOGY, ACTIVE SITE, AND GLYCOSYLATION ATASN-47 AND ASN-259.
PubMed: 12657638

"Cloning and expression of human steroid-sulfatase. Membrane topology,glycosylation, and subcellular distribution in BHK-21 cells.";
Stein C., Hille A., Seidel J., Rijnbout S., Waheed A., Schmidt B.,Geuze H., von Figura K.;
J. Biol. Chem. 264:13865-13872(1989).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION ATASN-47 AND ASN-259, AND LACK OF GLYCOSYLATION AT ASN-333 AND ASN-459.
PubMed: 2668275