ZDHC6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZDHC6_HUMAN
• UniProt AC: Q9H6R6
• Protein Name: Palmitoyltransferase ZDHHC6 {ECO:0000305}
• Gene Name: ZDHHC6 {ECO:0000312|HGNC:HGNC:19160}
• Organism: Homo sapiens (Human).
• Sequence Length: 413
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . When not palmitoylated, accumulates to dot-like structures in the endoplasmic reticulum (PubMed:28826475).
• Protein Description: Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. [PubMed: 22314232]
• Protein Sequence: MGTFCSVIKFENLQELKRLCHWGPIIALGVIAICSTMAMIDSVLWYWPLHTTGGSVNFIMLINWTVMILYNYFNAMFVGPGFVPLGWKPEISQDTMYLQYCKVCQAYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGYQNHASFTLFLLLAPLGCIHAAFIFVMTMYTQLYHRLSFGWNTVKIDMSAARRDPLPIVPFGLAAFATTLFALGLALGTTIAVGMLFFIQMKIILRNKTSIESWIEEKAKDRIQYYQLDEVFVFPYDMGSRWRNFKQVFTWSGVPEGDGLEWPVREGCHQYSLTIEQLKQKADKRVRSVRYKVIEDYSGACCPLNKGIKTFFTSPCTEEPRIQLQKGEFILATRGLRYWLYGDKILDDSFIEGVSRIRGWFPRKCVEKCPCDAETDQAPEGEKKNR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
182	Ubiquitination	SFGWNTVKIDMSAAR HCCCCEEEEEHHHHH	30.83	-
240	Phosphorylation	RNKTSIESWIEEKAK HCCCCHHHHHHHHHH	31.51	-
241 (in isoform 2)	Ubiquitination	-	6.82	21906983
245	Ubiquitination	IESWIEEKAKDRIQY HHHHHHHHHHHHCEE	48.20	21906983
245 (in isoform 1)	Ubiquitination	-	48.20	21906983
253	Phosphorylation	AKDRIQYYQLDEVFV HHHHCEEEEECEEEE	6.04	23532336
269 (in isoform 2)	Ubiquitination	-	10.98	21906983
273 (in isoform 1)	Ubiquitination	-	49.45	21906983
273	Ubiquitination	GSRWRNFKQVFTWSG CCCCCCCEEEEEECC	49.45	21906983
315	Phosphorylation	KADKRVRSVRYKVIE HHHHHHHHHHEEEEE	14.21	-
328	S-palmitoylation	IEDYSGACCPLNKGI EECCCCCEECCCCCC	2.54	28826475
329	S-palmitoylation	EDYSGACCPLNKGIK ECCCCCEECCCCCCC	4.21	28826475
336	Ubiquitination	CPLNKGIKTFFTSPC ECCCCCCCEEEECCC	48.20	-
343	S-palmitoylation	KTFFTSPCTEEPRIQ CEEEECCCCCCCCEE	8.18	28826475
349 (in isoform 2)	Ubiquitination	-	7.59	21906983
353	Ubiquitination	EPRIQLQKGEFILAT CCCEEECCCCEEEEE	69.84	21906983
353 (in isoform 1)	Ubiquitination	-	69.84	21906983
367 (in isoform 2)	Ubiquitination	-	2.25	21906983
371	Ubiquitination	RYWLYGDKILDDSFI CHHHHCCCCCCCHHH	40.58	2190698
371 (in isoform 1)	Ubiquitination	-	40.58	21906983
395	Acetylation	FPRKCVEKCPCDAET CCHHHHHCCCCCCCC	24.07	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZDHC6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
328	C	Palmitoylation	Palmitoylation at Cys-328 accelerates the turnover of ZDHHC6.	28826475

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZDHC6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZDHC6_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.