UniProt ID | JAG2_HUMAN | |
---|---|---|
UniProt AC | Q9Y219 | |
Protein Name | Protein jagged-2 | |
Gene Name | JAG2 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 1238 | |
Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
Protein Description | Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).. | |
Protein Sequence | MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
35 | Phosphorylation | GYFELQLSALRNVNG CCHHHHHHHHHCCCC | 16.58 | - | |
153 | N-linked_Glycosylation | VEAWDWDNDTTPNEE EEEECCCCCCCCCHH | 44.25 | UniProtKB CARBOHYD | |
202 | Phosphorylation | RVRCDENYYSATCNK EEECCCCEEEEECCC | 9.21 | 25884760 | |
203 | Phosphorylation | VRCDENYYSATCNKF EECCCCEEEEECCCC | 11.92 | 25884760 | |
570 | N-linked_Glycosylation | PDDFGGKNCSVPREP CCCCCCCCCCCCCCC | 26.94 | UniProtKB CARBOHYD | |
619 | N-linked_Glycosylation | CVSQPGGNFSCICDS EECCCCCCEEEEECC | 31.41 | UniProtKB CARBOHYD | |
719 | Phosphorylation | REFQCDAYTCSNGGT CCCCCCEEEECCCCE | 8.60 | 30576142 | |
722 | Phosphorylation | QCDAYTCSNGGTCYD CCCEEEECCCCEEEC | 30.61 | 30576142 | |
728 | Phosphorylation | CSNGGTCYDSGDTFR ECCCCEEECCCCCEE | 17.00 | 30576142 | |
752 | N-linked_Glycosylation | STCAVAKNSSCLPNP CCEEEECCCCCCCCC | 29.44 | UniProtKB CARBOHYD | |
1031 | Phosphorylation | VEVAVSFSPARDLPD EEEEEECCCCCCCCC | 15.33 | 24945436 | |
1058 | N-linked_Glycosylation | AAITQRGNSSLLLAV HHHHHHCCCEEEEEE | 30.52 | UniProtKB CARBOHYD | |
1059 | Phosphorylation | AITQRGNSSLLLAVT HHHHHCCCEEEEEEE | 25.78 | - | |
1060 | Phosphorylation | ITQRGNSSLLLAVTE HHHHCCCEEEEEEEE | 27.34 | - | |
1066 | Phosphorylation | SSLLLAVTEVKVETV CEEEEEEEEEEEEEE | 29.47 | - | |
1123 | Phosphorylation | SRLPREESANNQWAP HCCCCHHHCCCCCCC | 31.38 | 25954137 | |
1149 | Phosphorylation | GGHKDVLYQCKNFTP CCCCCHHHHCCCCCC | 16.24 | 25884760 | |
1155 | Phosphorylation | LYQCKNFTPPPRRAD HHHCCCCCCCCCCHH | 44.25 | 23911959 | |
1202 | Phosphorylation | KFLSHKFTKDPGRSP HHHHCCCCCCCCCCC | 39.06 | 23312004 | |
1208 | Phosphorylation | FTKDPGRSPGRPAHW CCCCCCCCCCCCCCC | 37.31 | 23403867 | |
1217 | Phosphorylation | GRPAHWASGPKVDNR CCCCCCCCCCCCCHH | 50.89 | 23312004 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of JAG2_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of JAG2_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of JAG2_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
MIB2_HUMAN | MIB2 | physical | 15920166 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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