JAG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JAG2_HUMAN
• UniProt AC: Q9Y219
• Protein Name: Protein jagged-2
• Gene Name: JAG2
• Organism: Homo sapiens (Human).
• Sequence Length: 1238
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity)..
• Protein Sequence: MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	GYFELQLSALRNVNG CCHHHHHHHHHCCCC	16.58	-
153	N-linked_Glycosylation	VEAWDWDNDTTPNEE EEEECCCCCCCCCHH	44.25	UniProtKB CARBOHYD
202	Phosphorylation	RVRCDENYYSATCNK EEECCCCEEEEECCC	9.21	25884760
203	Phosphorylation	VRCDENYYSATCNKF EECCCCEEEEECCCC	11.92	25884760
570	N-linked_Glycosylation	PDDFGGKNCSVPREP CCCCCCCCCCCCCCC	26.94	UniProtKB CARBOHYD
619	N-linked_Glycosylation	CVSQPGGNFSCICDS EECCCCCCEEEEECC	31.41	UniProtKB CARBOHYD
719	Phosphorylation	REFQCDAYTCSNGGT CCCCCCEEEECCCCE	8.60	30576142
722	Phosphorylation	QCDAYTCSNGGTCYD CCCEEEECCCCEEEC	30.61	30576142
728	Phosphorylation	CSNGGTCYDSGDTFR ECCCCEEECCCCCEE	17.00	30576142
752	N-linked_Glycosylation	STCAVAKNSSCLPNP CCEEEECCCCCCCCC	29.44	UniProtKB CARBOHYD
1031	Phosphorylation	VEVAVSFSPARDLPD EEEEEECCCCCCCCC	15.33	24945436
1058	N-linked_Glycosylation	AAITQRGNSSLLLAV HHHHHHCCCEEEEEE	30.52	UniProtKB CARBOHYD
1059	Phosphorylation	AITQRGNSSLLLAVT HHHHHCCCEEEEEEE	25.78	-
1060	Phosphorylation	ITQRGNSSLLLAVTE HHHHCCCEEEEEEEE	27.34	-
1066	Phosphorylation	SSLLLAVTEVKVETV CEEEEEEEEEEEEEE	29.47	-
1123	Phosphorylation	SRLPREESANNQWAP HCCCCHHHCCCCCCC	31.38	25954137
1149	Phosphorylation	GGHKDVLYQCKNFTP CCCCCHHHHCCCCCC	16.24	25884760
1155	Phosphorylation	LYQCKNFTPPPRRAD HHHCCCCCCCCCCHH	44.25	23911959
1202	Phosphorylation	KFLSHKFTKDPGRSP HHHHCCCCCCCCCCC	39.06	23312004
1208	Phosphorylation	FTKDPGRSPGRPAHW CCCCCCCCCCCCCCC	37.31	23403867
1217	Phosphorylation	GRPAHWASGPKVDNR CCCCCCCCCCCCCHH	50.89	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JAG2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JAG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JAG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIB2_HUMAN	MIB2	physical	15920166

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.