JAG2_HUMAN - dbPTM
JAG2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID JAG2_HUMAN
UniProt AC Q9Y219
Protein Name Protein jagged-2
Gene Name JAG2
Organism Homo sapiens (Human).
Sequence Length 1238
Subcellular Localization Membrane
Single-pass type I membrane protein.
Protein Description Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity)..
Protein Sequence MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
35PhosphorylationGYFELQLSALRNVNG
CCHHHHHHHHHCCCC
16.58-
153N-linked_GlycosylationVEAWDWDNDTTPNEE
EEEECCCCCCCCCHH
44.25UniProtKB CARBOHYD
202PhosphorylationRVRCDENYYSATCNK
EEECCCCEEEEECCC
9.2125884760
203PhosphorylationVRCDENYYSATCNKF
EECCCCEEEEECCCC
11.9225884760
570N-linked_GlycosylationPDDFGGKNCSVPREP
CCCCCCCCCCCCCCC
26.94UniProtKB CARBOHYD
619N-linked_GlycosylationCVSQPGGNFSCICDS
EECCCCCCEEEEECC
31.41UniProtKB CARBOHYD
719PhosphorylationREFQCDAYTCSNGGT
CCCCCCEEEECCCCE
8.6030576142
722PhosphorylationQCDAYTCSNGGTCYD
CCCEEEECCCCEEEC
30.6130576142
728PhosphorylationCSNGGTCYDSGDTFR
ECCCCEEECCCCCEE
17.0030576142
752N-linked_GlycosylationSTCAVAKNSSCLPNP
CCEEEECCCCCCCCC
29.44UniProtKB CARBOHYD
1031PhosphorylationVEVAVSFSPARDLPD
EEEEEECCCCCCCCC
15.3324945436
1058N-linked_GlycosylationAAITQRGNSSLLLAV
HHHHHHCCCEEEEEE
30.52UniProtKB CARBOHYD
1059PhosphorylationAITQRGNSSLLLAVT
HHHHHCCCEEEEEEE
25.78-
1060PhosphorylationITQRGNSSLLLAVTE
HHHHCCCEEEEEEEE
27.34-
1066PhosphorylationSSLLLAVTEVKVETV
CEEEEEEEEEEEEEE
29.47-
1123PhosphorylationSRLPREESANNQWAP
HCCCCHHHCCCCCCC
31.3825954137
1149PhosphorylationGGHKDVLYQCKNFTP
CCCCCHHHHCCCCCC
16.2425884760
1155PhosphorylationLYQCKNFTPPPRRAD
HHHCCCCCCCCCCHH
44.2523911959
1202PhosphorylationKFLSHKFTKDPGRSP
HHHHCCCCCCCCCCC
39.0623312004
1208PhosphorylationFTKDPGRSPGRPAHW
CCCCCCCCCCCCCCC
37.3123403867
1217PhosphorylationGRPAHWASGPKVDNR
CCCCCCCCCCCCCHH
50.8923312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of JAG2_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of JAG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of JAG2_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MIB2_HUMANMIB2physical
15920166

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of JAG2_HUMAN

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Related Literatures of Post-Translational Modification

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