| UniProt ID | LMBR1_HUMAN | |
|---|---|---|
| UniProt AC | Q8WVP7 | |
| Protein Name | Limb region 1 protein homolog | |
| Gene Name | LMBR1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 490 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. |
|
| Protein Description | Putative membrane receptor.. | |
| Protein Sequence | MEGQDEVSAREQHFHSQVRESTICFLLFAILYVVSYFIITRYKRKSDEQEDEDAIVNRISLFLSTFTLAVSAGAVLLLPFSIISNEILLSFPQNYYIQWLNGSLIHGLWNLASLFSNLCLFVLMPFAFFFLESEGFAGLKKGIRARILETLVMLLLLALLILGIVWVASALIDNDAASMESLYDLWEFYLPYLYSCISLMGCLLLLLCTPVGLSRMFTVMGQLLVKPTILEDLDEQIYIITLEEEALQRRLNGLSSSVEYNIMELEQELENVKTLKTKLERRKKASAWERNLVYPAVMVLLLIETSISVLLVACNILCLLVDETAMPKGTRGPGIGNASLSTFGFVGAALEIILIFYLMVSSVVGFYSLRFFGNFTPKKDDTTMTKIIGNCVSILVLSSALPVMSRTLGITRFDLLGDFGRFNWLGNFYIVLSYNLLFAIVTTLCLVRKFTSAVREELFKALGLHKLHLPNTSRDSETAKPSVNGHQKAL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | Ubiquitination | IITRYKRKSDEQEDE HHHHHHCCCCCCCCH | 59.09 | 2190698 | |
| 45 (in isoform 1) | Ubiquitination | - | 59.09 | 21906983 | |
| 45 (in isoform 2) | Ubiquitination | - | 59.09 | 21906983 | |
| 45 (in isoform 3) | Ubiquitination | - | 59.09 | 21906983 | |
| 286 | Phosphorylation | LERRKKASAWERNLV HHHHHHHHHHHHHCH | 42.68 | - | |
| 368 | Phosphorylation | SSVVGFYSLRFFGNF HHHHHHHHHHHCCCC | 15.71 | 24719451 | |
| 451 | Phosphorylation | LCLVRKFTSAVREEL HHHHHHHHHHHHHHH | 20.86 | 24719451 | |
| 452 | Phosphorylation | CLVRKFTSAVREELF HHHHHHHHHHHHHHH | 28.09 | 24719451 | |
| 466 | Ubiquitination | FKALGLHKLHLPNTS HHHHCCHHCCCCCCC | 42.52 | 29967540 | |
| 472 | Phosphorylation | HKLHLPNTSRDSETA HHCCCCCCCCCCCCC | 24.17 | - | |
| 473 | Phosphorylation | KLHLPNTSRDSETAK HCCCCCCCCCCCCCC | 40.50 | 28555341 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LMBR1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LMBR1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LMBR1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of LMBR1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00629 | Acheiropodia | |||||
| H00855 | Triphalangeal thumb, including: Triphalangeal thumb; Triphalangeal thumb-polysyndactyly syndrome | |||||
| H01095 | Syndactyly | |||||
| OMIM Disease | ||||||
| 174500 | Preaxial polydactyly 2 (PPD2) | |||||
| 200500 | Acheiropody (ACHP) | |||||
| 186200 | Syndactyly 4 (SDTY4) | |||||
| 188740 | Hypoplasia or aplasia of tibia with polydactyly (THYP) | |||||
| 135750 | Laurin-Sandrow syndrome (LSS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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