CHSS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHSS1_HUMAN
• UniProt AC: Q86X52
• Protein Name: Chondroitin sulfate synthase 1
• Gene Name: CHSY1
• Organism: Homo sapiens (Human).
• Sequence Length: 802
• Subcellular Localization: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Secreted .
• Protein Description: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling..
• Protein Sequence: MAARGRRAWLSVLLGLVLGFVLASRLVLPRASELKRAGPRRRASPEGCRSGQAAASQAGGARGDARGAQLWPPGSDPDGGPRDRNFLFVGVMTAQKYLQTRAVAAYRTWSKTIPGKVQFFSSEGSDTSVPIPVVPLRGVDDSYPPQKKSFMMLKYMHDHYLDKYEWFMRADDDVYIKGDRLENFLRSLNSSEPLFLGQTGLGTTEEMGKLALEPGENFCMGGPGVIMSREVLRRMVPHIGKCLREMYTTHEDVEVGRCVRRFAGVQCVWSYEMQQLFYENYEQNKKGYIRDLHNSKIHQAITLHPNKNPPYQYRLHSYMLSRKISELRHRTIQLHREIVLMSKYSNTEIHKEDLQLGIPPSFMRFQPRQREEILEWEFLTGKYLYSAVDGQPPRRGMDSAQREALDDIVMQVMEMINANAKTRGRIIDFKEIQYGYRRVNPMYGAEYILDLLLLYKKHKGKKMTVPVRRHAYLQQTFSKIQFVEHEELDAQELAKRINQESGSLSFLSNSLKKLVPFQLPGSKSEHKEPKDKKINILIPLSGRFDMFVRFMGNFEKTCLIPNQNVKLVVLLFNSDSNPDKAKQVELMRDYRIKYPKADMQILPVSGEFSRALALEVGSSQFNNESLLFFCDVDLVFTTEFLQRCRANTVLGQQIYFPIIFSQYDPKIVYSGKVPSDNHFAFTQKTGFWRNYGFGITCIYKGDLVRVGGFDVSIQGWGLEDVDLFNKVVQAGLKTFRSQEVGVVHVHHPVFCDPNLDPKQYKMCLGSKASTYGSTQQLAEMWLEKNDPSYSKSSNNNGSVRTA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Phosphorylation	FLFVGVMTAQKYLQT CEEEEEEHHHHHHHH	24.43	27794612
142	Phosphorylation	PLRGVDDSYPPQKKS ECCCCCCCCCCCHHC	34.77	-
143	Phosphorylation	LRGVDDSYPPQKKSF CCCCCCCCCCCHHCH	26.40	-
189	N-linked_Glycosylation	ENFLRSLNSSEPLFL HHHHHHCCCCCCEEC	44.74	UniProtKB CARBOHYD
325	Phosphorylation	YMLSRKISELRHRTI HHHHHHHHHHHHHHH	33.35	24719451
344	Phosphorylation	EIVLMSKYSNTEIHK HHHHHHCCCCCEECH	10.39	25884760
422	Phosphorylation	MINANAKTRGRIIDF HHHCCCCCCCCCCCH	35.63	-
436	Phosphorylation	FKEIQYGYRRVNPMY HHHHHHCCCCCCCCC	7.13	-
541	Phosphorylation	INILIPLSGRFDMFV EEEEEECCCCCHHHH	23.67	-
623	N-linked_Glycosylation	VGSSQFNNESLLFFC CCCCCCCCCCEEEEE	41.33	UniProtKB CARBOHYD
669	Phosphorylation	QYDPKIVYSGKVPSD CCCCEEEEECCCCCC	18.38	-
691	Phosphorylation	KTGFWRNYGFGITCI CCCCHHHCCEEEEEE	12.78	-
699	Phosphorylation	GFGITCIYKGDLVRV CEEEEEEEECCEEEE	15.86	-
769	O-linked_Glycosylation	MCLGSKASTYGSTQQ HHHCCHHHCCCCHHH	26.37	55832869
770	O-linked_Glycosylation	CLGSKASTYGSTQQL HHCCHHHCCCCHHHH	36.44	55832875
796	N-linked_Glycosylation	YSKSSNNNGSVRTA- CCCCCCCCCCCCCC-	48.65	UniProtKB CARBOHYD
798	Phosphorylation	KSSNNNGSVRTA--- CCCCCCCCCCCC---	15.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHSS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHSS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHSS1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CHSS1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 605282: Temtamy preaxial brachydactyly syndrome (TPBS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.