TX101_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TX101_HUMAN
• UniProt AC: Q9BY14
• Protein Name: Testis-expressed protein 101 {ECO:0000305}
• Gene Name: TEX101 {ECO:0000312|HGNC:HGNC:30722}
• Organism: Homo sapiens (Human).
• Sequence Length: 249
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor . Membrane raft . Cytoplasmic vesicle, secretory vesicle, acrosome . Secreted . Cytoplasmic vesicle . Located on plasma membrane of spermatocytes, round and elongated spermatids, and testicular spermatozoa.
• Protein Description: Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity)..
• Protein Sequence: MGTPRIQHLLILLVLGASLLTSGLELYCQKGLSMTVEADPANMFNWTTEEVETCDKGALCQETILIIKAGTETAILATKGCIPEGEEAITIVQHSSPPGLIVTSYSNYCEDSFCNDKDSLSQFWEFSETTASTVSTTLHCPTCVALGTCFSAPSLPCPNGTTRCYQGKLEITGGGIESSVEVKGCTAMIGCRLMSGILAVGPMFVREACPHQLLTQPRKTENGATCLPIPVWGLQLLLPLLLPSFIHFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13 (in isoform 2)	Phosphorylation	-	2.07	27762562
45	N-linked_Glycosylation	ADPANMFNWTTEEVE ECCCCCCCCCHHHHH	25.15	UniProtKB CARBOHYD
159	N-linked_Glycosylation	APSLPCPNGTTRCYQ CCCCCCCCCCCEEEE	68.13	UniProtKB CARBOHYD
178	Phosphorylation	ITGGGIESSVEVKGC EECCCCCCEEEECCC	37.45	30631047
179	Phosphorylation	TGGGIESSVEVKGCT ECCCCCCEEEECCCC	14.98	16964243
222	GPI-anchor	TQPRKTENGATCLPI CCCCCCCCCCCEEEC	51.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TX101_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TX101_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TX101_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UPAR_HUMAN	PLAUR	physical	19017363
UROK_HUMAN	PLAU	physical	19017363

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.