NDST2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDST2_HUMAN
• UniProt AC: P52849
• Protein Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
• Gene Name: NDST2
• Organism: Homo sapiens (Human).
• Sequence Length: 883
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan. [PubMed: 22660413]
• Protein Sequence: MLQLWKVVRPARQLELHRLILLLIAFSLGSMGFLAYYVSTSPKAKEPLPLPLGDCSSGGAAGPGPARPPVPPRPPRPPETARTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAPGRGDMPTLTDNTHGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAHEHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLLASLRPAEPAVPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLIFVDAVAYLTGKRLCLDLDRYILVDIDDIFVGKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRKEFWWFPHMWSHMQPHLFHNRSVLADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHTQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSRELDRSIRGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFESLVRFLQCWTRLRLQTLPPVPLAQKYFELFPQERSPLWQNPCDDKRHKDIWSKEKTCDRLPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQFFNSPNYHKGIDWYMDFFPVPSNASTDFLFEKSATYFDSEVVPRRGAALLPRAKIITVLTNPADRAYSWYQHQRAHGDPVALNYTFYQVISASSQTPLALRSLQNRCLVPGYYSTHLQRWLTYYPSGQLLIVDGQELRTNPAASMESIQKFLGITPFLNYTRTLRFDDDKGFWCQGLEGGKTRCLGRSKGRRYPDMDTESRLFLTDFFRNHNLELSKLLSRLGQPVPSWLREELQHSSLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
212	Phosphorylation	SAPLLHLTRPSRLEP CCCEEECCCCCCCCC	29.77	24719451
215	Phosphorylation	LLHLTRPSRLEPGPL EEECCCCCCCCCCCC	46.32	24719451
233	N-linked_Glycosylation	DWTIFQSNHSTYEPV CCEEEECCCCCCCCE	23.50	UniProtKB CARBOHYD
244	Phosphorylation	YEPVLLASLRPAEPA CCCEEEEECCCCCCC	25.53	24719451
350	N-linked_Glycosylation	KLRTLVPNFTFNLGF HHHHHCCCEEEEEEC	40.90	UniProtKB CARBOHYD
400	N-linked_Glycosylation	MQPHLFHNRSVLADQ CCHHHHCCHHHHHHH	30.50	UniProtKB CARBOHYD
553	Phosphorylation	VRFLQCWTRLRLQTL HHHHHHHHHHHHCCC	27.70	17081983
588	Acetylation	WQNPCDDKRHKDIWS CCCCCCCHHHHHHHH	43.05	20167786
591	Acetylation	PCDDKRHKDIWSKEK CCCCHHHHHHHHHHH	55.75	20167786
635	O-linked_Glycosylation	AVTSSFPSPSTFEEI CCCCCCCCCCCCCEE	29.49	OGP
666	N-linked_Glycosylation	DFFPVPSNASTDFLF EEECCCCCCCCCEEE	31.66	UniProtKB CARBOHYD
710	Phosphorylation	TNPADRAYSWYQHQR CCHHHHHHHHHHHHH	10.71	-
711	Phosphorylation	NPADRAYSWYQHQRA CHHHHHHHHHHHHHH	20.51	-
713	Phosphorylation	ADRAYSWYQHQRAHG HHHHHHHHHHHHHHC	7.09	-
726	N-linked_Glycosylation	HGDPVALNYTFYQVI HCCCEEEEEEEEEHH	24.86	UniProtKB CARBOHYD
802	N-linked_Glycosylation	LGITPFLNYTRTLRF HCCCCCCCCEEEEEC	36.19	UniProtKB CARBOHYD
843	Phosphorylation	YPDMDTESRLFLTDF CCCCCHHHHHHHHHH	36.05	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDST2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDST2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDST2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NDST2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.