dbPTM

PCSK5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PCSK5_HUMAN
UniProt AC	Q92824
Protein Name	Proprotein convertase subtilisin/kexin type 5
Gene Name	PCSK5
Organism	Homo sapiens (Human).
Sequence Length	1860
Subcellular Localization	Isoform PC6A: Secreted. Secreted through the regulated secretory pathway.. Isoform PC6B: Endomembrane system Single-pass type I membrane protein. Type I membrane protein localized to a paranuclear post-Golgi network compartment in communicatio
Protein Description	Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins..
Protein Sequence	MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDGEYVDEHGHCQTCEASCAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGADNYGREHFLYQGECGDSCPEGHYATEGNTCLPCPDNCELCHSVHVCTRCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYRFDHHCYKTCPEKTYSEEVECKACDSNCGSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECCDCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAGYEKLADPNKSYSSYKSSYRESTSFEEDQVIEYRDRDYDEDDDDDIVYMGQDGTVYRKFKYGLLDDDDIDELEYDDESYSYYQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Ubiquitination	EANRIASKYGFINIG HHHHHHHHHCCEEHH	40.13	21890473
56 (in isoform 2)	Ubiquitination	-	40.13	-
71	Phosphorylation	QIGALKDYYHFYHSR HHHHHHHHHEHHHHC	9.39	-
72	Phosphorylation	IGALKDYYHFYHSRT HHHHHHHHEHHHHCE	8.79	-
75	Phosphorylation	LKDYYHFYHSRTIKR HHHHHEHHHHCEEEE	5.88	-
83	Phosphorylation	HSRTIKRSVISSRGT HHCEEEEEHHCCCCC	20.85	26270265
86	Phosphorylation	TIKRSVISSRGTHSF EEEEEHHCCCCCCCE	16.30	26270265
87	Phosphorylation	IKRSVISSRGTHSFI EEEEHHCCCCCCCEE	24.49	24719451
116	Phosphorylation	KKRTKRDYDFSRAQS HHCCCCCCCCHHHHH	23.95	26657352
123	Phosphorylation	YDFSRAQSTYFNDPK CCCHHHHHHCCCCCC	24.88	26657352
124	Phosphorylation	DFSRAQSTYFNDPKW CCHHHHHHCCCCCCC	21.76	26657352
148	Phosphorylation	DNTHPCQSDMNIEGA CCCCCCCCCCCCCCH	45.61	-
185	Phosphorylation	HPDLMQNYDALASCD CHHHHHCCHHHHCCC	5.91	22210691
225	N-linked_Glycosylation	GEVAAAANNSHCTVG HHHHHHHCCCCCEEE	45.90	UniProtKB CARBOHYD
250	Phosphorylation	RMLDGDVTDMVEAKS EECCCCCCCEEEEEE	24.10	-
305	Phosphorylation	MGRRGLGSVFVWASG CCCCCCCCEEEEECC	19.88	-
353	Phosphorylation	WYLEECSSTLATTYS EEHHHHHCCEEEECC	38.81	-
381	N-linked_Glycosylation	LRQRCTDNHTGTSAS HHHHHCCCCCCCCCC	19.23	UniProtKB CARBOHYD
489	Phosphorylation	NSAVRSIYKASGCSD CHHHHHHHHHCCCCC	11.18	-
495	Phosphorylation	IYKASGCSDNPNRHV HHHHCCCCCCCCCCC	43.90	22210691
665	N-linked_Glycosylation	HYYYKLKNNTRICVS HHHHCCCCCCEEEEE	66.59	UniProtKB CARBOHYD
752	N-linked_Glycosylation	KTCTEFHNCTECRDG CCCHHHCCCCCCCCC	39.46	UniProtKB CARBOHYD
754	Phosphorylation	CTEFHNCTECRDGLS CHHHCCCCCCCCCEE	43.36	-
802	N-linked_Glycosylation	AGADGCINCTEGYFM CCCCCCEECCCCEEC	30.63	UniProtKB CARBOHYD
852	N-linked_Glycosylation	CNGPGFKNCTSCPSG CCCCCCCCCCCCCCC	31.85	UniProtKB CARBOHYD
1014	N-linked_Glycosylation	GYFIAPTNHTCQKLE CEEEECCCCCCCEEC	27.67	UniProtKB CARBOHYD
1191	N-linked_Glycosylation	HSSCKTCNGSATLCT CCCCCCCCCCCEECC	53.32	UniProtKB CARBOHYD
1263	Phosphorylation	FLHEGRCYSKCPEGS EEECCEEECCCCCCC	15.14	-
1264	Phosphorylation	LHEGRCYSKCPEGSY EECCEEECCCCCCCC	31.26	-
1270	Phosphorylation	YSKCPEGSYAEDGIC ECCCCCCCCCCCCCC	21.36	-
1271	Phosphorylation	SKCPEGSYAEDGICE CCCCCCCCCCCCCCC	25.52	-
1290	N-linked_Glycosylation	PCRTCEGNATNCHSC CCCCCCCCCCCCCCC	22.69	UniProtKB CARBOHYD
1424	Phosphorylation	ECRDCHKSCLTCSSS CCCCCCCHHCEECCC	7.24	-
1427	Phosphorylation	DCHKSCLTCSSSGTC CCCCHHCEECCCCCC	18.05	30576142
1430	Phosphorylation	KSCLTCSSSGTCTTC CHHCEECCCCCCCCC	34.63	30576142
1435	Phosphorylation	CSSSGTCTTCQKGLI ECCCCCCCCCCCCEE	30.37	30576142
1436	Phosphorylation	SSSGTCTTCQKGLIM CCCCCCCCCCCCEEE	18.32	-
1497	N-linked_Glycosylation	PMNSLLLNTTCVKDC CCCCEEECCEEECCC	33.06	UniProtKB CARBOHYD
1572	Phosphorylation	RCERCNRSCKGCQGP CCCCCCCCCCCCCCC	13.24	-
1596	Phosphorylation	RFFFLLRSKGECHRS CEEEEEECCCCHHCC	45.01	27251275
1685	N-linked_Glycosylation	CKGPGAKNCTLCPAN CCCCCCCCCEECCCE	24.38	UniProtKB CARBOHYD
1707	N-linked_Glycosylation	SHCLHCCNTSDPPSA CCCCCCCCCCCCCCH	48.27	UniProtKB CARBOHYD
1743	Phosphorylation	PATEHFKTALFITSS CCCHHHHHHHHHHHH	27.87	24043423
1748	Phosphorylation	FKTALFITSSMMLVL HHHHHHHHHHHHHHH	13.86	24043423
1749	Phosphorylation	KTALFITSSMMLVLL HHHHHHHHHHHHHHH	16.06	24043423
1750	Phosphorylation	TALFITSSMMLVLLL HHHHHHHHHHHHHHH	10.28	24043423
1788	Phosphorylation	KLADPNKSYSSYKSS HHCCCCCCHHHCCCC	36.57	30576142
1789	Phosphorylation	LADPNKSYSSYKSSY HCCCCCCHHHCCCCC	11.84	30576142
1790	Phosphorylation	ADPNKSYSSYKSSYR CCCCCCHHHCCCCCC	33.99	30576142
1799	Phosphorylation	YKSSYRESTSFEEDQ CCCCCCCCCCCCCCC	21.98	28857561
1800	Phosphorylation	KSSYRESTSFEEDQV CCCCCCCCCCCCCCE	32.45	28857561
1801	Phosphorylation	SSYRESTSFEEDQVI CCCCCCCCCCCCCEE	39.68	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PCSK5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PCSK5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PCSK5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBP2_HUMAN	APPBP2	physical	16189514
ENV_HV1H2	env	physical	8940009
STK16_HUMAN	STK16	physical	25416956
GLRX3_HUMAN	GLRX3	physical	25416956
NUFP2_HUMAN	NUFIP2	physical	25416956
KR412_HUMAN	KRTAP4-12	physical	25416956
LCE3C_HUMAN	LCE3C	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PCSK5_HUMAN

Related Literatures of Post-Translational Modification