HXD13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXD13_HUMAN
• UniProt AC: P35453
• Protein Name: Homeobox protein Hox-D13
• Gene Name: HOXD13
• Organism: Homo sapiens (Human).
• Sequence Length: 343
• Subcellular Localization: Nucleus .
• Protein Description: Sequence-specific transcription factor that binds gene promoters and activates their transcription. [PubMed: 24789103 Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity]
• Protein Sequence: MSRAGSWDMDGLRADGGGAGGAPASSSSSSVAAAAASGQCRGFLSAPVFAGTHSGRAAAAAAAAAAAAAAASGFAYPGTSERTGSSSSSSSSAVVAARPEAPPAKECPAPTPAAAAAAPPSAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDVSGLASSSVPANEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANGWNSQVYCTKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSRAGSWDMDGLR --CCCCCCCCCCCCC	20.93	22210691
29	Phosphorylation	APASSSSSSVAAAAA CCCCCCHHHHHHHHH	30.68	22210691
83	Phosphorylation	YPGTSERTGSSSSSS CCCCCCCCCCCCCCC	37.05	27251275
85	Phosphorylation	GTSERTGSSSSSSSS CCCCCCCCCCCCCCE	26.83	27251275
86	Phosphorylation	TSERTGSSSSSSSSA CCCCCCCCCCCCCEE	35.27	27251275
87	Phosphorylation	SERTGSSSSSSSSAV CCCCCCCCCCCCEEE	35.62	27251275
88	Phosphorylation	ERTGSSSSSSSSAVV CCCCCCCCCCCEEEE	35.87	27251275
89	Phosphorylation	RTGSSSSSSSSAVVA CCCCCCCCCCEEEEE	35.87	27251275
90	Phosphorylation	TGSSSSSSSSAVVAA CCCCCCCCCEEEEEE	30.20	27251275
91	Phosphorylation	GSSSSSSSSAVVAAR CCCCCCCCEEEEEEC	25.02	27251275
92	Phosphorylation	SSSSSSSSAVVAARP CCCCCCCEEEEEECC	27.34	27251275
127	Phosphorylation	PSAPALGYGYHFGNG CCCCCCCCCCCCCCC	18.50	-
153	Phosphorylation	LQQNALKSSPHASLG CCCHHHHCCCCCHHC	50.37	30377224
154	Phosphorylation	QQNALKSSPHASLGG CCHHHHCCCCCHHCC	21.08	30377224
158	Phosphorylation	LKSSPHASLGGFPVE HHCCCCCHHCCCCCH	25.23	23312004
266	Ubiquitination	FPGDVALNQPDMCVY CCCCCCCCCCCEEEE	41.42	22817900
270	Ubiquitination	VALNQPDMCVYRRGR CCCCCCCEEEEECCC	1.80	21890473
285	Ubiquitination	KKRVPYTKLQLKELE CCCCCCCHHCHHHHH	28.52	22817900
289	Ubiquitination	PYTKLQLKELENEYA CCCHHCHHHHHHHHH	47.49	22817900
313	Phosphorylation	RRRISAATNLSERQV HHHHHHCCCCCHHHE	36.09	-
316	Phosphorylation	ISAATNLSERQVTIW HHHCCCCCHHHEEEE	32.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXD13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXD13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXD13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HAND2_HUMAN	HAND2	physical	20386744

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 186000: Synpolydactyly 1 (SPD1)
• 113200: Brachydactyly D (BDD)
• 186300: Syndactyly 5 (SDTY5)
• 610713: Brachydactyly-syndactyly syndrome (BDSD)
• 113300: Brachydactyly E1 (BDE1)
• 192350: VACTERL association (VACTERL)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.