HAND2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HAND2_HUMAN
• UniProt AC: P61296
• Protein Name: Heart- and neural crest derivatives-expressed protein 2
• Gene Name: HAND2
• Organism: Homo sapiens (Human).
• Sequence Length: 217
• Subcellular Localization: Nucleus .
• Protein Description: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity)..
• Protein Sequence: MSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFHGWLIGHPEMSPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQHVWALELKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	Phosphorylation	NRKERRRTQSINSAF CHHHHHHHHHHHHHH	25.51	27732954
114	Phosphorylation	KERRRTQSINSAFAE HHHHHHHHHHHHHHH	24.11	25884760
117	Phosphorylation	RRTQSINSAFAELRE HHHHHHHHHHHHHHH	24.08	27732954
152	Ubiquitination	TSYIAYLMDLLAKDD HHHHHHHHHHHHCCC	1.91	21890473
177	Acetylation	EIKKTDVKEEKRKKE HHHHCCCCHHHHHHH	64.07	7430971
177	Ubiquitination	EIKKTDVKEEKRKKE HHHHCCCCHHHHHHH	64.07	23000965
180	Acetylation	KTDVKEEKRKKELNE HCCCCHHHHHHHHHH	71.28	7430981
180	Ubiquitination	KTDVKEEKRKKELNE HCCCCHHHHHHHHHH	71.28	23000965
182	Acetylation	DVKEEKRKKELNEIL CCCHHHHHHHHHHHH	62.76	7430991
182	Ubiquitination	DVKEEKRKKELNEIL CCCHHHHHHHHHHHH	62.76	23000965
183	Ubiquitination	VKEEKRKKELNEILK CCHHHHHHHHHHHHH	72.04	21890473
183	Acetylation	VKEEKRKKELNEILK CCHHHHHHHHHHHHH	72.04	25953088
183	Ubiquitination	VKEEKRKKELNEILK CCHHHHHHHHHHHHH	72.04	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HAND2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HAND2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HAND2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CENPB_HUMAN	CENPB	physical	11812799
CSN5_HUMAN	COPS5	physical	11812799
2A5D_HUMAN	PPP2R5D	physical	14636580
PHX2A_HUMAN	PHOX2A	physical	14506227
EP300_HUMAN	EP300	physical	11994297
NPM_HUMAN	NPM1	physical	11812799
HAND2_HUMAN	HAND2	physical	11812799
HXD13_HUMAN	HOXD13	physical	20386744

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.