PHX2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHX2A_HUMAN
• UniProt AC: O14813
• Protein Name: Paired mesoderm homeobox protein 2A
• Gene Name: PHOX2A
• Organism: Homo sapiens (Human).
• Sequence Length: 284
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype..
• Protein Sequence: MDYSYLNSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGAAGAKKGEARCSSEDDDSKESTCSPTPDSTASLPPPPAPGLASPRLSPSPLPVALGSGPGPGPGPQPLKGALWAGVAGGGGGGPGAGAAELLKAWQPAESGPGPFSGVLSSFHRKPGPALKTNLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	PPCPALGSSNCALGA CCCCCCCCCCCHHHH	21.16	27732954
55	Phosphorylation	PCPALGSSNCALGAL CCCCCCCCCCHHHHH	33.84	27732954
76	Ubiquitination	PYSAVPYKFFPEPSG CCCCCCCCCCCCCCC	34.16	23503661
87	Ubiquitination	EPSGLHEKRKQRRIR CCCCHHHHHHHHHHH	54.90	23503661
89	Ubiquitination	SGLHEKRKQRRIRTT CCHHHHHHHHHHHHH	60.26	23503661
103	Ubiquitination	TFTSAQLKELERVFA HHCHHHHHHHHHHHH	48.44	23503661
153	Phosphorylation	RKQERAASAKGAAGA HHHHHHHHHHHHHHH	29.54	22817900
155	Acetylation	QERAASAKGAAGAAG HHHHHHHHHHHHHHH	46.73	12436251
155	Ubiquitination	QERAASAKGAAGAAG HHHHHHHHHHHHHHH	46.73	23503661
171	Phosphorylation	KKGEARCSSEDDDSK CCCCCCCCCCCCCCC	31.07	30177828
172	Phosphorylation	KGEARCSSEDDDSKE CCCCCCCCCCCCCCC	48.98	30177828
180	Phosphorylation	EDDDSKESTCSPTPD CCCCCCCCCCCCCCC	38.15	27732954
181	Phosphorylation	DDDSKESTCSPTPDS CCCCCCCCCCCCCCC	20.35	27732954
183	Phosphorylation	DSKESTCSPTPDSTA CCCCCCCCCCCCCCC	31.71	27732954
185	Phosphorylation	KESTCSPTPDSTASL CCCCCCCCCCCCCCC	24.35	27732954
188	Phosphorylation	TCSPTPDSTASLPPP CCCCCCCCCCCCCCC	27.38	27732954
189	Phosphorylation	CSPTPDSTASLPPPP CCCCCCCCCCCCCCC	27.87	27732954
191	Phosphorylation	PTPDSTASLPPPPAP CCCCCCCCCCCCCCC	41.31	27732954
202	Phosphorylation	PPAPGLASPRLSPSP CCCCCCCCCCCCCCC	18.65	27732954
206	Phosphorylation	GLASPRLSPSPLPVA CCCCCCCCCCCCCCC	25.31	29900121
208	Phosphorylation	ASPRLSPSPLPVALG CCCCCCCCCCCCCCC	35.38	24117733
216	Phosphorylation	PLPVALGSGPGPGPG CCCCCCCCCCCCCCC	42.54	27732954
269	Phosphorylation	GPFSGVLSSFHRKPG CCCCCHHHHHCCCCC	28.66	24117733
270	Phosphorylation	PFSGVLSSFHRKPGP CCCCHHHHHCCCCCC	22.40	24117733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
153	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHX2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHX2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HAND2_HUMAN	HAND2	physical	14506227
JUN_HUMAN	JUN	physical	14506227
PHX2A_HUMAN	PHOX2A	physical	10644760
SP1_HUMAN	SP1	physical	17344216

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 602078: Fibrosis of extraocular muscles, congenital, 2 (CFEOM2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.