| UniProt ID | BMP8B_HUMAN | |
|---|---|---|
| UniProt AC | P34820 | |
| Protein Name | Bone morphogenetic protein 8B | |
| Gene Name | BMP8B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 402 | |
| Subcellular Localization | Secreted. | |
| Protein Description | Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).. | |
| Protein Sequence | MTALPGPLWLLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 158 | N-linked_Glycosylation | VPSIHLLNRTLHVSM CCCHHHHCCEEEEEH | 41.05 | UniProtKB CARBOHYD | |
| 186 | Phosphorylation | LFFLDLQTLRAGDEG EEEEECCCEECCCCC | 26.05 | - | |
| 209 | Ubiquitination | ASDCWLLKRHKDLGL CCCEEEHHHCCCCCC | 50.73 | - | |
| 212 | Ubiquitination | CWLLKRHKDLGLRLY EEEHHHCCCCCCEEE | 59.69 | 29967540 | |
| 255 | Phosphorylation | VVTFFRASPSPIRTP EEEEEECCCCCCCCC | 22.96 | 24719451 | |
| 257 | Phosphorylation | TFFRASPSPIRTPRA EEEECCCCCCCCCCC | 30.39 | 26546556 | |
| 343 | N-linked_Glycosylation | FPLDSCMNATNHAIL CCHHHHCHHHCHHHH | 48.19 | UniProtKB CARBOHYD | |
| 375 | Phosphorylation | APTKLSATSVLYYDS CCCCCCCCEEEEEEC | 18.91 | 24114839 | |
| 376 | Phosphorylation | PTKLSATSVLYYDSS CCCCCCCEEEEEECC | 15.16 | 24114839 | |
| 379 | Phosphorylation | LSATSVLYYDSSNNV CCCCEEEEEECCCCE | 11.76 | 24114839 | |
| 380 | Phosphorylation | SATSVLYYDSSNNVI CCCEEEEEECCCCEE | 12.75 | 24114839 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BMP8B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BMP8B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BMP8B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of BMP8B_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
