MGT4B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MGT4B_HUMAN
• UniProt AC: Q9UQ53
• Protein Name: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
• Gene Name: MGAT4B
• Organism: Homo sapiens (Human).
• Sequence Length: 548
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis..
• Protein Sequence: MRLRNGTFLTLLLFCLCAFLSLSWYAALSGQKGDVVDVYQREFLALRDRLHAAEQESLKRSKELNLVLDEIKRAVSERQALRDGDGNRTWGRLTEDPRLKPWNGSHRHVLHLPTVFHHLPHLLAKESSLQPAVRVGQGRTGVSVVMGIPSVRREVHSYLTDTLHSLISELSPQEKEDSVIVVLIAETDSQYTSAVTENIKALFPTEIHSGLLEVISPSPHFYPDFSRLRESFGDPKERVRWRTKQNLDYCFLMMYAQSKGIYYVQLEDDIVAKPNYLSTMKNFALQQPSEDWMILEFSQLGFIGKMFKSLDLSLIVEFILMFYRDKPIDWLLDHILWVKVCNPEKDAKHCDRQKANLRIRFKPSLFQHVGTHSSLAGKIQKLKDKDFGKQALRKEHVNPPAEVSTSLKTYQHFTLEKAYLREDFFWAFTPAAGDFIRFRFFQPLRLERFFFRSGNIEHPEDKLFNTSVEVLPFDNPQSDKEALQEGRTATLRYPRSPDGYLQIGSFYKGVAEGEVDPAFGPLEALRLSIQTDSPVWVILSEIFLKKAD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Dimethylation	MRLRNGTFLTLLLFC CCCCCHHHHHHHHHH	5.34	-
17	Dimethylation	TLLLFCLCAFLSLSW HHHHHHHHHHHHHHH	2.37	-
59 (in isoform 2)	Ubiquitination	-	65.00	21906983
59	Ubiquitination	AAEQESLKRSKELNL HHHHHHHHHHHHHHH	65.00	21906983
59 (in isoform 1)	Ubiquitination	-	65.00	21906983
62	Ubiquitination	QESLKRSKELNLVLD HHHHHHHHHHHHHHH	70.97	29967540
72	Ubiquitination	NLVLDEIKRAVSERQ HHHHHHHHHHHHHHH	32.05	29967540
77	Ubiquitination	EIKRAVSERQALRDG HHHHHHHHHHHHHCC	42.06	29967540
87	N-linked_Glycosylation	ALRDGDGNRTWGRLT HHHCCCCCCCCCCCC	42.84	UniProtKB CARBOHYD
87	Ubiquitination	ALRDGDGNRTWGRLT HHHCCCCCCCCCCCC	42.84	29967540
103	N-linked_Glycosylation	DPRLKPWNGSHRHVL CCCCCCCCCCCCCEE	51.09	UniProtKB CARBOHYD
140	Phosphorylation	VRVGQGRTGVSVVMG EECCCCCCCCEEEEC	49.08	24043423
143	Phosphorylation	GQGRTGVSVVMGIPS CCCCCCCEEEECCHH	15.44	30257219
150	Phosphorylation	SVVMGIPSVRREVHS EEEECCHHHHHHHHH	26.74	24043423
187	Phosphorylation	IVVLIAETDSQYTSA EEEEEEECCCHHHHH	31.74	-
191	Phosphorylation	IAETDSQYTSAVTEN EEECCCHHHHHHHHH	13.45	-
216	Phosphorylation	SGLLEVISPSPHFYP CCCEEHHCCCCCCCC	25.22	-
262	Phosphorylation	YAQSKGIYYVQLEDD HHHHCCEEEEEECCC	13.27	29083192
263	Phosphorylation	AQSKGIYYVQLEDDI HHHCCEEEEEECCCC	4.64	23532336
276	Phosphorylation	DIVAKPNYLSTMKNF CCEECCCHHHHHCCH	15.57	29083192
278	Phosphorylation	VAKPNYLSTMKNFAL EECCCHHHHHCCHHC	18.98	29083192
279	Phosphorylation	AKPNYLSTMKNFALQ ECCCHHHHHCCHHCC	29.57	23532336
364	Phosphorylation	LRIRFKPSLFQHVGT HEEEECHHHHHHCCC	42.26	30622161
371	Phosphorylation	SLFQHVGTHSSLAGK HHHHHCCCCHHHHHH	19.93	30622161
373	Phosphorylation	FQHVGTHSSLAGKIQ HHHCCCCHHHHHHHH	27.21	30622161
374	Phosphorylation	QHVGTHSSLAGKIQK HHCCCCHHHHHHHHH	18.03	30622161
389	Ubiquitination	LKDKDFGKQALRKEH HCCCCHHHHHHHHHC	32.18	29967540
394	Ubiquitination	FGKQALRKEHVNPPA HHHHHHHHHCCCCCH	53.69	29967540
404	Ubiquitination	VNPPAEVSTSLKTYQ CCCCHHHCHHHCCCC	12.09	29967540
404	Phosphorylation	VNPPAEVSTSLKTYQ CCCCHHHCHHHCCCC	12.09	21214269
405	Phosphorylation	NPPAEVSTSLKTYQH CCCHHHCHHHCCCCC	43.16	21214269
409	Ubiquitination	EVSTSLKTYQHFTLE HHCHHHCCCCCEEEC	33.44	29967540
410	Phosphorylation	VSTSLKTYQHFTLEK HCHHHCCCCCEEECH	9.82	21214269
419	Phosphorylation	HFTLEKAYLREDFFW CEEECHHHCCCCEEE	19.84	-
479 (in isoform 2)	Ubiquitination	-	47.79	21906983
480	Ubiquitination	FDNPQSDKEALQEGR CCCCCCHHHHHHCCC	50.57	21906983
480 (in isoform 1)	Ubiquitination	-	50.57	21906983
490	O-linked_Glycosylation	LQEGRTATLRYPRSP HHCCCCEEECCCCCC	15.91	57782045

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MGT4B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MGT4B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MGT4B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYJ2B_HUMAN	SYNJ2BP	physical	22939629
UCRI_HUMAN	UQCRFS1	physical	22939629
S26A2_HUMAN	SLC26A2	physical	22939629
SFXN2_HUMAN	SFXN2	physical	22939629
VDAC1_HUMAN	VDAC1	physical	22939629
HBB_HUMAN	HBB	physical	26186194
HBB_HUMAN	HBB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.