SFXN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SFXN2_HUMAN
• UniProt AC: Q96NB2
• Protein Name: Sideroflexin-2
• Gene Name: SFXN2
• Organism: Homo sapiens (Human).
• Sequence Length: 322
• Subcellular Localization: Mitochondrion membrane; Multi-pass membrane protein.
• Protein Description: Potential iron transporter..
• Protein Sequence: MEADLSGFNIDAPRWDQRTFLGRVKHFLNITDPRTVFVSERELDWAKVMVEKSRMGVVPPGTQVEQLLYAKKLYDSAFHPDTGEKMNVIGRMSFQLPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMALSYFTATTTAVATAVGMNMLTKKAPPLVGRWVPFAAVAAANCVNIPMMRQQELIKGICVKDRNENEIGHSRRAAAIGITQVVISRITMSAPGMILLPVIMERLEKLHFMQKVKVLHAPLQVMLSGCFLIFMVPVACGLFPQKCELPVSYLEPKLQDTIKAKYGELEPYVYFNKGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEADLSGF -------CCCCCCCC	9.63	22814378
25	Ubiquitination	RTFLGRVKHFLNITD HHHHHHHHHHHCCCC	27.55	21890473
25	Ubiquitination	RTFLGRVKHFLNITD HHHHHHHHHHHCCCC	27.55	21890473
47	Ubiquitination	ERELDWAKVMVEKSR HHHCHHHHHHHHHHH	26.98	-
71	Ubiquitination	VEQLLYAKKLYDSAF HHHHHHHHHHHHCCC	29.74	-
72	Ubiquitination	EQLLYAKKLYDSAFH HHHHHHHHHHHCCCC	44.07	-
139	Phosphorylation	YTNRNAASPTSVRQM CCCCCCCCCHHHHHH	26.71	28857561
141	Phosphorylation	NRNAASPTSVRQMAL CCCCCCCHHHHHHHH	37.04	28857561
149	Phosphorylation	SVRQMALSYFTATTT HHHHHHHHHHHHHHH	14.52	21214269
150	Phosphorylation	VRQMALSYFTATTTA HHHHHHHHHHHHHHH	13.05	23401153
152	Phosphorylation	QMALSYFTATTTAVA HHHHHHHHHHHHHHH	18.18	23401153
154	Phosphorylation	ALSYFTATTTAVATA HHHHHHHHHHHHHHH	22.94	23401153
155	Phosphorylation	LSYFTATTTAVATAV HHHHHHHHHHHHHHH	15.42	22210691
156	Phosphorylation	SYFTATTTAVATAVG HHHHHHHHHHHHHHH	18.12	22210691
160	Phosphorylation	ATTTAVATAVGMNML HHHHHHHHHHHHHHH	18.44	24043423
168	Phosphorylation	AVGMNMLTKKAPPLV HHHHHHHCCCCCCCC	21.52	23401153
202	Ubiquitination	MRQQELIKGICVKDR CCCHHHHCCCEECCC	55.64	-
226	Phosphorylation	RAAAIGITQVVISRI HHHHHCCCHHHHHCC	15.31	-
231	Phosphorylation	GITQVVISRITMSAP CCCHHHHHCCCCCCC	13.16	-
234	Phosphorylation	QVVISRITMSAPGMI HHHHHCCCCCCCCHH	12.17	25348772
236	Phosphorylation	VISRITMSAPGMILL HHHCCCCCCCCHHHH	23.74	22210691
300	Ubiquitination	PVSYLEPKLQDTIKA CHHHCCHHHHHHHHH	49.78	-
308	Ubiquitination	LQDTIKAKYGELEPY HHHHHHHHHCCCCCE	49.11	21890473
308	Ubiquitination	LQDTIKAKYGELEPY HHHHHHHHHCCCCCE	49.11	21890473
320	Ubiquitination	EPYVYFNKGL----- CCEEEECCCC-----	52.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SFXN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SFXN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SFXN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOM70_HUMAN	TOMM70A	physical	22939629
SPG7_HUMAN	SPG7	physical	22939629
TOM7_HUMAN	TOMM7	physical	22939629
CDK18_HUMAN	CDK18	physical	26186194
SNX2_HUMAN	SNX2	physical	26186194
CDK18_HUMAN	CDK18	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.