FAKD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAKD3_HUMAN
• UniProt AC: Q14CZ7
• Protein Name: FAST kinase domain-containing protein 3, mitochondrial
• Gene Name: FASTKD3
• Organism: Homo sapiens (Human).
• Sequence Length: 662
• Subcellular Localization: Mitochondrion .
• Protein Description: Required for normal mitochondrial respiration. [PubMed: 20869947 Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity]
• Protein Sequence: MALITLRKNLYRLSDFQMHRALAALKNKPLNHVHKVVKERLCPWLCSRQPEPFGVKFHHAHCKKFHSKNGNDLHPLGGPVFSQVSDCDRLEQNVKNEESQMFYRRLSNLTSSEEVLSFISTMETLPDTMAAGALQRICEVEKKDGDQGLPKEILENSIFQALCFQFEKEPSQLSNTSLVTALQALILLHVDPQSSLLLNLVAECQNRLRKGGMEVRNLCILGESLITLHSSGCVTLELIINQLQGEKLETFTPEDIVALYRILQACTEKVDEHQTFLNKINNFSLSIVSNLSPKLISQMLTALVVLDQSQAFPLIIKLGKYVVRHVPHFTNEELRRVLEAFIYFGHHDTFFTKALEHRVAAVCLTLDPEVVCRVMEYCSRELILSKPILNAVAETFVCQTEKFSPRQISALMEPFGKLNYLPPNASALFRKLENVLFTHFNYFPPKSLLKLLHSCSLNECHPVNFLAKIFKPLFLQRLQGKESHLDTLSRAQLTQLFLASVLECPFYKGPKLLPKYQVKSFLTPCCSLETPVDSQLYRYVKIGLTNLLGARLYFAPKVLTPYCYTIDVEIKLDEEGFVLPSTANEDIHKRIALCIDGPKRFCSNSKHLLGKEAIKQRHLQLLGYQVVQIPYHEIGMLKSRRELVEYLQRKLFSQNTVHWLQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Phosphorylation	QNVKNEESQMFYRRL HHCCHHHHHHHHHHH	22.29	29978859
103	Phosphorylation	NEESQMFYRRLSNLT HHHHHHHHHHHHCCC	6.89	29978859
252	Phosphorylation	GEKLETFTPEDIVAL CCCCCCCCHHHHHHH	32.94	22817900
269	Ubiquitination	ILQACTEKVDEHQTF HHHHHHCCCHHHHHH	36.51	29967540
309	Phosphorylation	ALVVLDQSQAFPLII HHHHHCHHHCHHHHH	24.12	-
330	Phosphorylation	VRHVPHFTNEELRRV HHHCCCCCHHHHHHH	38.39	-
447	Phosphorylation	FNYFPPKSLLKLLHS CCCCCCHHHHHHHHH	44.71	24719451
471	Succinylation	NFLAKIFKPLFLQRL HHHHHHHHHHHHHHH	44.26	23954790
481	Malonylation	FLQRLQGKESHLDTL HHHHHCCCCCHHHHC	42.98	32601280
483	Phosphorylation	QRLQGKESHLDTLSR HHHCCCCCHHHHCCH	32.60	-
519	Ubiquitination	LLPKYQVKSFLTPCC CCCHHCCCCCCCCCC	21.69	-
589	Ubiquitination	TANEDIHKRIALCID CCCCCHHHHHHHHCC	45.92	29967540
611	Ubiquitination	NSKHLLGKEAIKQRH CCHHHCCHHHHHHHH	43.89	29967540
624	Phosphorylation	RHLQLLGYQVVQIPY HHHHHHCCEEEECCH	9.71	19605366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAKD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAKD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAKD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAM9B_HUMAN	FAM9B	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.