TXD16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXD16_HUMAN
• UniProt AC: Q9P2K2
• Protein Name: Thioredoxin domain-containing protein 16 {ECO:0000312|HGNC:HGNC:19965}
• Gene Name: TXNDC16 {ECO:0000312|HGNC:HGNC:19965}
• Organism: Homo sapiens (Human).
• Sequence Length: 825
• Subcellular Localization: Secreted . Endoplasmic reticulum lumen .
• Protein Sequence: MFSGFNVFRVGISFVIMCIFYMPTVNSLPELSPQKYFSTLQPGKASLAYFCQADSPRTSVFLEELNEAVRPLQDYGISVAKVNCVKEEISRYCGKEKDLMKAYLFKGNILLREFPTDTLFDVNAIVAHVLFALLFSEVKYITNLEDLQNIENALKGKANIIFSYVRAIGIPEHRAVMEAAFVYGTTYQFVLTTEIALLESIGSEDVEYAHLYFFHCKLVLDLTQQCRRTLMEQPLTTLNIHLFIKTMKAPLLTEVAEDPQQVSTVHLQLGLPLVFIVSQQATYEADRRTAEWVAWRLLGKAGVLLLLRDSLEVNIPQDANVVFKRAEEGVPVEFLVLHDVDLIISHVENNMHIEEIQEDEDNDMEGPDIDVQDDEVAETVFRDRKRKLPLELTVELTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCADWSDVCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFIQLNRISYPVNITSIQEAEEYLSGELYKDLILYSSVSVLGLFSPTMKTAKEDFSEAGNYLKGYVITGIYSEEDVLLLSTKYAASLPALLLARHTEGKIESIPLASTHAQDIVQIITDALLEMFPEITVENLPSYFRLQKPLLILFSDGTVNPQYKKAILTLVKQKYLDSFTPCWLNLKNTPVGRGILRAYFDPLPPLPLLVLVNLHSGGQVFAFPSDQAIIEENLVLWLKKLEAGLENHITILPAQEWKPPLPAYDFLSMIDAATSQRGTRKVPKCMKETDVQENDKEQHEDKSAVRKEPIETLRIKHWNRSNWFKEAEKSFRRDKELGCSKVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	NVFRVGISFVIMCIF CEECCHHCHHHHHHH	13.92	25002506
21	Phosphorylation	FVIMCIFYMPTVNSL HHHHHHHHCCCCCCC	5.14	25002506
24	Phosphorylation	MCIFYMPTVNSLPEL HHHHHCCCCCCCCCC	18.78	25002506
27	Phosphorylation	FYMPTVNSLPELSPQ HHCCCCCCCCCCCHH	40.75	25002506
32	Phosphorylation	VNSLPELSPQKYFST CCCCCCCCHHHCCCC	24.51	25002506
75	Phosphorylation	AVRPLQDYGISVAKV HHHHHHHCCCCEEEH	11.91	-
78	Phosphorylation	PLQDYGISVAKVNCV HHHHCCCCEEEHHHH	16.20	-
86	Ubiquitination	VAKVNCVKEEISRYC EEEHHHHHHHHHHHC	52.40	-
229	Phosphorylation	LTQQCRRTLMEQPLT HHHHHHHHHHHCCCC	15.88	22964224
236	Phosphorylation	TLMEQPLTTLNIHLF HHHHCCCCCEEHHHH	35.60	22964224
237	Phosphorylation	LMEQPLTTLNIHLFI HHHCCCCCEEHHHHH	26.03	22964224
246	Phosphorylation	NIHLFIKTMKAPLLT EHHHHHHHCCCCCHH	21.06	22964224
440	Phosphorylation	AVKLKGTSTMLLTRI HHHCCCCCEEEEEEC	22.08	22210691
441	Phosphorylation	VKLKGTSTMLLTRIN HHCCCCCEEEEEECC	16.21	22210691
445	Phosphorylation	GTSTMLLTRINCADW CCCEEEEEECCCCCH	26.07	22210691
460	N-linked_Glycosylation	SDVCTKQNVTEFPII HHHCCCCCCCCCCEE	44.21	UniProtKB CARBOHYD
524	Phosphorylation	LYKDLILYSSVSVLG HHHHHHHHHHHHHHH	7.60	-
541	Ubiquitination	SPTMKTAKEDFSEAG CCCCHHHHHHHHHHH	64.15	-
569	Phosphorylation	EEDVLLLSTKYAASL HHHHHHHCHHHHHHH	23.87	24719451
572	Phosphorylation	VLLLSTKYAASLPAL HHHHCHHHHHHHHHH	13.90	-
575	Phosphorylation	LSTKYAASLPALLLA HCHHHHHHHHHHHHH	27.06	-
794	Phosphorylation	VRKEPIETLRIKHWN HCCCCCHHHHCCCCC	23.27	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TXD16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXD16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXD16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FLNA_HUMAN	FLNA	physical	22119785
RL35_HUMAN	RPL35	physical	22119785
PPIB_HUMAN	PPIB	physical	22119785
ENOA_HUMAN	ENO1	physical	22119785
HNRPU_HUMAN	HNRNPU	physical	22119785
ROA2_HUMAN	HNRNPA2B1	physical	22119785
AT5F1_HUMAN	ATP5F1	physical	22119785
MCM2_HUMAN	MCM2	physical	22119785
TAGL2_HUMAN	TAGLN2	physical	22119785
FXRD2_HUMAN	FOXRED2	physical	22119785
MARCS_HUMAN	MARCKS	physical	22119785

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.