LOXL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LOXL2_HUMAN
• UniProt AC: Q9Y4K0
• Protein Name: Lysyl oxidase homolog 2
• Gene Name: LOXL2
• Organism: Homo sapiens (Human).
• Sequence Length: 774
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane . Nucleus . Chromosome . Endoplasmic reticulum . Associated with chromatin (PubMed:27735137). It is unclear how LOXL2 is nuclear as it contains a signal sequence and has been show
• Protein Description: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). [PubMed: 27735137 Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation]
• Protein Sequence: MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRLAGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGPIWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLNIQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGERTYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVSCVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDAGVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAGVACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLEDTECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEVAESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
146	Phosphorylation	TSNGWGVTDCKHTED CCCCCCCCCCCCCCC	31.57	-
161	Ubiquitination	VGVVCSDKRIPGFKF EEEEECCCCCCCCCC	35.61	29967540
161	2-Hydroxyisobutyrylation	VGVVCSDKRIPGFKF EEEEECCCCCCCCCC	35.61	-
197	Acetylation	AILSTYRKRTPVMEG HHHHHHHCCCCCEEE	50.65	20167786
209	Acetylation	MEGYVEVKEGKTWKQ EEECEEEECCCCHHH	47.44	20167786
220	Ubiquitination	TWKQICDKHWTAKNS CHHHHHHHHCCCCCC	36.31	29967540
225	Acetylation	CDKHWTAKNSRVVCG HHHHCCCCCCCEEEE	48.34	20167786
244	Phosphorylation	PGERTYNTKVYKMFA CCCCCCCHHHHHHHH	16.09	28509920
248	Acetylation	TYNTKVYKMFASRRK CCCHHHHHHHHHHCC	30.45	7663231
288	N-linked_Glycosylation	VSLDPMKNVTCENGL CCCCCCCCCEECCCC	28.25	UniProtKB CARBOHYD
317	Ubiquitination	DGPSRFRKAYKPEQP CCCCHHHHHCCCCCC	54.05	29967540
320	Ubiquitination	SRFRKAYKPEQPLVR CHHHHHCCCCCCCEE	47.11	29967540
373	Ubiquitination	ELGFGSAKEAVTGSR HCCCCCHHHHHCCCC	48.15	29967540
406	Ubiquitination	EKSIIDCKFNAESQG CCEEEEEEEECHHCC	37.59	29967540
455	N-linked_Glycosylation	VEVLVERNGSLVWGM EEEEEEECCEEEEEE	30.79	23319596
600	Phosphorylation	YRRLLRFSSQIHNNG HHHHHHHHHHHCCCC	18.20	28348404
601	Phosphorylation	RRLLRFSSQIHNNGQ HHHHHHHHHHCCCCC	30.37	28348404
609	Phosphorylation	QIHNNGQSDFRPKNG HHCCCCCCCCCCCCC	39.86	-
644	N-linked_Glycosylation	HYDLLNLNGTKVAEG EEEEECCCCCCCCCC	55.82	23319596
689	Other	TMGCWDMYRHDIDCQ EECHHHHHCCCCCCC	11.43	29581294
689	"2',4',5'-topaquinone"	TMGCWDMYRHDIDCQ EECHHHHHCCCCCCC	11.43	-
759	Ubiquitination	FSEETEKKFEHFSGL CCHHHHHHHHHHHHH	50.15	29967540
772	Phosphorylation	GLLNNQLSPQ----- HHHHCCCCCC-----	16.10	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LOXL2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
455	N	Glycosylation	N-glycosylation on Asn-455 and Asn-644 may be essential for proper folding and secretion; may be composed of a fucosylated carbohydrates attached to a trimannose N-linked glycan core.	23319596
644	N	Glycosylation	N-glycosylation on Asn-455 and Asn-644 may be essential for proper folding and secretion; may be composed of a fucosylated carbohydrates attached to a trimannose N-linked glycan core.	23319596

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LOXL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTA1_HUMAN	MTA1	physical	22483618
MTA2_HUMAN	MTA2	physical	22483618
RBBP4_HUMAN	RBBP4	physical	22483618
RBBP7_HUMAN	RBBP7	physical	22483618
SIN3A_HUMAN	SIN3A	physical	22483618
HDAC1_HUMAN	HDAC1	physical	22483618
EZH2_HUMAN	EZH2	physical	22483618
H31_HUMAN	HIST1H3A	physical	22483618
RED_HUMAN	IK	physical	28514442
FBX7_HUMAN	FBXO7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.