dbPTM

TATD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TATD2_HUMAN
UniProt AC	Q93075
Protein Name	Putative deoxyribonuclease TATDN2
Gene Name	TATDN2
Organism	Homo sapiens (Human).
Sequence Length	761
Subcellular Localization	Nucleus .
Protein Description	Putative deoxyribonuclease..
Protein Sequence	MASERGKVKHNWSSTSEGCPRKRSCLREPCDVAPSSRPAQRSASRSGGPSSPKRLKAQKEDDVACSRRLSWGSSRRRNNSSSSFSPHFLGPGVGGAASKGCLIRNTRGFLSSGGSPLRPANASLEEMASLEEEACSLKVDSKDSSHNSTNSEFAAEAEGQNDTIEEPNKVQKRKRDRLRDQGSTMIYLKAIQGILGKSMPKRKGEAATRAKPSAAEHPSHGEGPARSEGPAKTAEGAARSVTVTAAQKEKDATPEVSMEEDKTVPERSSFYDRRVVIDPQEKPSEEPLGDRRTVIDKCSPPLEFLDDSDSHLEIQKHKDREVVMEHPSSGSDWSDVEEISTVRFSQEEPVSLKPSAVPEPSSFTTDYVMYPPHLYSSPWCDYASYWTSSPKPSSYPSTGSSSNDAAQVGKSSRSRMSDYSPNSTGSVQNTSRDMEASEEGWSQNSRSFRFSRSSEEREVKEKRTFQEEMPPRPCGGHASSSLPKSHLEPSLEEGFIDTHCHLDMLYSKLSFQGTFTKFRKIYSSSFPKEFQGCISDFCDPRTLTDCLWEELLKEDLVWGAFGCHPHFARYYSESQERNLLQALRHPKAVAFGEMGLDYSYKCTTPVPEQHKVFERQLQLAVSLKKPLVIHCREADEDLLEIMKKFVPPDYKIHRHCFTGSYPVIEPLLKYFPNMSVGFTAVLTYSSAWEAREALRQIPLERIIVETDAPYFLPRQVPKSLCQYAHPGLALHTVREIARVKDQPLSLTLAALRENTSRLYSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	GKVKHNWSSTSEGCP CCCCCCCCCCCCCCC	29.11	-
14	Phosphorylation	KVKHNWSSTSEGCPR CCCCCCCCCCCCCCC	27.80	-
15	Phosphorylation	VKHNWSSTSEGCPRK CCCCCCCCCCCCCCC	25.86	-
16	Phosphorylation	KHNWSSTSEGCPRKR CCCCCCCCCCCCCCH	33.66	-
42	Phosphorylation	SSRPAQRSASRSGGP CCCCCHHHHHHCCCC	20.65	27251275
44	Phosphorylation	RPAQRSASRSGGPSS CCCHHHHHHCCCCCC	28.38	27251275
46	Phosphorylation	AQRSASRSGGPSSPK CHHHHHHCCCCCCHH	45.68	27251275
50	Phosphorylation	ASRSGGPSSPKRLKA HHHCCCCCCHHHHHC	63.65	27251275
51	Phosphorylation	SRSGGPSSPKRLKAQ HHCCCCCCHHHHHCC	37.26	28985074
56	Methylation	PSSPKRLKAQKEDDV CCCHHHHHCCCCCCC	53.45	24129315
70	Phosphorylation	VACSRRLSWGSSRRR CHHHHHCCCCCCCCC	27.81	25159151
73	Phosphorylation	SRRLSWGSSRRRNNS HHHCCCCCCCCCCCC	17.89	30108239
74	Phosphorylation	RRLSWGSSRRRNNSS HHCCCCCCCCCCCCC	26.35	30108239
80	Phosphorylation	SSRRRNNSSSSFSPH CCCCCCCCCCCCCCC	34.84	23401153
81	Phosphorylation	SRRRNNSSSSFSPHF CCCCCCCCCCCCCCC	31.93	25159151
82	Phosphorylation	RRRNNSSSSFSPHFL CCCCCCCCCCCCCCC	34.91	28450419
83	Phosphorylation	RRNNSSSSFSPHFLG CCCCCCCCCCCCCCC	31.52	28450419
85	Phosphorylation	NNSSSSFSPHFLGPG CCCCCCCCCCCCCCC	21.29	28450419
98	Phosphorylation	PGVGGAASKGCLIRN CCCCCCHHCCCEEEC	29.10	27251275
111	Phosphorylation	RNTRGFLSSGGSPLR ECCCCCHHCCCCCCC	25.36	28387310
112	Phosphorylation	NTRGFLSSGGSPLRP CCCCCHHCCCCCCCC	49.69	28450419
115	Phosphorylation	GFLSSGGSPLRPANA CCHHCCCCCCCCCCC	25.04	22115753
123	Phosphorylation	PLRPANASLEEMASL CCCCCCCCHHHHHHC	35.80	28450419
129	Phosphorylation	ASLEEMASLEEEACS CCHHHHHHCHHHHHC	34.70	28102081
183	Phosphorylation	DRLRDQGSTMIYLKA HHHHHHCCHHHHHHH	14.79	28450419
184	Phosphorylation	RLRDQGSTMIYLKAI HHHHHCCHHHHHHHH	17.89	28450419
197	Acetylation	AIQGILGKSMPKRKG HHHHHHCCCCCCCCC	39.89	25953088
198	Phosphorylation	IQGILGKSMPKRKGE HHHHHCCCCCCCCCC	38.22	23909892
211	Ubiquitination	GEAATRAKPSAAEHP CCHHCCCCCCCCCCC	35.89	-
253	Phosphorylation	AQKEKDATPEVSMEE HHHHCCCCCCCCCCC	30.07	21815630
257	Phosphorylation	KDATPEVSMEEDKTV CCCCCCCCCCCCCCC	20.86	25159151
263	Phosphorylation	VSMEEDKTVPERSSF CCCCCCCCCCCCCCC	54.32	27251275
293	Phosphorylation	EPLGDRRTVIDKCSP CCCCCCCCCHHHCCC	23.78	30266825
299	Phosphorylation	RTVIDKCSPPLEFLD CCCHHHCCCCHHHCC	34.98	30266825
308	Phosphorylation	PLEFLDDSDSHLEIQ CHHHCCCCCCCEEEH	40.45	30266825
310	Phosphorylation	EFLDDSDSHLEIQKH HHCCCCCCCEEEHHC	33.64	30266825
328	Phosphorylation	EVVMEHPSSGSDWSD EEHHCCCCCCCCCHH	49.60	27732954
329	Phosphorylation	VVMEHPSSGSDWSDV EHHCCCCCCCCCHHC	46.93	27732954
331	Phosphorylation	MEHPSSGSDWSDVEE HCCCCCCCCCHHCCE	37.54	27732954
334	Phosphorylation	PSSGSDWSDVEEIST CCCCCCCHHCCEEEE	36.45	27732954
340	Phosphorylation	WSDVEEISTVRFSQE CHHCCEEEEEEECCC	24.91	27732954
341	Phosphorylation	SDVEEISTVRFSQEE HHCCEEEEEEECCCC	22.74	27732954
393	O-linked_Glycosylation	WTSSPKPSSYPSTGS CCCCCCCCCCCCCCC	48.94	28411811
397	Phosphorylation	PKPSSYPSTGSSSND CCCCCCCCCCCCCCC	36.85	27732954
398	Phosphorylation	KPSSYPSTGSSSNDA CCCCCCCCCCCCCCH	36.26	27732954
400	Phosphorylation	SSYPSTGSSSNDAAQ CCCCCCCCCCCCHHH	30.59	27732954
401	Phosphorylation	SYPSTGSSSNDAAQV CCCCCCCCCCCHHHH	34.21	25627689
402	Phosphorylation	YPSTGSSSNDAAQVG CCCCCCCCCCHHHHC	40.19	27732954
417	Phosphorylation	KSSRSRMSDYSPNST CCCHHCCCCCCCCCC	32.08	30108239
419	Phosphorylation	SRSRMSDYSPNSTGS CHHCCCCCCCCCCCC	20.79	30108239
420	Phosphorylation	RSRMSDYSPNSTGSV HHCCCCCCCCCCCCC	23.69	21082442
423	Phosphorylation	MSDYSPNSTGSVQNT CCCCCCCCCCCCEEC	37.21	30576142
424	Phosphorylation	SDYSPNSTGSVQNTS CCCCCCCCCCCEECC	39.87	30108239
426	Phosphorylation	YSPNSTGSVQNTSRD CCCCCCCCCEECCCC	22.18	27732954
430	Phosphorylation	STGSVQNTSRDMEAS CCCCCEECCCCCCHH	14.19	27732954
431	Phosphorylation	TGSVQNTSRDMEASE CCCCEECCCCCCHHH	33.56	30576142
437	Phosphorylation	TSRDMEASEEGWSQN CCCCCCHHHCCCCCC	23.91	24114839
442	Phosphorylation	EASEEGWSQNSRSFR CHHHCCCCCCCCCCC	30.27	24114839
445	Phosphorylation	EEGWSQNSRSFRFSR HCCCCCCCCCCCCCC	22.97	24114839
451	Phosphorylation	NSRSFRFSRSSEERE CCCCCCCCCCHHHHH	27.31	23403867
453	Phosphorylation	RSFRFSRSSEEREVK CCCCCCCCHHHHHHH	40.69	23403867
454	Phosphorylation	SFRFSRSSEEREVKE CCCCCCCHHHHHHHH	42.22	23403867
464	Phosphorylation	REVKEKRTFQEEMPP HHHHHHHCCCCCCCC	40.51	-
479	Phosphorylation	RPCGGHASSSLPKSH CCCCCCCCCCCCHHH	18.13	26699800
480	Phosphorylation	PCGGHASSSLPKSHL CCCCCCCCCCCHHHC	36.36	26699800
481	Phosphorylation	CGGHASSSLPKSHLE CCCCCCCCCCHHHCC	46.31	26699800
517	Ubiquitination	SFQGTFTKFRKIYSS HCCCCCHHHHHHHHC	38.69	-
528	Ubiquitination	IYSSSFPKEFQGCIS HHHCCCCHHHCCHHH	69.97	-
611	Ubiquitination	TPVPEQHKVFERQLQ CCCCHHHHHHHHHHH	48.60	-
625	Ubiquitination	QLAVSLKKPLVIHCR HHHHHCCCCEEEEEE	49.21	-
643	Ubiquitination	EDLLEIMKKFVPPDY HHHHHHHHHHCCCCC	49.04	-
644	Ubiquitination	DLLEIMKKFVPPDYK HHHHHHHHHCCCCCE	33.93	-
651	Ubiquitination	KFVPPDYKIHRHCFT HHCCCCCEEHHHHCC	39.14	-
718	Ubiquitination	FLPRQVPKSLCQYAH CCCCCCCHHHHHHCC	58.15	-
740	Ubiquitination	VREIARVKDQPLSLT HHHHHHCCCCCHHHH	45.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TATD2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TATD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TATD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TATD2_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TATD2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420, AND MASSSPECTROMETRY.	15302935 [Abstract]